JP2024539629A5 - - Google Patents

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Publication number
JP2024539629A5
JP2024539629A5 JP2024522206A JP2024522206A JP2024539629A5 JP 2024539629 A5 JP2024539629 A5 JP 2024539629A5 JP 2024522206 A JP2024522206 A JP 2024522206A JP 2024522206 A JP2024522206 A JP 2024522206A JP 2024539629 A5 JP2024539629 A5 JP 2024539629A5
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JP
Japan
Prior art keywords
dsrna agent
pharmaceutically acceptable
acceptable salt
group
linkers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2024522206A
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English (en)
Japanese (ja)
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JP2024539629A (ja
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Publication date
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Priority claimed from PCT/US2022/046668 external-priority patent/WO2023064530A1/en
Publication of JP2024539629A publication Critical patent/JP2024539629A/ja
Publication of JP2024539629A5 publication Critical patent/JP2024539629A5/ja
Pending legal-status Critical Current

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JP2024522206A 2021-10-15 2022-10-14 肝外デリバリーｉＲＮＡ組成物およびその使用方法 Pending JP2024539629A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163255984P 2021-10-15 2021-10-15
US63/255,984 2021-10-15
PCT/US2022/046668 WO2023064530A1 (en) 2021-10-15 2022-10-14 Extra-hepatic delivery irna compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2024539629A JP2024539629A (ja) 2024-10-29
JP2024539629A5 true JP2024539629A5 (OSRAM) 2025-10-22

Family

ID=84360072

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024522206A Pending JP2024539629A (ja) 2021-10-15 2022-10-14 肝外デリバリーｉＲＮＡ組成物およびその使用方法

Country Status (10)

Country Link
US (1) US20240360455A1 (OSRAM)
EP (1) EP4416284A1 (OSRAM)
JP (1) JP2024539629A (OSRAM)
KR (1) KR20240101590A9 (OSRAM)
CN (1) CN118369427A (OSRAM)
AU (1) AU2022364838A1 (OSRAM)
CA (1) CA3234887A1 (OSRAM)
IL (1) IL311864A (OSRAM)
MX (1) MX2024004437A (OSRAM)
WO (1) WO2023064530A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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UY40699A (es) 2023-04-05 2024-08-30 Ionis Pharmaceuticals Inc Compuestos y métodos para reducir la expresión de pln
CN121793987A (zh) 2023-06-30 2026-04-03 艾维迪提生物科学公司 使用pln靶向性抗体-寡核苷酸缀合物的组合物和方法
IL326940A (en) 2023-09-21 2026-05-01 Alnylam Pharmaceuticals Inc Activin A Receptor Type 1C (ACVR1C) IRNA Compositions and Methods of Using Them
WO2025073871A1 (en) 2023-10-03 2025-04-10 Bicycletx Limited Bicyclic peptide ligand complexes specific for tfr1
WO2025259743A1 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dual conjugate compounds for extrahepatic delivery
WO2025259747A2 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof
WO2026007966A1 (zh) * 2024-07-01 2026-01-08 武汉人福创新药物研发中心有限公司 抑制INHBE基因表达的siRNA、偶联物及其应用
CN121450642A (zh) * 2024-08-01 2026-02-03 北京尧景基因技术有限公司 抑制PLN基因表达的siRNA及其缀合物和应用
WO2026046355A1 (zh) * 2024-08-31 2026-03-05 齐鲁制药有限公司 dsRNA分子、药物组合物及其在肝外递送中的应用

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