JP2024528029A5 - - Google Patents

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Publication number
JP2024528029A5
JP2024528029A5 JP2024505205A JP2024505205A JP2024528029A5 JP 2024528029 A5 JP2024528029 A5 JP 2024528029A5 JP 2024505205 A JP2024505205 A JP 2024505205A JP 2024505205 A JP2024505205 A JP 2024505205A JP 2024528029 A5 JP2024528029 A5 JP 2024528029A5
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JP
Japan
Prior art keywords
cancer
optionally
nucleic acid
acid molecule
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024505205A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024528029A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2022/057006 external-priority patent/WO2023007431A1/en
Publication of JP2024528029A publication Critical patent/JP2024528029A/ja
Publication of JP2024528029A5 publication Critical patent/JP2024528029A5/ja
Pending legal-status Critical Current

Links

JP2024505205A 2021-07-29 2022-07-28 メソテリンを特異的に標的とする操作された免疫細胞及びその使用 Pending JP2024528029A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163227116P 2021-07-29 2021-07-29
US63/227,116 2021-07-29
PCT/IB2022/057006 WO2023007431A1 (en) 2021-07-29 2022-07-28 Engineered immune cell that specifically targets mesothelin and uses thereof

Publications (2)

Publication Number Publication Date
JP2024528029A JP2024528029A (ja) 2024-07-26
JP2024528029A5 true JP2024528029A5 (https=) 2025-08-01

Family

ID=83457041

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024505205A Pending JP2024528029A (ja) 2021-07-29 2022-07-28 メソテリンを特異的に標的とする操作された免疫細胞及びその使用

Country Status (9)

Country Link
US (1) US20240350627A1 (https=)
EP (1) EP4377335A1 (https=)
JP (1) JP2024528029A (https=)
KR (1) KR20240040068A (https=)
CN (1) CN117642421A (https=)
AU (1) AU2022318416A1 (https=)
CA (1) CA3227581A1 (https=)
TW (1) TW202321287A (https=)
WO (1) WO2023007431A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112771166B (zh) * 2018-08-31 2025-03-04 诺伊尔免疫生物科技株式会社 表达car的t细胞和car表达载体
KR102770127B1 (ko) * 2020-10-28 2025-02-21 주식회사 티에스디라이프사이언스 이종 면역세포에 대한 화학주성을 유도하는 형질전환된 면역세포

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036945A (en) 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4694778A (en) 1984-05-04 1987-09-22 Anicon, Inc. Chemical vapor deposition wafer boat
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
JP2928287B2 (ja) 1988-09-29 1999-08-03 協和醗酵工業株式会社 新規ポリペプチド
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US9272002B2 (en) 2011-10-28 2016-03-01 The Trustees Of The University Of Pennsylvania Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
BR112014029417B1 (pt) 2012-05-25 2023-03-07 Cellectis Método ex vivo para a preparação de células t para imunoterapia
AU2015214145A1 (en) 2014-02-04 2016-08-25 Kite Pharma. Inc. Methods for producing autologous T cells useful to treat B cell malignancies and other cancers and compositions thereof
EP4205749A1 (en) 2014-07-31 2023-07-05 Novartis AG Subset-optimized chimeric antigen receptor-containing cells
SI3597742T1 (sl) 2014-10-09 2022-11-30 Yamaguchi University CAR ekspresijski vektor in T celice, ki izražajo CAR
CA3017442A1 (en) 2016-03-17 2017-09-21 Yamaguchi University Immunocompetent cell and expression vector expressing regulatory factors of immune function
KR102790597B1 (ko) * 2017-10-10 2025-04-07 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 메모리 기능을 갖는 t세포 또는 b세포의 증강제, 악성 종양 재발 억제제 및 t세포 또는 b세포에 메모리 기능을 유도하는 유도제
WO2019124468A1 (ja) 2017-12-24 2019-06-27 ノイルイミューン・バイオテック株式会社 ヒトメソセリンを特異的に認識する細胞表面分子、il-7、及びccl19を発現する免疫担当細胞

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