JP2025514437A - 二重特異性抗体及び眼疾患の処置方法 - Google Patents

二重特異性抗体及び眼疾患の処置方法 Download PDF

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JP2025514437A
JP2025514437A JP2024564498A JP2024564498A JP2025514437A JP 2025514437 A JP2025514437 A JP 2025514437A JP 2024564498 A JP2024564498 A JP 2024564498A JP 2024564498 A JP2024564498 A JP 2024564498A JP 2025514437 A JP2025514437 A JP 2025514437A
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seq
amino acid
acid sequence
cfhr4
bispecific antibody
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Japanese (ja)
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JP2025514437A5 (enExample
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アンドリュー ピーターソン
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ブロードウィング バイオ リミテッド ライアビリティ カンパニー
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Publication of JP2025514437A publication Critical patent/JP2025514437A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2024564498A 2022-04-29 2023-04-28 二重特異性抗体及び眼疾患の処置方法 Pending JP2025514437A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263336766P 2022-04-29 2022-04-29
US63/336,766 2022-04-29
PCT/US2023/020365 WO2023212298A1 (en) 2022-04-29 2023-04-28 Bispecific antibodies and methods of treating ocular disease

Publications (2)

Publication Number Publication Date
JP2025514437A true JP2025514437A (ja) 2025-05-02
JP2025514437A5 JP2025514437A5 (enExample) 2026-05-12

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JP2024564498A Pending JP2025514437A (ja) 2022-04-29 2023-04-28 二重特異性抗体及び眼疾患の処置方法

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US (1) US20250346653A1 (enExample)
EP (1) EP4514845A1 (enExample)
JP (1) JP2025514437A (enExample)
KR (1) KR20250018169A (enExample)
CN (1) CN119487063A (enExample)
AU (1) AU2023260823A1 (enExample)
CL (1) CL2024003285A1 (enExample)
IL (1) IL316615A (enExample)
MX (1) MX2024013187A (enExample)
WO (1) WO2023212298A1 (enExample)

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US12121587B1 (en) 2023-12-26 2024-10-22 Medicovestor, Inc. Dimeric antibodies
US12600795B2 (en) 2023-12-26 2026-04-14 Medicovestor, Inc. Oligomeric IgG for immunotherapeutics and diagnostics
US12378314B1 (en) * 2024-02-02 2025-08-05 Medicovestor, Inc. Proteins that bind folate receptor alpha including fully-human antibodies

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EP4514845A1 (en) 2025-03-05
IL316615A (en) 2024-12-01
US20250346653A1 (en) 2025-11-13
WO2023212298A1 (en) 2023-11-02
CN119487063A (zh) 2025-02-18
CL2024003285A1 (es) 2025-04-04
KR20250018169A (ko) 2025-02-04
AU2023260823A1 (en) 2024-11-14
MX2024013187A (es) 2025-02-10

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