|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
CA1340323C
(en)
|
1988-09-20 |
1999-01-19 |
Arnold E. Hampel |
Rna catalyst for cleaving specific rna sequences
|
|
GB8822492D0
(en)
|
1988-09-24 |
1988-10-26 |
Considine J |
Apparatus for removing tumours from hollow organs of body
|
|
AU637800B2
(en)
|
1989-08-31 |
1993-06-10 |
City Of Hope |
Chimeric dna-rna catalytic sequences
|
|
US6365730B1
(en)
|
1990-06-19 |
2002-04-02 |
Gene Shears Pty. Limited |
DNA-Armed ribozymes and minizymes
|
|
US5789573A
(en)
|
1990-08-14 |
1998-08-04 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
|
|
ES2061416T3
(es)
|
1990-10-12 |
1997-03-01 |
Max Planck Gesellschaft |
Ribozimas modificadas.
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
EP0642589A4
(en)
|
1992-05-11 |
1997-05-21 |
Ribozyme Pharm Inc |
METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
|
|
EP0786522A2
(en)
|
1992-07-17 |
1997-07-30 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecules for treatment of stenotic conditions
|
|
IL108367A0
(en)
|
1993-01-27 |
1994-04-12 |
Hektoen Inst For Medical Resea |
Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
|
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
|
US5591317A
(en)
|
1994-02-16 |
1997-01-07 |
Pitts, Jr.; M. Michael |
Electrostatic device for water treatment
|
|
US5631359A
(en)
|
1994-10-11 |
1997-05-20 |
Ribozyme Pharmaceuticals, Inc. |
Hairpin ribozymes
|
|
WO1996011266A2
(en)
|
1994-10-05 |
1996-04-18 |
Amgen Inc. |
Method for inhibiting smooth muscle cell proliferation and oligonucleotides for use therein
|
|
US5783683A
(en)
|
1995-01-10 |
1998-07-21 |
Genta Inc. |
Antisense oligonucleotides which reduce expression of the FGFRI gene
|
|
US5747470A
(en)
|
1995-06-07 |
1998-05-05 |
Gen-Probe Incorporated |
Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
|
|
US5763263A
(en)
|
1995-11-27 |
1998-06-09 |
Dehlinger; Peter J. |
Method and apparatus for producing position addressable combinatorial libraries
|
|
CA2518475C
(en)
|
2003-03-07 |
2014-12-23 |
Alnylam Pharmaceuticals, Inc. |
Irna agents comprising asymmetrical modifications
|
|
ES2702942T3
(es)
|
2003-04-17 |
2019-03-06 |
Alnylam Pharmaceuticals Inc |
Agentes de ARNi modificados
|
|
AU2006279906B2
(en)
|
2005-08-10 |
2012-05-10 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
|
|
US20070213292A1
(en)
|
2005-08-10 |
2007-09-13 |
The Rockefeller University |
Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
|
|
WO2009073809A2
(en)
|
2007-12-04 |
2009-06-11 |
Alnylam Pharmaceuticals, Inc. |
Carbohydrate conjugates as delivery agents for oligonucleotides
|
|
CA3131967A1
(en)
|
2010-12-29 |
2012-07-05 |
F. Hoffman-La Roche Ag |
Small molecule conjugates for intracellular delivery of nucleic acids
|
|
BR112013026345A2
(pt)
*
|
2011-04-13 |
2019-04-24 |
Merck Sharp & Dohe Corp. |
composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv
|
|
US8577565B2
(en)
|
2011-12-16 |
2013-11-05 |
GM Global Technology Operations LLC |
Limiting branch pressure to a solenoid valve in a fluid circuit
|
|
WO2015006740A2
(en)
|
2013-07-11 |
2015-01-15 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotide-ligand conjugates and process for their preparation
|
|
US10030042B2
(en)
*
|
2014-03-16 |
2018-07-24 |
MiRagen Therapeutics, Inc. |
Synthesis of bicyclic nucleosides
|
|
DK3569711T3
(da)
|
2014-12-15 |
2021-02-22 |
Dicerna Pharmaceuticals Inc |
Ligandmodificerede dobbeltstrengede nukleinsyrer
|
|
CN106366146A
(zh)
*
|
2015-07-13 |
2017-02-01 |
中科云和(北京)生物医药科技有限公司 |
2’-双烷基取代的核苷类似物及用途
|
|
MX2018015109A
(es)
|
2016-06-06 |
2019-04-22 |
Arrowhead Pharmaceuticals Inc |
Nucleotidos modificados con 5'-ciclo-fosfonato.
|
|
JP7249080B2
(ja)
|
2016-08-23 |
2023-03-30 |
ディセルナ ファーマシューティカルズ インコーポレイテッド |
可逆的に修飾されたオリゴヌクレオチドを含む組成物及びその使用
|
|
HUE059718T2
(hu)
|
2016-09-02 |
2022-12-28 |
Dicerna Pharmaceuticals Inc |
4'-foszfát analógok és azokat tartalmazó oligonukleotidok
|
|
AU2020358016A1
(en)
*
|
2019-10-02 |
2022-04-21 |
Dicerna Pharmaceuticals, Inc. |
Chemical modifications of small interfering RNA with minimal fluorine content
|