JP2025503448A5 - - Google Patents

Info

Publication number
JP2025503448A5
JP2025503448A5 JP2024536125A JP2024536125A JP2025503448A5 JP 2025503448 A5 JP2025503448 A5 JP 2025503448A5 JP 2024536125 A JP2024536125 A JP 2024536125A JP 2024536125 A JP2024536125 A JP 2024536125A JP 2025503448 A5 JP2025503448 A5 JP 2025503448A5
Authority
JP
Japan
Prior art keywords
pharmaceutically acceptable
compound according
acceptable form
isotopic derivative
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024536125A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025503448A (ja
Filing date
Publication date
Priority claimed from PCT/CN2021/138744 external-priority patent/WO2023108536A1/en
Application filed filed Critical
Priority claimed from PCT/CN2022/139649 external-priority patent/WO2023109954A1/en
Publication of JP2025503448A publication Critical patent/JP2025503448A/ja
Publication of JP2025503448A5 publication Critical patent/JP2025503448A5/ja
Pending legal-status Critical Current

Links

JP2024536125A 2021-12-16 2022-12-16 Tyk2阻害剤および組成物ならびにその方法 Pending JP2025503448A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/138744 2021-12-16
PCT/CN2021/138744 WO2023108536A1 (en) 2021-12-16 2021-12-16 Tyk2 inhibitors and compositions and methods thereof
PCT/CN2022/106876 WO2023109120A1 (en) 2021-12-16 2022-07-20 Tyk2 inhibitors and compositions and methods thereof
CNPCT/CN2022/106876 2022-07-20
PCT/CN2022/139649 WO2023109954A1 (en) 2021-12-16 2022-12-16 Tyk2 inhibitors and compositions and methods thereof

Publications (2)

Publication Number Publication Date
JP2025503448A JP2025503448A (ja) 2025-02-04
JP2025503448A5 true JP2025503448A5 (enExample) 2025-12-19

Family

ID=86774877

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024536125A Pending JP2025503448A (ja) 2021-12-16 2022-12-16 Tyk2阻害剤および組成物ならびにその方法

Country Status (10)

Country Link
US (2) US12129250B2 (enExample)
EP (1) EP4448514A4 (enExample)
JP (1) JP2025503448A (enExample)
KR (1) KR20240120732A (enExample)
CN (1) CN118401516A (enExample)
AU (1) AU2022412835A1 (enExample)
CA (1) CA3240888A1 (enExample)
IL (1) IL313571A (enExample)
TW (1) TW202339749A (enExample)
WO (1) WO2023109954A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024125651A1 (zh) * 2022-12-16 2024-06-20 津药生物科技(天津)有限公司 新型含杂环取代的丙烯酸衍生物及其用途
CN120693328A (zh) * 2023-02-07 2025-09-23 浙江华海药业股份有限公司 一种哒嗪类化合物、其制备方法和用途
WO2024254832A1 (en) * 2023-06-15 2024-12-19 Lynk Pharmaceuticals Co. Ltd. Tyk2 inhibitors and compositions and methods thereof
WO2026026866A1 (zh) * 2024-08-02 2026-02-05 北京普祺医药科技股份有限公司 作为tyk2抑制剂的大环化合物及其药物组合物
CN120607493B (zh) * 2025-06-04 2026-04-24 江西科技师范大学 一种含嘧啶结构的酰胺类化合物及其在制备tyk2 jh2激酶抑制剂中的应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
EP1883302A4 (en) * 2005-05-03 2009-05-20 Rigel Pharmaceuticals Inc JAK KINASE HEMMER AND ITS USE
WO2008009458A1 (en) 2006-07-21 2008-01-24 Novartis Ag 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors
SG165655A1 (en) 2008-04-16 2010-11-29 Portola Pharm Inc 2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors
HRP20161310T1 (hr) 2008-04-16 2016-12-02 Portola Pharmaceuticals, Inc. 2,6-diamino-pirimidin-5-il-karboksamidi kao inhibitori syk ili jak kinaza
US9139534B2 (en) 2011-04-22 2015-09-22 Signal Pharmaceuticals, Llc Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
CN104159891B (zh) 2012-01-10 2016-09-07 霍夫曼-拉罗奇有限公司 哒嗪酰胺化合物和它们作为syk 抑制剂的用途
UY34807A (es) 2012-05-16 2013-12-31 Novartis Ag Derivados monocíclicos de heteroarilcicloalquil- diamina
US9040530B2 (en) 2012-06-22 2015-05-26 Portola Pharmaceuticals, Inc. 1,2,4-triazine-6-carboxamide kinase inhibitors
LT3495358T (lt) 2012-11-08 2022-05-25 Bristol-Myers Squibb Company Amidais pakeisti heterocikliniai junginiai, naudingi kaip il-12, il-23 ir (arba) ifn alfa atsako moduliatoriai
KR102233252B1 (ko) 2012-11-08 2021-03-26 브리스톨-마이어스 스큅 컴퍼니 IL-12, IL-23 및/또는 IFNα 반응의 조절제로서 유용한 알킬-아미드-치환된 피리딜 화합물
JP2014198693A (ja) 2013-03-29 2014-10-23 大鵬薬品工業株式会社 免疫疾患の予防及び/又は治療剤
TWI582077B (zh) 2013-11-07 2017-05-11 必治妥美雅史谷比公司 作爲IL-12、IL-23及/或IFNα反應調節劑之經烷基-醯胺取代之吡啶化合物
GB201717260D0 (en) 2017-10-20 2017-12-06 Galapagos Nv Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders
EA202091269A1 (ru) 2017-11-21 2020-08-07 Бристол-Маерс Сквибб Компани Сульфон-, пиридин-, алкил-, амид-замещенные гетероарильные соединения
CN111936486B (zh) * 2018-03-22 2023-09-22 百时美施贵宝公司 用作IL-12、IL-23和/或IFNα响应的调节剂的包含吡啶的杂环化合物
JP7631193B2 (ja) * 2018-10-22 2025-02-18 アルミス インコーポレイテッド Tyk2阻害剤およびその使用
AU2019373203B2 (en) 2018-10-30 2024-10-24 Bristol-Myers Squibb Company Amide-substituted heterocyclic compounds for the treatment of conditions related to the modulation of IL-12, IL-23 and/or IFN-alpha
CN115448910B (zh) * 2019-01-28 2024-04-19 江苏豪森药业集团有限公司 一种哒嗪类衍生物抑制剂、其制备方法和应用
CN111484480B (zh) * 2019-01-29 2023-08-11 上海翰森生物医药科技有限公司 一种多环类衍生物抑制剂、其制备方法和应用
US20230093099A1 (en) * 2019-04-02 2023-03-23 Cullgen (Shanghai), Inc. Compounds and methods of treating cancers
CN114787154A (zh) * 2020-01-19 2022-07-22 苏州科睿思制药有限公司 一种Deucravacitinib的晶型及其制备方法和用途
SMT202400185T1 (it) * 2020-03-11 2024-07-09 Beijing Innocare Pharma Tech Co Ltd Composti eterociclici per inibire attività di tyk2
WO2021202652A1 (en) * 2020-04-01 2021-10-07 Eternity Bioscience Inc. Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof
AU2021254764A1 (en) * 2020-04-14 2022-11-03 Gossamer Bio Services, Inc. Substituted pyridines for the treatment of inflammatory diseases
CN113563309B (zh) * 2020-04-28 2024-12-13 浙江海正药业股份有限公司 吡啶类衍生物及其制备方法和用途
US20220002267A1 (en) 2020-06-24 2022-01-06 Eternity Bioscience Inc. Tyrosine kinase 2 inhibitors, preparation methods and medicinal uses thereof
CN113968846A (zh) 2020-07-24 2022-01-25 上海翰森生物医药科技有限公司 一种哒嗪类衍生物的盐、晶型及其制备方法和应用
WO2022117016A1 (zh) * 2020-12-02 2022-06-09 深圳微芯生物科技股份有限公司 羟肟酸酯化合物、其制备方法及其应用
CN115197196B (zh) * 2021-04-06 2024-06-18 扬子江药业集团有限公司 Tyk2抑制剂及其用途
TWI804266B (zh) * 2021-04-07 2023-06-01 大陸商上海齊魯製藥研究中心有限公司 Tyk2抑制劑及其用途
US12509360B2 (en) 2021-04-16 2025-12-30 Sri Lanka Institute Of Information Technology Method of making silver-iron titanate nanoparticles and uses thereof
CN115466257A (zh) * 2021-06-11 2022-12-13 爱科诺生物医药(香港)有限公司 具有tyk2抑制活性的化合物,包含其的药物组合物,及其应用

Similar Documents

Publication Publication Date Title
JP2025503448A5 (enExample)
JP2022510925A5 (enExample)
JP2022505525A5 (enExample)
JP2021523221A5 (enExample)
CN115697993A (zh) 作为axl抑制剂的嘧啶类化合物
JP2011509309A5 (enExample)
JP2020528889A5 (enExample)
JP2022550640A5 (enExample)
CN114430739A (zh) Egfr抑制剂、组合物及其制备方法
JP2020537657A5 (enExample)
HRP20230909T1 (hr) Spojevi inhibitori rip1 i postupci za njihovo dobivanje i upotrebu
JP2019510787A5 (enExample)
JP2021523225A5 (enExample)
JP2016520131A5 (enExample)
JP2021514001A5 (enExample)
JP2020510091A5 (enExample)
EP3013815B1 (en) Carbazole carboxamide compounds useful as kinase inhibitors
RU2003105805A (ru) Производные 4-фенилпиридина в качестве антагонистов рецепторов нейрокинина-1
RU2008141368A (ru) Новые гетероциклические соединения замещенного пиридина с антагонистической активностью схсr3
JP2014503574A5 (enExample)
JP2019531279A5 (enExample)
CA2418868A1 (en) 4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
JP2022553376A5 (enExample)
JP2021502387A5 (enExample)
JP2024529527A5 (enExample)