JP2025513521A5 - - Google Patents

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Publication number
JP2025513521A5
JP2025513521A5 JP2024562265A JP2024562265A JP2025513521A5 JP 2025513521 A5 JP2025513521 A5 JP 2025513521A5 JP 2024562265 A JP2024562265 A JP 2024562265A JP 2024562265 A JP2024562265 A JP 2024562265A JP 2025513521 A5 JP2025513521 A5 JP 2025513521A5
Authority
JP
Japan
Prior art keywords
formula
fmoc
following
obtaining
carried out
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024562265A
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English (en)
Japanese (ja)
Other versions
JP2025513521A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2023/019452 external-priority patent/WO2023205451A1/en
Publication of JP2025513521A publication Critical patent/JP2025513521A/ja
Publication of JP2025513521A5 publication Critical patent/JP2025513521A5/ja
Pending legal-status Critical Current

Links

JP2024562265A 2022-04-22 2023-04-21 治療薬を送達するための環状ペプチド Pending JP2025513521A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202263363450P 2022-04-22 2022-04-22
US63/363,450 2022-04-22
US202263354471P 2022-06-22 2022-06-22
US63/354,471 2022-06-22
US202263377754P 2022-09-30 2022-09-30
US63/377,754 2022-09-30
PCT/US2023/019452 WO2023205451A1 (en) 2022-04-22 2023-04-21 Cyclic peptides for delivering therapeutics

Publications (2)

Publication Number Publication Date
JP2025513521A JP2025513521A (ja) 2025-04-24
JP2025513521A5 true JP2025513521A5 (https=) 2026-04-28

Family

ID=86332269

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024562265A Pending JP2025513521A (ja) 2022-04-22 2023-04-21 治療薬を送達するための環状ペプチド

Country Status (6)

Country Link
US (1) US20250289851A1 (https=)
EP (1) EP4511385A1 (https=)
JP (1) JP2025513521A (https=)
CN (1) CN119156395A (https=)
CA (1) CA3249036A1 (https=)
WO (1) WO2023205451A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL326646A (en) 2023-08-17 2026-04-01 Entrada Therapeutics Inc Intracellular targeting of oligonucleotides
WO2025038901A1 (en) 2023-08-17 2025-02-20 Entrada Therapeutics, Inc. Cyclic peptides for delivering therapeutics

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5521063A (en) 1985-03-15 1996-05-28 Antivirals Inc. Polynucleotide reagent containing chiral subunits and methods of use
US5217866A (en) 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
JP2004537517A (ja) 2001-05-17 2004-12-16 エイブイアイ バイオファーマ， インコーポレイテッド ｃ−ｍｙｃアンチセンスオリゴマーを使用した、癌を処置するための併用アプローチ
AU2002342057B2 (en) 2001-10-16 2009-01-22 Avi Biopharma, Inc. Antisense antiviral agent and method for treating ssRNA viral infection
EP1713332A4 (en) 2004-01-23 2010-08-18 Avi Biopharma Inc ANTISENSE OLIGOMERS AND METHOD FOR INDUCTION OF IMMUNOTHERAPY AND IMMUNOSUPPRESSION
US7402574B2 (en) 2004-03-12 2008-07-22 Avi Biopharma, Inc. Antisense composition and method for treating cancer
US8357664B2 (en) 2004-10-26 2013-01-22 Avi Biopharma, Inc. Antisense antiviral compound and method for treating influenza viral infection
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
US8329668B2 (en) 2005-09-08 2012-12-11 Avi Biopharma, Inc. Antisense antiviral compound and method for treating picornavirus infection
DK2735568T3 (da) 2006-05-10 2017-11-13 Sarepta Therapeutics Inc Oligonukleotidanaloger med kationiske bindinger mellem underenheder
EP3443976A1 (en) 2007-06-29 2019-02-20 Sarepta Therapeutics, Inc. Tissue specific peptide conjugates and methods
US20100016215A1 (en) 2007-06-29 2010-01-21 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
US8299206B2 (en) 2007-11-15 2012-10-30 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
US8076476B2 (en) 2007-11-15 2011-12-13 Avi Biopharma, Inc. Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
CN112574988A (zh) 2008-10-24 2021-03-30 萨雷普塔治疗公司 用于dmd的多外显子跳跃组合物
US20100210989A1 (en) 2008-12-23 2010-08-19 Janet Lesley Macpherson Processing blood
RS55610B1 (sr) 2010-09-30 2017-06-30 Nippon Shinyaku Co Ltd Derivat morfolino nukleinske kiseline
US9161948B2 (en) 2011-05-05 2015-10-20 Sarepta Therapeutics, Inc. Peptide oligonucleotide conjugates
ES2727481T3 (es) 2011-11-30 2019-10-16 Sarepta Therapeutics Inc Inclusión inducida de exón en atrofia muscular espinal
WO2014189142A1 (ja) 2013-05-24 2014-11-27 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
EP3613426A1 (en) * 2014-05-21 2020-02-26 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
TW202500573A (zh) * 2016-11-22 2025-01-01 俄亥俄州立創新基金會 細胞穿透肽序列
EA201991450A1 (ru) 2017-09-22 2019-12-30 Сарепта Терапьютикс, Инк. Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии
EP3672601B1 (en) 2017-09-25 2023-09-13 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers via fast-flow synthesis
TW201945014A (zh) * 2018-02-22 2019-12-01 美商安卓達治療股份有限公司 用於治療粒線體性神經胃腸腦病變之組合物及方法
US10758629B2 (en) 2018-05-29 2020-09-01 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
US12012427B2 (en) 2019-10-31 2024-06-18 Indian Association For The Cultivation Of Science Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer
CN117120456A (zh) 2020-12-11 2023-11-24 卫材R&D管理有限公司 聚-吗啉代寡核苷酸缺口体
US20240358845A1 (en) * 2021-05-10 2024-10-31 Entrada Therapeutics, Inc. Compositions and methods for intracellular therapeutics
WO2023081893A1 (en) * 2021-11-08 2023-05-11 Entrada Therapeutics, Inc. Intracellular targeting of oligonucleotides

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