JP2024519140A5 - - Google Patents
Info
- Publication number
- JP2024519140A5 JP2024519140A5 JP2023572596A JP2023572596A JP2024519140A5 JP 2024519140 A5 JP2024519140 A5 JP 2024519140A5 JP 2023572596 A JP2023572596 A JP 2023572596A JP 2023572596 A JP2023572596 A JP 2023572596A JP 2024519140 A5 JP2024519140 A5 JP 2024519140A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- heteroaryl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163194138P | 2021-05-27 | 2021-05-27 | |
| US63/194,138 | 2021-05-27 | ||
| US202163203667P | 2021-07-27 | 2021-07-27 | |
| US63/203,667 | 2021-07-27 | ||
| US202163290587P | 2021-12-16 | 2021-12-16 | |
| US63/290,587 | 2021-12-16 | ||
| PCT/CA2022/050864 WO2022246576A1 (en) | 2021-05-27 | 2022-05-27 | Camptothecin analogues, conjugates and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024519140A JP2024519140A (ja) | 2024-05-08 |
| JP2024519140A5 true JP2024519140A5 (enExample) | 2025-08-01 |
Family
ID=84229147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023572596A Pending JP2024519140A (ja) | 2021-05-27 | 2022-05-27 | カンプトテシン類似体、複合体及び使用の方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240269309A1 (enExample) |
| EP (1) | EP4347601A4 (enExample) |
| JP (1) | JP2024519140A (enExample) |
| KR (1) | KR20240031235A (enExample) |
| AU (1) | AU2022282813A1 (enExample) |
| BR (1) | BR112023024433A2 (enExample) |
| CA (1) | CA3177067A1 (enExample) |
| IL (1) | IL308734A (enExample) |
| MX (1) | MX2023013738A (enExample) |
| WO (1) | WO2022246576A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024510435A (ja) | 2021-03-18 | 2024-03-07 | シージェン インコーポレイテッド | 生体活性化合物の内部移行複合体からの選択的薬物放出 |
| JP2024532768A (ja) * | 2021-08-19 | 2024-09-10 | ハイナン シムセレ ザイミン ファーマシューティカル カンパニー リミテッド | カンプトテシン誘導体、その薬物組成物およびその応用 |
| CN118414339A (zh) * | 2021-12-16 | 2024-07-30 | 迈威(上海)生物科技股份有限公司 | 一种喜树碱类化合物及其偶联物 |
| KR20250004952A (ko) * | 2022-03-17 | 2025-01-08 | 씨젠 인크. | 캄프토테신 접합체 |
| KR20240162575A (ko) | 2022-03-25 | 2024-11-15 | 자임워크스 비씨 인코포레이티드 | 엽산 수용체 알파를 표적화하는 항체-약물 접합체 및 사용 방법 |
| JP2025515988A (ja) * | 2022-05-13 | 2025-05-23 | シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド | カンプトテシン化合物、その調製方法及びその使用 |
| CN116675727A (zh) * | 2022-12-28 | 2023-09-01 | 广州医科大学 | 一种以不保护氨基酸为氨组分合成酰胺和/或多肽的方法 |
| CN116270641A (zh) * | 2023-03-09 | 2023-06-23 | 兰州大学 | 喜树碱类衍生物在制备治疗膀胱癌药物中的应用 |
| EP4720075A1 (en) * | 2023-05-26 | 2026-04-08 | NJ Bio, Inc. | Topoisomerase inhibitors, methods of making, and methods of use thereof |
| AU2024302681A1 (en) * | 2023-06-13 | 2026-01-15 | Chengdu Brilliant Pharmaceutical Co., Ltd. | Camptothecin derivative for treating or preventing cancer, and antibody-drug conjugate thereof |
| EP4587063A1 (en) * | 2023-10-11 | 2025-07-23 | Minerva Biotechnologies Corporation | Anti-muc1* antibody drug complexes and uses thereof |
| IL327670A (en) | 2023-10-11 | 2026-06-01 | Antikor Biopharma Ltd | Antibodies, conjugates, and uses thereof |
| CN122122183A (zh) * | 2023-10-19 | 2026-05-29 | 酵活英属哥伦比亚有限公司 | 抗napi2b抗体-药物缀合物和使用方法 |
| WO2025235686A1 (en) * | 2024-05-07 | 2025-11-13 | Aarvik Therapeutics, Inc. | Fluorocamptothecin compounds, conjugates, and methods thereof |
| TW202604492A (zh) * | 2024-05-28 | 2026-02-01 | 南韓商韓美藥品股份有限公司 | 具有抗腫瘤活性的新型磺醯胺喜樹鹼衍生物和包含其的醫藥組成物 |
| WO2026145631A1 (zh) * | 2024-12-31 | 2026-07-09 | 上海复宏汉霖生物技术股份有限公司 | 一种配体-药物偶联物及制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136978A (en) * | 1993-06-30 | 2000-10-24 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
| JP2002255821A (ja) * | 2001-03-06 | 2002-09-11 | Yakult Honsha Co Ltd | 抗癌剤耐性癌に対する治療剤 |
| JP7527787B2 (ja) * | 2017-03-24 | 2024-08-05 | シージェン インコーポレイテッド | グルクロニド薬物－リンカーの調製のためのプロセスおよびその中間体 |
| RS64961B1 (sr) * | 2019-04-26 | 2024-01-31 | Immunogen Inc | Derivati kamptotecina |
| CN110128501A (zh) * | 2019-05-21 | 2019-08-16 | 北京海美源医药科技有限公司 | 一种靶向fap酶的喜树碱类化合物及其制备方法和应用 |
| PH12022500032A1 (en) * | 2020-06-19 | 2024-02-26 | Hangzhou Dac Biotech Co Ltd | Conjugates of a cell-binding molecule with camptothecin analogs |
| CN120093941A (zh) * | 2021-02-09 | 2025-06-06 | 苏州宜联生物医药有限公司 | 生物活性物偶联物及其制备方法和用途 |
| IL305886A (en) * | 2021-03-18 | 2023-11-01 | Seagen Inc | Selective release of drugs from internalized conjugates of biologically active compounds |
| CN117980327A (zh) * | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
-
2022
- 2022-05-27 KR KR1020237044336A patent/KR20240031235A/ko active Pending
- 2022-05-27 EP EP22810026.9A patent/EP4347601A4/en active Pending
- 2022-05-27 MX MX2023013738A patent/MX2023013738A/es unknown
- 2022-05-27 BR BR112023024433A patent/BR112023024433A2/pt unknown
- 2022-05-27 CA CA3177067A patent/CA3177067A1/en active Pending
- 2022-05-27 IL IL308734A patent/IL308734A/en unknown
- 2022-05-27 US US18/562,049 patent/US20240269309A1/en active Pending
- 2022-05-27 WO PCT/CA2022/050864 patent/WO2022246576A1/en not_active Ceased
- 2022-05-27 AU AU2022282813A patent/AU2022282813A1/en active Pending
- 2022-05-27 JP JP2023572596A patent/JP2024519140A/ja active Pending
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