JP2025537239A - Ｋｒａｓ＿ｇ１２ｖ変異抗原特異的ｔｃｒ、並びに、斯かるｔｃｒ及びｃｄ８を共発現する再指向化ｃｄ４ ｔ細胞 - Google Patents

Ｋｒａｓ＿ｇ１２ｖ変異抗原特異的ｔｃｒ、並びに、斯かるｔｃｒ及びｃｄ８を共発現する再指向化ｃｄ４ ｔ細胞

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JP2025537239A
JP2025537239A JP2025526492A JP2025526492A JP2025537239A JP 2025537239 A JP2025537239 A JP 2025537239A JP 2025526492 A JP2025526492 A JP 2025526492A JP 2025526492 A JP2025526492 A JP 2025526492A JP 2025537239 A JP2025537239 A JP 2025537239A
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ソンミン ペン
ドゥオ アン
シャン ジョン
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ネオワイズ バイオテクノロジー カンパニー，リミテッド
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    • A61K40/00—Cellular immunotherapy
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C12N2510/00—Genetically modified cells
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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JP2025526492A 2022-11-04 2023-02-24 Ｋｒａｓ＿ｇ１２ｖ変異抗原特異的ｔｃｒ、並びに、斯かるｔｃｒ及びｃｄ８を共発現する再指向化ｃｄ４ ｔ細胞 Pending JP2025537239A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202211379445.6A CN115960204B (zh) 2022-11-04 2022-11-04 Kras_g12v突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞
CN202211379445.6 2022-11-04
PCT/CN2023/078124 WO2024093056A1 (zh) 2022-11-04 2023-02-24 Kras_g12v突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞

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JP2025537239A true JP2025537239A (ja) 2025-11-14
JP2025537239A5 JP2025537239A5 (https=) 2026-02-27

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EP (1) EP4613762A1 (https=)
JP (1) JP2025537239A (https=)
CN (2) CN115960204B (https=)
AU (1) AU2023371349A1 (https=)
WO (1) WO2024093056A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN118852403A (zh) * 2023-04-26 2024-10-29 北京鼎成肽源生物技术有限公司 靶向kras突变的tcr分子和细胞及其应用
CN118852452A (zh) * 2023-04-28 2024-10-29 北京鼎成肽源生物技术有限公司 靶向kras g12突变的tcr分子和细胞及其应用
CN118909132A (zh) * 2023-05-06 2024-11-08 北京鼎成肽源生物技术有限公司 靶向kras g12v突变的tcr分子和细胞及其应用
WO2025056681A1 (en) * 2023-09-15 2025-03-20 Medigene Immunotherapies Gmbh T-CELL RECEPTOR AGAINST mKRAS7-16 G12V AND G12C
CN120157754A (zh) * 2023-12-14 2025-06-17 新景智源生物科技(苏州)有限公司 Kras_g12d突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞
CN120518771A (zh) * 2024-02-20 2025-08-22 上海信谱生物医药科技有限公司 一种识别kras突变的t细胞受体及其编码序列

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Publication number Priority date Publication date Assignee Title
CR20200287A (es) * 2017-12-04 2020-11-11 Us Health Receptores de células t restringidos a antígeno leucocitario humano (hla) clase i contra sarcoma de rata (ras) mutado
CN112646024B (zh) * 2019-10-10 2023-03-24 香雪生命科学技术（广东）有限公司 一种识别kras突变的t细胞受体及其编码序列
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
CN112300269B (zh) * 2020-09-29 2022-12-09 中国科学院微生物研究所 Kras突变特异性t细胞受体筛选及抗肿瘤用途

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CN115960204A (zh) 2023-04-14
EP4613762A1 (en) 2025-09-10
WO2024093056A1 (zh) 2024-05-10
CN117430689A (zh) 2024-01-23
AU2023371349A1 (en) 2025-05-22
CN115960204B (zh) 2023-08-25

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