JP2024519614A - Ｐｒａｍｅ特異的ｔ細胞受容体とキメラ補助刺激受容体との組合せ - Google Patents

Ｐｒａｍｅ特異的ｔ細胞受容体とキメラ補助刺激受容体との組合せ Download PDF

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JP2024519614A
JP2024519614A JP2023568236A JP2023568236A JP2024519614A JP 2024519614 A JP2024519614 A JP 2024519614A JP 2023568236 A JP2023568236 A JP 2023568236A JP 2023568236 A JP2023568236 A JP 2023568236A JP 2024519614 A JP2024519614 A JP 2024519614A
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tcr
cells
seq
cell
amino acid
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JP2024519614A5 (enExample
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サイラー，ナジャ
サルヴァーモーサー，メラニー
ソンマーメイヤー，ダニエル
ワイルド，スザンヌ
フェッツァー，イナ
ビュルデック，マヤ
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メディジーン イミュノテラピーズ ゲーエムベーハー
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/36—Immune checkpoint inhibitors
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/427—PRAME
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70521—CD28, CD152
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    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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JP2023568236A 2021-05-07 2022-05-06 Ｐｒａｍｅ特異的ｔ細胞受容体とキメラ補助刺激受容体との組合せ Pending JP2024519614A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21172722.7 2021-05-07
EP21172722 2021-05-07
PCT/EP2022/062338 WO2022234116A1 (en) 2021-05-07 2022-05-06 Combination of prame specific t cell receptors and chimeric co-stimulatory receptors

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JP2024519614A true JP2024519614A (ja) 2024-05-20
JP2024519614A5 JP2024519614A5 (enExample) 2025-05-14

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US (1) US20240277762A1 (enExample)
EP (1) EP4334331A1 (enExample)
JP (1) JP2024519614A (enExample)
KR (1) KR20240005865A (enExample)
CN (1) CN117279931A (enExample)
AU (1) AU2022270947A1 (enExample)
CA (1) CA3215758A1 (enExample)
WO (1) WO2022234116A1 (enExample)

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KR20250133715A (ko) 2023-01-06 2025-09-08 이뮤노코어 리미티드 Prame 펩타이드-hla 복합체에 대한 결합 분자
WO2025219541A1 (en) * 2024-04-19 2025-10-23 Medigene Immunotherapies Gmbh Constant uni-tabs
EP4635976A1 (en) * 2024-04-19 2025-10-22 Medigene Immunotherapies GmbH Constant uni-tabs

Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2020529191A (ja) * 2017-06-20 2020-10-08 イムノコア リミテッド Ｔ細胞レセプター
JP2023503416A (ja) * 2019-11-18 2023-01-30 バイオエヌテック エスエー Ｐｒａｍｅ ｔｃｒ受容体及びその使用

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US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
US4851341A (en) 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
EP2006376A1 (en) 2007-06-21 2008-12-24 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Fusion protein comprising a caspase domain and a nuclear hormone receptor binding domain and methods and uses thereof
CN103965361B (zh) * 2013-02-06 2018-10-30 上海细胞治疗工程技术研究中心集团有限公司 一种t细胞信号的嵌合分子转换器及其用途
AU2016230828B2 (en) * 2015-03-10 2020-10-22 ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof
JP6989138B2 (ja) * 2016-06-17 2022-01-05 メディジーン イミュノテラピーズ ゲーエムベーハー Ｔ細胞受容体及びその使用
WO2018119198A1 (en) * 2016-12-22 2018-06-28 Windmil Therapeutics, Inc. Compositions and methods for modulating the immune system
US11738047B2 (en) * 2017-12-12 2023-08-29 The Trustees Of The University Of Pennsylvania Genetically modified immune cells targeting NY-ESO-1 and methods of use thereof
AU2018395397A1 (en) * 2017-12-28 2020-08-06 Gritstone Bio, Inc. Antigen-binding proteins targeting shared antigens
CN108794619B (zh) * 2018-05-31 2021-09-17 郑州大学 一种高亲和pd-1蛋白突变体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020529191A (ja) * 2017-06-20 2020-10-08 イムノコア リミテッド Ｔ細胞レセプター
JP2023503416A (ja) * 2019-11-18 2023-01-30 バイオエヌテック エスエー Ｐｒａｍｅ ｔｃｒ受容体及びその使用

Non-Patent Citations (1)

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Title
CANCER IMMUNOL.IMMUNOTHRAP., vol. 69, JPN6026023336, 2020, pages 677 - 682, ISSN: 0005880844 *

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US20240277762A1 (en) 2024-08-22
CN117279931A (zh) 2023-12-22
AU2022270947A1 (en) 2023-11-16
KR20240005865A (ko) 2024-01-12
EP4334331A1 (en) 2024-03-13
WO2022234116A1 (en) 2022-11-10
CA3215758A1 (en) 2022-11-10

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