JP2025072470A5 - - Google Patents

Info

Publication number
JP2025072470A5
JP2025072470A5 JP2025016020A JP2025016020A JP2025072470A5 JP 2025072470 A5 JP2025072470 A5 JP 2025072470A5 JP 2025016020 A JP2025016020 A JP 2025016020A JP 2025016020 A JP2025016020 A JP 2025016020A JP 2025072470 A5 JP2025072470 A5 JP 2025072470A5
Authority
JP
Japan
Prior art keywords
onui
seq
mutations
variant
targeting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2025016020A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025072470A (ja
Filing date
Publication date
Priority claimed from PCT/US2019/065211 external-priority patent/WO2020123371A2/en
Application filed filed Critical
Publication of JP2025072470A publication Critical patent/JP2025072470A/ja
Publication of JP2025072470A5 publication Critical patent/JP2025072470A5/ja
Pending legal-status Critical Current

Links

JP2025016020A 2018-12-10 2025-02-03 ホーミングエンドヌクレアーゼバリアント Pending JP2025072470A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862777476P 2018-12-10 2018-12-10
US62/777,476 2018-12-10
PCT/US2019/065211 WO2020123371A2 (en) 2018-12-10 2019-12-09 Homing endonuclease variants
JP2021532870A JP2022513750A (ja) 2018-12-10 2019-12-09 ホーミングエンドヌクレアーゼバリアント

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2021532870A Division JP2022513750A (ja) 2018-12-10 2019-12-09 ホーミングエンドヌクレアーゼバリアント

Publications (2)

Publication Number Publication Date
JP2025072470A JP2025072470A (ja) 2025-05-09
JP2025072470A5 true JP2025072470A5 (https=) 2025-08-08

Family

ID=71076132

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021532870A Pending JP2022513750A (ja) 2018-12-10 2019-12-09 ホーミングエンドヌクレアーゼバリアント
JP2025016020A Pending JP2025072470A (ja) 2018-12-10 2025-02-03 ホーミングエンドヌクレアーゼバリアント

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2021532870A Pending JP2022513750A (ja) 2018-12-10 2019-12-09 ホーミングエンドヌクレアーゼバリアント

Country Status (9)

Country Link
US (2) US12404500B2 (https=)
EP (1) EP3893922A4 (https=)
JP (2) JP2022513750A (https=)
KR (1) KR20210102925A (https=)
CN (1) CN113329760A (https=)
AU (1) AU2019397364B8 (https=)
CA (1) CA3122278A1 (https=)
IL (1) IL283720B2 (https=)
WO (1) WO2020123371A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024503249A (ja) * 2020-12-21 2024-01-25 2セブンティ バイオ インコーポレイテッド 部位特異的変異導入のための組成物及び方法

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
GB8918616D0 (en) 1989-08-15 1989-09-27 Univ Glasgow Herpes simplex virus type 1 mutant
US5804413A (en) 1992-07-31 1998-09-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains for gene transfer
GB9415319D0 (en) 1994-07-29 1994-09-21 Medical Res Council HSV viral vector
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US6093570A (en) 1995-06-07 2000-07-25 The University Of North Carolina At Chapel Hill Helper virus-free AAV production
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
AU8605598A (en) 1997-07-31 1999-02-22 University Of Pittsburgh Targeted hsv vectors
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
FR2777909B1 (fr) 1998-04-24 2002-08-02 Pasteur Institut Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex
US6692736B2 (en) 2000-03-24 2004-02-17 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
ATE318923T1 (de) 2000-06-01 2006-03-15 Univ North Carolina Doppelsträngige parvovirus-vektoren
FR2872170B1 (fr) 2004-06-25 2006-11-10 Centre Nat Rech Scient Cnrse Lentivirus non interactif et non replicatif, preparation et utilisations
JP5136766B2 (ja) 2004-12-15 2013-02-06 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル キメラベクター
WO2007049095A1 (en) 2005-10-25 2007-05-03 Cellectis Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
CN101679959A (zh) * 2007-02-19 2010-03-24 赛莱克蒂斯公司 具有新的底物特异性的laglidadg归巢核酸内切酶变体及其用途
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
EP2188384B1 (en) 2007-09-27 2015-07-15 Sangamo BioSciences, Inc. Rapid in vivo identification of biologically active nucleases
EP2215223B1 (en) 2007-10-31 2013-05-01 Precision Biosciences, Inc. Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
WO2010093784A2 (en) 2009-02-11 2010-08-19 The University Of North Carolina At Chapel Hill Modified virus vectors and methods of making and using the same
EP2524037B1 (en) 2010-01-12 2018-05-16 The University Of North Carolina At Chapel Hill Restrictive inverted terminal repeats for viral vectors
US9169492B2 (en) 2010-02-05 2015-10-27 The University Of North Carolina At Chapel Hill Compositions and methods for enhanced parvovirus transduction
US20110256607A1 (en) * 2010-04-16 2011-10-20 Georg Hausner Homing endonucleases
US20140148361A1 (en) 2010-06-07 2014-05-29 Barry L. Stoddard Generation and Expression of Engineered I-ONUI Endonuclease and Its Homologues and Uses Thereof
US20130337454A1 (en) 2010-10-27 2013-12-19 Philippe Duchateau Method for increasing the efficiency of double-strand break-induced mutagenesis
US8673557B2 (en) 2011-02-28 2014-03-18 Seattle Children's Research Institute Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
US20150166969A1 (en) * 2012-02-24 2015-06-18 Fred Hutchinson Cancer Research Center Compositions and methods for the treatment of hemoglobinopathies
US20150017136A1 (en) 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
BR112014029417B1 (pt) 2012-05-25 2023-03-07 Cellectis Método ex vivo para a preparação de células t para imunoterapia
US20140015679A1 (en) 2012-07-15 2014-01-16 Green Badge LLC Specialty Plant Moisture Sensing
AU2014266833B2 (en) 2013-05-13 2020-07-02 Cellectis Methods for engineering highly active T cell for immunotherapy
ES2716867T3 (es) 2013-05-31 2019-06-17 Cellectis Sa Endonucleasa de asentamiento LAGLIDADG que escinde el gen de receptor de células T alfa y usos de la misma
CA2913871C (en) 2013-05-31 2021-07-13 Cellectis A laglidadg homing endonuclease cleaving the c-c chemokine receptor type-5 (ccr5) gene and uses thereof
EP3925618A1 (en) 2013-07-29 2021-12-22 2seventy bio, Inc. Multipartite signaling proteins and uses thereof
CN112552401B (zh) 2013-09-13 2023-08-25 广州百济神州生物制药有限公司 抗pd1抗体及其作为治疗剂与诊断剂的用途
JP2019509738A (ja) 2016-03-11 2019-04-11 ブルーバード バイオ, インコーポレイテッド ゲノム編集された免疫エフェクター細胞
US20190161530A1 (en) 2016-04-07 2019-05-30 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
WO2018022619A1 (en) 2016-07-25 2018-02-01 Bluebird Bio, Inc. Bcl11a homing endonuclease variants, compositions, and methods of use
MA45996A (fr) 2016-08-16 2021-06-02 Bluebird Bio Inc Variants d'endonucléase de homing du récepteur alpha de l'il-10, compositions et méthodes d'utilisation associées
AU2017312132A1 (en) 2016-08-19 2019-03-21 Bluebird Bio, Inc. Genome editing enhancers
WO2018039333A1 (en) * 2016-08-23 2018-03-01 Bluebird Bio, Inc. Tim3 homing endonuclease variants, compositions, and methods of use
KR102451510B1 (ko) * 2016-09-08 2022-10-07 2세븐티 바이오, 인코포레이티드 Pd-1 호밍 엔도뉴클레아제 변이체, 조성물 및 사용 방법
US11591582B2 (en) * 2016-10-11 2023-02-28 2Seventy Bio, Inc. TCRα homing endonuclease variants
MA46543A (fr) 2016-10-17 2019-08-21 Bluebird Bio Inc Variants de l'endonucléase tgfbéta r2, compositions et procédés d'utilisation
CN106749666B (zh) 2016-12-22 2018-12-25 福州大学 一种人源程序性死亡受体hPD-1单克隆抗体
CN106939049B (zh) 2017-04-20 2019-10-01 苏州思坦维生物技术股份有限公司 拮抗抑制人pd-1抗原与其配体结合的单克隆抗体及其制备方法与应用
MA48797A (fr) 2017-05-25 2020-04-08 Bluebird Bio Inc Variants de l'endonucléase cblb , compositions et procédés d'utilisation
US11779654B2 (en) * 2017-10-04 2023-10-10 2Seventy Bio, Inc. PCSK9 endonuclease variants, compositions, and methods of use
WO2020072059A1 (en) * 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
IL283724B1 (en) 2018-12-10 2026-02-01 Genetix Biotherapeutics Inc pdcd-1 homing endonuclease variants

Similar Documents

Publication Publication Date Title
JP2025072470A5 (https=)
US20200040328A1 (en) Novel anti-crispr genes and proteins and methods of use
James et al. Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa
Cazares et al. Core and accessory genome architecture in a group of Pseudomonas aeruginosa Mu-like phages
Rivas-Marín et al. Development of genetic tools for the manipulation of the planctomycetes
JP2021097671A5 (https=)
CN107475228B (zh) 一种底物特异性提高的角蛋白酶突变体及其制备方法
JP7672745B2 (ja) 広域溶解活性を有する抗菌ペプチドP104、リシンLysP53及びその応用
WO2016138534A3 (en) Antisense-induced exon2 inclusion in acid alpha-glucosidase
JP2005058227A5 (https=)
Wang et al. The Escherichia coli O111 and Salmonella enterica O35 gene clusters: gene clusters encoding the same colitose-containing O antigen are highly conserved
CN103710321A (zh) 烟酰胺单核苷酸腺苷转移酶突变体及其编码基因和应用
EA201170917A1 (ru) Ген, кодирующий мутантную глюкокиназу человека, кодируемый им фермент, рекомбинантные векторы и хозяева, фармацевтические композиции и их применения, способы лечения и предупреждения болезней
Akanuma et al. Further improvement of the thermal stability of a partially stabilized Bacillus subtilis 3‐isopropylmalate dehydrogenase variant by random and site‐directed mutagenesis
JP2025516090A5 (https=)
WO2015088204A1 (ko) L-라이신 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 l-라이신을 생산하는 방법
JP2018535693A5 (https=)
WO2024073612A3 (en) Therapeutic nucleic acids and methods of use thereof
JP2022528696A5 (https=)
CN110628742A (zh) 转氨酶突变体及其应用
JP2002513574A5 (https=)
JP2006519604A5 (https=)
WO2004042046A3 (de) Wirksame und stabile dna-enzyme
WO2017010833A1 (ko) 신규 알파-1,3-글루카나제
Prajapati et al. Draft genome sequence of a thermostable, alkaliphilic α-amylase and protease producing Bacillus amyloliquefaciens strain KCP2