JP2025510791A5 - - Google Patents
Info
- Publication number
- JP2025510791A5 JP2025510791A5 JP2024556478A JP2024556478A JP2025510791A5 JP 2025510791 A5 JP2025510791 A5 JP 2025510791A5 JP 2024556478 A JP2024556478 A JP 2024556478A JP 2024556478 A JP2024556478 A JP 2024556478A JP 2025510791 A5 JP2025510791 A5 JP 2025510791A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino acid
- seq
- acid sequence
- sequence described
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263324003P | 2022-03-25 | 2022-03-25 | |
| US63/324,003 | 2022-03-25 | ||
| US202263417250P | 2022-10-18 | 2022-10-18 | |
| US63/417,250 | 2022-10-18 | ||
| US202363450607P | 2023-03-07 | 2023-03-07 | |
| US63/450,607 | 2023-03-07 | ||
| PCT/CA2023/050406 WO2023178452A1 (en) | 2022-03-25 | 2023-03-24 | Antibody-drug conjugates targeting folate receptor alpha and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2025510791A JP2025510791A (ja) | 2025-04-15 |
| JP2025510791A5 true JP2025510791A5 (enExample) | 2025-09-26 |
| JP7877480B2 JP7877480B2 (ja) | 2026-06-22 |
Family
ID=88099491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024556478A Active JP7877480B2 (ja) | 2022-03-25 | 2023-03-24 | 葉酸受容体アルファを標的とする抗体－薬物コンジュゲート及び使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12433952B2 (enExample) |
| EP (1) | EP4499698A1 (enExample) |
| JP (1) | JP7877480B2 (enExample) |
| KR (1) | KR20240162575A (enExample) |
| AU (1) | AU2023239448A1 (enExample) |
| CA (1) | CA3245602A1 (enExample) |
| CL (1) | CL2024002860A1 (enExample) |
| CO (1) | CO2024012877A2 (enExample) |
| IL (1) | IL315393A (enExample) |
| MX (1) | MX2024011775A (enExample) |
| WO (1) | WO2023178452A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4623936A1 (en) * | 2022-11-22 | 2025-10-01 | Keymed Biosciences (Chengdu) Co., Ltd. | Fused ring compound, conjugate thereof and use thereof |
| EP4688787A1 (en) * | 2023-04-07 | 2026-02-11 | Innovent Biologics (Suzhou) Co., Ltd. | Antibody-drug conjugates of camptothecin derivatives and uses thereof |
| AU2024302681A1 (en) * | 2023-06-13 | 2026-01-15 | Chengdu Brilliant Pharmaceutical Co., Ltd. | Camptothecin derivative for treating or preventing cancer, and antibody-drug conjugate thereof |
| CN122122183A (zh) * | 2023-10-19 | 2026-05-29 | 酵活英属哥伦比亚有限公司 | 抗napi2b抗体-药物缀合物和使用方法 |
| AU2024380559A1 (en) | 2023-11-17 | 2026-06-04 | Mersana Therapeutics, Inc. | Treatment of cancer using b7-h4-targeted antibody-drug conjugates |
| WO2025235686A1 (en) * | 2024-05-07 | 2025-11-13 | Aarvik Therapeutics, Inc. | Fluorocamptothecin compounds, conjugates, and methods thereof |
| CN118791615B (zh) * | 2024-07-22 | 2025-03-21 | 上海生物制品研究所有限责任公司 | 抗FRα抗体或抗原结合片段、抗体偶联药物及其应用 |
| WO2026057740A1 (en) * | 2024-09-12 | 2026-03-19 | Astrazeneca Ab | Treatment of cancer with therapeutic binding molecules |
| WO2026151884A1 (en) | 2025-01-09 | 2026-07-16 | Mersana Therapeutics, Inc. | Treatment of cancer using b7-h4-targeted antibody-drug conjugates |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9402934D0 (en) | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
| JP2002255821A (ja) | 2001-03-06 | 2002-09-11 | Yakult Honsha Co Ltd | 抗癌剤耐性癌に対する治療剤 |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| CN103429620B (zh) | 2010-11-05 | 2018-03-06 | 酵活有限公司 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
| US9574010B2 (en) | 2011-11-04 | 2017-02-21 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
| JP7527787B2 (ja) | 2017-03-24 | 2024-08-05 | シージェン インコーポレイテッド | グルクロニド薬物－リンカーの調製のためのプロセスおよびその中間体 |
| CN111936169A (zh) | 2018-04-06 | 2020-11-13 | 西雅图遗传学公司 | 喜树碱肽缀合物 |
| TWI920652B (zh) | 2018-06-07 | 2026-04-01 | 美商思進公司 | 喜樹鹼結合物 |
| KR20240104214A (ko) | 2019-03-29 | 2024-07-04 | 메디뮨 리미티드 | 화합물 및 이의 접합체 |
| RS64961B1 (sr) | 2019-04-26 | 2024-01-31 | Immunogen Inc | Derivati kamptotecina |
| CN110128501A (zh) | 2019-05-21 | 2019-08-16 | 北京海美源医药科技有限公司 | 一种靶向fap酶的喜树碱类化合物及其制备方法和应用 |
| CA3144784A1 (en) | 2019-06-24 | 2020-12-30 | Hangzhou Dac Biotech Co., Ltd | A conjugate of a cytotoxic agent to a cell binding molecule with branched linkers |
| KR20230026983A (ko) | 2020-05-11 | 2023-02-27 | 후닐라이프 바이오테크놀로지, 인코포레이트 | 알파-엔올라아제 항체들을 포함하는 약물 접합체 및 그의 이용 |
| PH12022500032A1 (en) | 2020-06-19 | 2024-02-26 | Hangzhou Dac Biotech Co Ltd | Conjugates of a cell-binding molecule with camptothecin analogs |
| CN114569735A (zh) | 2020-12-01 | 2022-06-03 | 泰州复旦张江药业有限公司 | 一种连接基-药物偶联物、制备方法及应用 |
| CN120093941A (zh) | 2021-02-09 | 2025-06-06 | 苏州宜联生物医药有限公司 | 生物活性物偶联物及其制备方法和用途 |
| KR20240031235A (ko) * | 2021-05-27 | 2024-03-07 | 자임워크스 비씨 인코포레이티드 | 캄프토테신 유사체, 접합체 및 사용 방법 |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
| EP4499697A4 (en) | 2022-03-25 | 2026-03-18 | Zymeworks Bc Inc | Anti-alpha folate receptor antibodies and methods of use |
-
2023
- 2023-03-24 KR KR1020247035390A patent/KR20240162575A/ko active Pending
- 2023-03-24 AU AU2023239448A patent/AU2023239448A1/en active Pending
- 2023-03-24 JP JP2024556478A patent/JP7877480B2/ja active Active
- 2023-03-24 CA CA3245602A patent/CA3245602A1/en active Pending
- 2023-03-24 EP EP23773421.5A patent/EP4499698A1/en active Pending
- 2023-03-24 IL IL315393A patent/IL315393A/en unknown
- 2023-03-24 WO PCT/CA2023/050406 patent/WO2023178452A1/en not_active Ceased
-
2024
- 2024-05-29 US US18/677,564 patent/US12433952B2/en active Active
- 2024-09-24 CO CONC2024/0012877A patent/CO2024012877A2/es unknown
- 2024-09-25 MX MX2024011775A patent/MX2024011775A/es unknown
- 2024-09-25 CL CL2024002860A patent/CL2024002860A1/es unknown
-
2025
- 2025-06-24 US US19/247,831 patent/US20250339552A1/en active Pending
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