JP2024535380A - Ｅｇｆｒ阻害剤の多形形態 - Google Patents

Ｅｇｆｒ阻害剤の多形形態 Download PDF

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Publication number
JP2024535380A
JP2024535380A JP2024518581A JP2024518581A JP2024535380A JP 2024535380 A JP2024535380 A JP 2024535380A JP 2024518581 A JP2024518581 A JP 2024518581A JP 2024518581 A JP2024518581 A JP 2024518581A JP 2024535380 A JP2024535380 A JP 2024535380A
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JP
Japan
Prior art keywords
compound
polymorph
cancer
suspension
equilibration
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Pending
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JP2024518581A
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English (en)
Japanese (ja)
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JP2024535380A5 (https=
Inventor
ヴェルニエ，ジャン－ミシェル
ブラッター，フリッツ
ライナー マイアー，アクセル
トゥフィッリ，ニコリーノ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maier Axel Rainer
Tufilli Nicolino
Erasca Inc
Original Assignee
Maier Axel Rainer
Tufilli Nicolino
Erasca Inc
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Publication date
Application filed by Maier Axel Rainer, Tufilli Nicolino, Erasca Inc filed Critical Maier Axel Rainer
Publication of JP2024535380A publication Critical patent/JP2024535380A/ja
Publication of JP2024535380A5 publication Critical patent/JP2024535380A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024518581A 2021-09-23 2022-09-23 Ｅｇｆｒ阻害剤の多形形態 Pending JP2024535380A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163247774P 2021-09-23 2021-09-23
US63/247,774 2021-09-23
PCT/US2022/044475 WO2023049312A1 (en) 2021-09-23 2022-09-23 Egfr inhibitor polymorph forms

Publications (2)

Publication Number Publication Date
JP2024535380A true JP2024535380A (ja) 2024-09-30
JP2024535380A5 JP2024535380A5 (https=) 2025-09-29

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ID=85721153

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JP2024518581A Pending JP2024535380A (ja) 2021-09-23 2022-09-23 Ｅｇｆｒ阻害剤の多形形態

Country Status (10)

Country Link
US (1) US12545686B2 (https=)
EP (1) EP4405360A4 (https=)
JP (1) JP2024535380A (https=)
KR (1) KR20250005041A (https=)
CN (1) CN119343350A (https=)
AU (1) AU2022350669A1 (https=)
CA (1) CA3233057A1 (https=)
IL (1) IL311616A (https=)
MX (1) MX2024003495A (https=)
WO (1) WO2023049312A1 (https=)

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US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
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WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

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Also Published As

Publication number Publication date
US12545686B2 (en) 2026-02-10
CN119343350A (zh) 2025-01-21
AU2022350669A1 (en) 2024-04-04
EP4405360A1 (en) 2024-07-31
CA3233057A1 (en) 2023-03-30
EP4405360A4 (en) 2025-08-20
IL311616A (en) 2024-05-01
MX2024003495A (es) 2025-01-09
US20240287088A1 (en) 2024-08-29
WO2023049312A1 (en) 2023-03-30
KR20250005041A (ko) 2025-01-09

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