JP2025185070A5 - - Google Patents
Info
- Publication number
- JP2025185070A5 JP2025185070A5 JP2025166543A JP2025166543A JP2025185070A5 JP 2025185070 A5 JP2025185070 A5 JP 2025185070A5 JP 2025166543 A JP2025166543 A JP 2025166543A JP 2025166543 A JP2025166543 A JP 2025166543A JP 2025185070 A5 JP2025185070 A5 JP 2025185070A5
- Authority
- JP
- Japan
- Prior art keywords
- rnai agent
- nucleotides
- composition
- sense strand
- cytidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529132P | 2017-07-06 | 2017-07-06 | |
| US62/529,132 | 2017-07-06 | ||
| US201862631683P | 2018-02-17 | 2018-02-17 | |
| US62/631,683 | 2018-02-17 | ||
| US201862679549P | 2018-06-01 | 2018-06-01 | |
| US62/679,549 | 2018-06-01 | ||
| JP2019572571A JP2020526192A (ja) | 2017-07-06 | 2018-07-05 | アルファ−ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
| PCT/US2018/040874 WO2019010274A1 (en) | 2017-07-06 | 2018-07-05 | RNAI AGENTS OF INHIBITION OF ALPHA-ENAC GENE EXPRESSION AND METHODS OF USE |
| JP2023146393A JP2023158192A (ja) | 2017-07-06 | 2023-09-08 | アルファ－ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023146393A Division JP2023158192A (ja) | 2017-07-06 | 2023-09-08 | アルファ－ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025185070A JP2025185070A (ja) | 2025-12-18 |
| JP2025185070A5 true JP2025185070A5 (https=) | 2026-01-30 |
Family
ID=64904123
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019572571A Withdrawn JP2020526192A (ja) | 2017-07-06 | 2018-07-05 | アルファ−ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
| JP2023146393A Pending JP2023158192A (ja) | 2017-07-06 | 2023-09-08 | アルファ－ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
| JP2025166543A Pending JP2025185070A (ja) | 2017-07-06 | 2025-10-02 | アルファ－ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019572571A Withdrawn JP2020526192A (ja) | 2017-07-06 | 2018-07-05 | アルファ−ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
| JP2023146393A Pending JP2023158192A (ja) | 2017-07-06 | 2023-09-08 | アルファ－ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10590416B2 (https=) |
| EP (1) | EP3649240A4 (https=) |
| JP (3) | JP2020526192A (https=) |
| KR (1) | KR20200024793A (https=) |
| CN (2) | CN110832077B (https=) |
| AU (1) | AU2018297262A1 (https=) |
| BR (1) | BR112019023650A2 (https=) |
| CA (1) | CA3061752A1 (https=) |
| CL (1) | CL2020000019A1 (https=) |
| CO (1) | CO2019014671A2 (https=) |
| CR (1) | CR20190572A (https=) |
| EC (1) | ECSP20000655A (https=) |
| IL (1) | IL271843A (https=) |
| JO (1) | JOP20190263A1 (https=) |
| MX (1) | MX2019014800A (https=) |
| PE (1) | PE20200746A1 (https=) |
| PH (1) | PH12019502660A1 (https=) |
| TN (1) | TN2019000308A1 (https=) |
| TW (1) | TW201919654A (https=) |
| UY (1) | UY37800A (https=) |
| WO (1) | WO2019010274A1 (https=) |
| ZA (1) | ZA202100643B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TN2019000308A1 (en) * | 2017-07-06 | 2021-05-07 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE |
| US12065458B2 (en) | 2018-02-17 | 2024-08-20 | Arrowhead Pharmaceuticals, Inc. | Trialkyne linking agents and methods of use |
| JP7420727B2 (ja) * | 2018-02-17 | 2024-01-23 | アローヘッド ファーマシューティカルズ インコーポレイテッド | トリアルキン結合剤及び使用方法 |
| TW202130809A (zh) * | 2019-10-29 | 2021-08-16 | 美商愛羅海德製藥公司 | 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法 |
| CA3189065A1 (en) * | 2020-09-11 | 2022-03-17 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of dux4, compositions thereof, and methods of use |
| KR20240117104A (ko) | 2021-12-21 | 2024-07-31 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 핵산을 포함하는 조성물 및 접합체, 이들의 제조 방법 및 용도 |
| CN120615125A (zh) * | 2022-07-27 | 2025-09-09 | e-生物有限公司 | 核酸化合物 |
| AU2023313030A1 (en) * | 2022-07-27 | 2025-01-09 | E-Therapeutics Plc | Nucleic acid compounds |
| WO2024188174A1 (zh) | 2023-03-10 | 2024-09-19 | 苏州瑞博生物技术股份有限公司 | 一种药物组合物及其用途 |
| TW202503060A (zh) * | 2023-06-13 | 2025-01-16 | 大陸商上海拓界生物醫藥科技有限公司 | 靶向ＭＭＰ７的ｓｉＲＮＡ、ｓｉＲＮＡ綴合物及其醫藥用途 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4534899A (en) | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4426330A (en) | 1981-07-20 | 1984-01-17 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| GB8824593D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5356633A (en) | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5665710A (en) | 1990-04-30 | 1997-09-09 | Georgetown University | Method of making liposomal oligodeoxynucleotide compositions |
| JP3220180B2 (ja) | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
| JP3351476B2 (ja) | 1993-01-22 | 2002-11-25 | 三菱化学株式会社 | リン脂質誘導体及びそれを含有するリポソーム |
| KR100283601B1 (ko) | 1993-02-19 | 2001-03-02 | 아만 히데아키 | 글리세롤 유도체, 디바이스 및 의약 조성물 |
| US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| US5540935A (en) | 1993-12-06 | 1996-07-30 | Nof Corporation | Reactive vesicle and functional substance-fixed vesicle |
| US5543152A (en) | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5756122A (en) | 1995-06-07 | 1998-05-26 | Georgetown University | Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells |
| CA2227989A1 (en) | 1995-08-01 | 1997-02-13 | Karen Ophelia Hamilton | Liposomal oligonucleotide compositions |
| US5858397A (en) | 1995-10-11 | 1999-01-12 | University Of British Columbia | Liposomal formulations of mitoxantrone |
| US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| US5994316A (en) | 1996-02-21 | 1999-11-30 | The Immune Response Corporation | Method of preparing polynucleotide-carrier complexes for delivery to cells |
| US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
| CA2283293A1 (en) | 1997-03-11 | 1998-09-17 | Yale University | Method to diagnose and treat pathological conditions resulting from deficient ion transport such as pseudohypoaldosteronism type-1 |
| CA2294988C (en) | 1997-07-01 | 2015-11-24 | Isis Pharmaceuticals Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
| US5976849A (en) | 1998-02-05 | 1999-11-02 | Zeneca Limited | Human E3 ubiquitin protein ligase |
| DE60040274D1 (de) | 1999-03-10 | 2008-10-30 | Phogen Ltd | Verabreichung von nukleinsäuren und proteinen an zellen |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| WO2002092854A2 (en) | 2001-05-16 | 2002-11-21 | Novartis Ag | Genes expressed in breast cancer as prognostic and therapeutic targets |
| EP1478655A4 (en) | 2001-12-31 | 2006-05-10 | Algos Therapeutics Inc | METHODS AND SUBSTANCES FOR ENAC-BETA MODULATION |
| AU2003261231A1 (en) | 2002-07-26 | 2004-02-16 | Chiron Corporation | Modified small interfering rna molecules and methods of use |
| JP2004121218A (ja) | 2002-08-06 | 2004-04-22 | Jenokkusu Soyaku Kenkyusho:Kk | 気管支喘息または慢性閉塞性肺疾患の検査方法 |
| AU2003295600A1 (en) | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| AU2003293124A1 (en) | 2002-11-27 | 2004-06-23 | Artesian Therapeutics, Inc. | Heart failure gene determination and therapeutic screening |
| DE10305213A1 (de) | 2003-02-07 | 2004-08-26 | Florian Prof. Dr.med. Lang | Verwendung eines neuen Polymorphismus im hsgk1-Gen zur Diagnose der Hypertonie und Verwendung der sgk-Genfamilie zur Diagnose und Therapie des Long-Q/T-Syndroms |
| AU2004227358B8 (en) | 2003-03-31 | 2009-12-10 | Targeted Genetics Corporation | Compounds and methods to enhance rAAV transduction |
| US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
| WO2004094636A1 (en) | 2003-04-24 | 2004-11-04 | Galapagos Genomics N.V. | Effective sirna knock-down constructs |
| US20050256071A1 (en) | 2003-07-15 | 2005-11-17 | California Institute Of Technology | Inhibitor nucleic acids |
| WO2005116204A1 (ja) | 2004-05-11 | 2005-12-08 | Rnai Co., Ltd. | Ｒｎａ干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法 |
| US20060166234A1 (en) | 2004-11-22 | 2006-07-27 | Barbara Robertson | Apparatus and system having dry control gene silencing compositions |
| EP1824872B1 (en) | 2004-12-14 | 2012-02-08 | Alnylam Pharmaceuticals Inc. | Rnai modulation of mll-af4 and uses thereof |
| CN101346393B (zh) | 2005-11-02 | 2015-07-22 | 普洛体维生物治疗公司 | 修饰的siRNA分子及其应用 |
| CN101500548A (zh) | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
| JP2010505897A (ja) | 2006-10-11 | 2010-02-25 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | インフルエンザターゲット |
| AR066984A1 (es) | 2007-06-15 | 2009-09-23 | Novartis Ag | Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia) |
| KR20110095391A (ko) | 2008-11-26 | 2011-08-24 | 머크 샤프 앤드 돔 코포레이션 | 짧은 간섭 핵산 (ｓｉＮＡ)을 사용한 상피 나트륨 채널 (ＥＮａＣ) 유전자 발현의 ＲＮＡ 간섭 매개 억제 |
| US20130023578A1 (en) * | 2009-12-31 | 2013-01-24 | Samyang Biopharmaceuticals Corporation | siRNA for inhibition of c-Met expression and anticancer composition containing the same |
| SI2539451T1 (sl) | 2010-02-24 | 2016-04-29 | Arrowhead Research Corporation | Sestavki za ciljano dostavo sirna |
| US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| WO2013032829A1 (en) | 2011-08-26 | 2013-03-07 | Arrowhead Research Corporation | Poly(vinyl ester) polymers for in vivo nucleic acid delivery |
| CA2842041A1 (en) | 2012-04-18 | 2013-10-24 | Arrowhead Research Corporation | Poly(acrylate) polymers for in vivo nucleic acid delivery |
| EP3017046B1 (en) * | 2013-07-02 | 2019-09-11 | Indian Council of Medical Research | Rnai agent for inhibition of chikungunya virus |
| JOP20160211B1 (ar) * | 2015-10-01 | 2021-08-17 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| SI3535397T1 (sl) | 2016-11-01 | 2022-04-29 | Arrowhead Pharmaceuticals, Inc. | Ligandi alfa-V beta-6 integrina in njihove uporabe |
| TN2019000308A1 (en) * | 2017-07-06 | 2021-05-07 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE |
| WO2019089765A1 (en) * | 2017-11-01 | 2019-05-09 | Arrowhead Pharmcaceuticals, Inc. | Integrin ligands and uses thereof |
| JP7420727B2 (ja) * | 2018-02-17 | 2024-01-23 | アローヘッド ファーマシューティカルズ インコーポレイテッド | トリアルキン結合剤及び使用方法 |
-
2018
- 2018-07-05 TN TNP/2019/000308A patent/TN2019000308A1/en unknown
- 2018-07-05 BR BR112019023650-3A patent/BR112019023650A2/pt not_active Application Discontinuation
- 2018-07-05 EP EP18828259.4A patent/EP3649240A4/en active Pending
- 2018-07-05 WO PCT/US2018/040874 patent/WO2019010274A1/en not_active Ceased
- 2018-07-05 CA CA3061752A patent/CA3061752A1/en active Pending
- 2018-07-05 CR CR20190572A patent/CR20190572A/es unknown
- 2018-07-05 CN CN201880045293.1A patent/CN110832077B/zh active Active
- 2018-07-05 US US16/028,006 patent/US10590416B2/en active Active
- 2018-07-05 MX MX2019014800A patent/MX2019014800A/es unknown
- 2018-07-05 AU AU2018297262A patent/AU2018297262A1/en not_active Abandoned
- 2018-07-05 CN CN202411877733.3A patent/CN119662650A/zh active Pending
- 2018-07-05 KR KR1020197038728A patent/KR20200024793A/ko not_active Ceased
- 2018-07-05 JP JP2019572571A patent/JP2020526192A/ja not_active Withdrawn
- 2018-07-05 PE PE2019002542A patent/PE20200746A1/es unknown
- 2018-07-06 TW TW107123550A patent/TW201919654A/zh unknown
- 2018-07-06 UY UY0001037800A patent/UY37800A/es not_active Application Discontinuation
-
2019
- 2019-01-06 JO JOP/2019/0263A patent/JOP20190263A1/ar unknown
- 2019-11-25 PH PH12019502660A patent/PH12019502660A1/en unknown
- 2019-12-24 CO CONC2019/0014671A patent/CO2019014671A2/es unknown
-
2020
- 2020-01-03 CL CL2020000019A patent/CL2020000019A1/es unknown
- 2020-01-06 IL IL271843A patent/IL271843A/en unknown
- 2020-01-06 EC ECSENADI2020655A patent/ECSP20000655A/es unknown
- 2020-01-31 US US16/778,582 patent/US11214802B2/en active Active
-
2021
- 2021-01-29 ZA ZA2021/00643A patent/ZA202100643B/en unknown
- 2021-11-29 US US17/536,754 patent/US20220090077A1/en not_active Abandoned
-
2023
- 2023-09-08 JP JP2023146393A patent/JP2023158192A/ja active Pending
-
2025
- 2025-10-02 JP JP2025166543A patent/JP2025185070A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2025185070A5 (https=) | ||
| JP2020526192A5 (https=) | ||
| JP2024516096A5 (https=) | ||
| JP2024539193A5 (https=) | ||
| Neary et al. | Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol | |
| CN110846316B (zh) | 在基因沉默中具有降低的脱靶效应的una寡聚物 | |
| EP2230304B1 (en) | RNAI modulation of RSV and therapeutic uses thereof | |
| JP2020533334A5 (https=) | ||
| CN102099474B (zh) | 用于治疗炎症和赘生性细胞增殖的寡核苷酸 | |
| TW202208625A (zh) | 經修飾之短干擾核酸(siNA)分子及其用途 | |
| JP2023519246A5 (https=) | ||
| CN108136206A (zh) | 抗乙型肝炎病毒的组合物和药剂及其用途 | |
| CN110832077B (zh) | 用于抑制α-ENaC表达的RNAi剂及使用方法 | |
| JP2008510019A5 (https=) | ||
| EP0946201A1 (en) | Agent and method of treatment for diseases and conditions associated with respiratory ailments and lung inflammation | |
| WO1998023294A9 (en) | Agent and method of treatment for diseases and conditions associated with respiratory ailments and lung inflammation | |
| JP2023536999A (ja) | Ｂ型肝炎患者のオリゴヌクレオチド処置 | |
| ES2301659T3 (es) | Metodos para aumentar la eficacia in vivo de oligonucleotidos e inhibir la inflamacion en mamiferos. | |
| WO2010048590A1 (en) | Methods and compositions for prevention or treatment of rsv infection using modified duplex rna molecules | |
| JP2024544532A (ja) | Ｈｂｖの処置のための医薬組合せ | |
| JP2004532900A5 (https=) | ||
| JP2008516991A5 (https=) | ||
| JP2024520522A5 (https=) | ||
| JP2015532100A (ja) | アンフィレギュリンに特異的な二重鎖オリゴｒｎａ、そのような二重鎖オリゴｒｎａを含む二重鎖オリゴｒｎａの構造体及びこれを含む呼吸器疾患の予防または治療用の組成物 | |
| JP2025513757A5 (https=) |