JP2025507472A - ケトアミド系誘導体及びその製薬における使用 - Google Patents

ケトアミド系誘導体及びその製薬における使用 Download PDF

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JP2025507472A
JP2025507472A JP2023580943A JP2023580943A JP2025507472A JP 2025507472 A JP2025507472 A JP 2025507472A JP 2023580943 A JP2023580943 A JP 2023580943A JP 2023580943 A JP2023580943 A JP 2023580943A JP 2025507472 A JP2025507472 A JP 2025507472A
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pharma
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acceptable salt
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JP2025507472A5 (https=
JPWO2023165334A5 (https=
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ションヨン ヤン
リンリー リー
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Westvac Biopharma Co Ltd
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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JPH09500087A (ja) * 1992-06-24 1997-01-07 コーテックス ファーマシューティカルズ インコーポレイテッド カルパイン活性の増大に関連した健康障害の抑制及び処置におけるカルパイン阻害剤の使用法
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US6303579B1 (en) * 1996-10-31 2001-10-16 Alcon Laboratories, Inc. Use of calpain inhibitors to treat ocular neural pathology
CN1306526A (zh) * 1998-04-20 2001-08-01 Basf公司 具有半胱氨酸蛋白酶抑制作用的新的杂环取代酰胺
AU2002232558A1 (en) * 2000-12-12 2002-06-24 Corvas International, Inc. Compounds, compositions and methods for treatment of parasitic infections
JP2006503069A (ja) * 2002-09-25 2006-01-26 ジョージア テック リサーチ コーポレイション 慢性神経疾患におけるケトアミド阻害剤
US8236798B2 (en) * 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
US8598211B2 (en) * 2009-12-22 2013-12-03 Abbvie Inc. Carboxamide compounds and their use as calpain inhibitors IV
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BR112019006110A2 (pt) * 2016-09-28 2019-09-10 Blade Therapeutics Inc moduladores de calpaína e usos terapêuticos dos mesmos
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CN114057702B (zh) * 2020-07-31 2022-09-30 四川大学 一种新型冠状病毒主蛋白酶的抑制剂及其制备方法和用途
US20240083885A1 (en) * 2020-12-04 2024-03-14 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for inhibiting m pro protease activity and for preventing and treating sars-cov-2 infection
WO2022265577A2 (en) * 2021-06-15 2022-12-22 Agency For Science, Technology And Research Coronavirus enzyme modulators, methods of synthesis and uses thereof
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