ES2045921T3 - Dispositivos para uso en procesos de ensayos quimicos. - Google Patents

Dispositivos para uso en procesos de ensayos quimicos.

Info

Publication number
ES2045921T3
ES2045921T3 ES90908261T ES90908261T ES2045921T3 ES 2045921 T3 ES2045921 T3 ES 2045921T3 ES 90908261 T ES90908261 T ES 90908261T ES 90908261 T ES90908261 T ES 90908261T ES 2045921 T3 ES2045921 T3 ES 2045921T3
Authority
ES
Spain
Prior art keywords
cavity
devices
transports
chemical test
test processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90908261T
Other languages
English (en)
Inventor
John Worthington Attridge
Alan Martin Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARS HOLDING 89 NV
Original Assignee
ARS HOLDING 89 NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARS HOLDING 89 NV filed Critical ARS HOLDING 89 NV
Application granted granted Critical
Publication of ES2045921T3 publication Critical patent/ES2045921T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0822Slides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/168Specific optical properties, e.g. reflective coatings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0346Capillary cells; Microcells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706Reagent provision
    • G01N2021/7733Reservoir, liquid reagent
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769Measurement method of reaction-produced change in sensor
    • G01N2021/7786Fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Plasma & Fusion (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA INVENCION ESTA RELACIONADA CON UN MECANISMO QUE SE USA EN METODOS DE ANALISIS, POR EJEMPLO EN AQUELLOS RELACIONADOS CON MOIEDADES FLUORESCENTES . EL MECANISMO POSEE UNA CAVIDAD O CAVIDADES EN LAS CUALES SE PUEDE INTRODUCIR UN LIQUIDO DE MUESTRA MEDIANTE ACCION CAPILAR. CADA CAVIDAD ESTA FORMADA DE DOS PLACAS TRANSPARENTES SOLIDAS: UNA ESTA ADAPTADA PARA ACTUAR COMO GUIA DE ONDAS Y TRANSPORTA UN REAGENTE INMOVILIZADO ADECUADO EN SU SUPERFICIE DENTRO DE LA CAVIDAD; LA OTRA TRANSPORTA SOBRE SU SUPERFICIE EXTERNA Y OPCIONALMENTE TAMBIEN EN PARTE SOLO DE SU SUPERFICIE INTERNA UNA CAPA DE MATERIAL LIGERO ABSORBENTE. LA INVENCION TAMBIEN ESTA RELACIONADA CON UN METODO PARA LA FABRICACION DE MECANISMOS RELATIVOS A LA INVENCION, Y CON UN METODO PARA ANALIZAR UN LIGANDO QUE SE ENCUENTRA EN LA MUESTRA, UTILIZANDO UN MECANISMO QUE ESTE DE ACUERDO CON LA INVENCION.
ES90908261T 1989-05-18 1990-05-17 Dispositivos para uso en procesos de ensayos quimicos. Expired - Lifetime ES2045921T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898911462A GB8911462D0 (en) 1989-05-18 1989-05-18 Devices for use in chemical test procedures

Publications (1)

Publication Number Publication Date
ES2045921T3 true ES2045921T3 (es) 1994-01-16

Family

ID=10656979

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90908261T Expired - Lifetime ES2045921T3 (es) 1989-05-18 1990-05-17 Dispositivos para uso en procesos de ensayos quimicos.

Country Status (11)

Country Link
US (1) US5192502A (es)
EP (1) EP0426817B1 (es)
JP (1) JP2525958B2 (es)
AT (1) ATE96228T1 (es)
AU (1) AU617254B2 (es)
CA (1) CA2031515C (es)
DE (1) DE69004049T2 (es)
DK (1) DK0426817T3 (es)
ES (1) ES2045921T3 (es)
GB (1) GB8911462D0 (es)
WO (1) WO1990014590A1 (es)

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GB9008261D0 (en) * 1990-04-11 1990-06-13 Ares Serono Res & Dev Ltd Method of improving assay sensitivity
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GB9212302D0 (en) * 1992-06-10 1992-07-22 Applied Research Systems Method for improving measurement precision in evanescent wave optical biosensor assays
AU704947B2 (en) * 1993-05-18 1999-05-06 University Of Utah Research Foundation Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
US5919712A (en) 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
AU749504B2 (en) * 1993-05-18 2002-06-27 University Of Utah Research Foundation Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
JP3326708B2 (ja) * 1993-08-31 2002-09-24 日水製薬株式会社 光学的測定装置およびその方法
GB9325718D0 (en) * 1993-12-16 1994-02-16 Ars Holding 89 Nv Sensor device for sandwich assay
GB9404749D0 (en) * 1994-03-10 1994-04-27 Ars Holding 89 Nv Device for use in spectrophotometry
US5490972A (en) * 1994-04-29 1996-02-13 Johnson & Johnson Clinical Diagnostics, Inc. Raising mechanism for incubator cover
US5515170A (en) * 1994-09-08 1996-05-07 Lifescan, Inc. Analyte detection device having a serpentine passageway for indicator strips
US5526120A (en) * 1994-09-08 1996-06-11 Lifescan, Inc. Test strip with an asymmetrical end insuring correct insertion for measuring
US6335203B1 (en) 1994-09-08 2002-01-01 Lifescan, Inc. Optically readable strip for analyte detection having on-strip orientation index
CN1109895C (zh) * 1994-09-08 2003-05-28 生命扫描有限公司 试验片条、检测该片条的仪器及检测方法
US5563031A (en) * 1994-09-08 1996-10-08 Lifescan, Inc. Highly stable oxidative coupling dye for spectrophotometric determination of analytes
GB9419001D0 (en) 1994-09-21 1994-11-09 Applied Research Systems Assay method
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5909227A (en) * 1995-04-12 1999-06-01 Eastman Kodak Company Photograph processing and copying system using coincident force drop-on-demand ink jet printing
MX9703495A (es) * 1995-09-12 1997-07-31 Becton Dickinson Co Dispositivo y metodo para amplificacion y ensayo de adn.
US6972183B1 (en) 1997-06-16 2005-12-06 Diversa Corporation Capillary array-based enzyme screening
US6794127B1 (en) 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
GB9609653D0 (en) 1996-05-09 1996-07-10 Applied Research Ars Holding N Method of assay
WO1998028623A1 (en) * 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
US6511854B1 (en) * 1997-07-31 2003-01-28 The Uab Research Foundation Regenerable biosensor using total internal reflection fluorescence with electrochemical control
US6222619B1 (en) 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
DE19753847A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit Kapillarkanal
DE19753851A1 (de) * 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Vorrichtung zum kapillaren Flüssigkeitstransport
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US6438279B1 (en) 1999-01-07 2002-08-20 Cornell Research Foundation, Inc. Unitary microcapiliary and waveguide structure and method of fabrication
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US6395483B1 (en) 1999-09-02 2002-05-28 3M Innovative Properties Company Arrays with mask layers
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
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Also Published As

Publication number Publication date
DE69004049D1 (de) 1993-11-25
CA2031515A1 (en) 1990-11-19
GB8911462D0 (en) 1989-07-05
EP0426817B1 (en) 1993-10-20
JP2525958B2 (ja) 1996-08-21
ATE96228T1 (de) 1993-11-15
DK0426817T3 (da) 1994-02-21
JPH03506078A (ja) 1991-12-26
US5192502A (en) 1993-03-09
AU617254B2 (en) 1991-11-21
EP0426817A1 (en) 1991-05-15
DE69004049T2 (de) 1994-04-07
AU5740390A (en) 1990-12-18
CA2031515C (en) 1996-06-04
WO1990014590A1 (en) 1990-11-29

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