JP2024514528A5 - - Google Patents
Info
- Publication number
- JP2024514528A5 JP2024514528A5 JP2023560919A JP2023560919A JP2024514528A5 JP 2024514528 A5 JP2024514528 A5 JP 2024514528A5 JP 2023560919 A JP2023560919 A JP 2023560919A JP 2023560919 A JP2023560919 A JP 2023560919A JP 2024514528 A5 JP2024514528 A5 JP 2024514528A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- cancer
- compound
- alkyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163170035P | 2021-04-02 | 2021-04-02 | |
| US63/170,035 | 2021-04-02 | ||
| PCT/US2022/023374 WO2022212958A1 (en) | 2021-04-02 | 2022-04-04 | Heterobivalent and homobivalent agents targeting fibroblast activation protein alpha and/or prostate-specific membrane antigen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024514528A JP2024514528A (ja) | 2024-04-02 |
| JP2024514528A5 true JP2024514528A5 (enExample) | 2025-04-14 |
Family
ID=83459940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023560919A Pending JP2024514528A (ja) | 2021-04-02 | 2022-04-04 | 線維芽細胞活性化タンパク質アルファおよび／または前立腺特異的膜抗原を標的とするヘテロ二価およびホモ二価薬剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240382629A1 (enExample) |
| EP (1) | EP4313049A4 (enExample) |
| JP (1) | JP2024514528A (enExample) |
| KR (1) | KR20230165818A (enExample) |
| CN (1) | CN117255685A (enExample) |
| AU (1) | AU2022252419A1 (enExample) |
| BR (1) | BR112023020123A2 (enExample) |
| CA (1) | CA3214070A1 (enExample) |
| IL (1) | IL307405A (enExample) |
| MX (2) | MX2023011599A (enExample) |
| WO (1) | WO2022212958A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
| IL319722A (en) | 2022-09-23 | 2025-05-01 | Nuclidium Ag | High purity radionuclides and their diagnostic and medical uses |
| WO2024078592A1 (zh) * | 2022-10-14 | 2024-04-18 | 无锡诺宇医药科技有限公司 | 靶向成纤维细胞活化蛋白的药物及其应用 |
| CN118852122A (zh) * | 2023-04-27 | 2024-10-29 | 中国科学院上海药物研究所 | 一种fap抑制剂和靶向fap核素探针及其应用 |
| US12440585B2 (en) * | 2023-09-12 | 2025-10-14 | Curadel Surgical Innovations, Inc. | Zwitterionic metal chelators |
| WO2025087229A1 (zh) * | 2023-10-27 | 2025-05-01 | 四川科伦博泰生物医药股份有限公司 | 一类喹啉结构的配体化合物及其放射性或非放射性标记物以及应用 |
| KR20250062978A (ko) * | 2023-10-31 | 2025-05-08 | 서울대학교병원 | 신규한 전립선 특이적 막 항원 리간드 및 이의 용도 |
| WO2025119908A1 (en) * | 2023-12-06 | 2025-06-12 | Bracco Imaging Spa | Psma-targeting fluorescent probes |
| WO2025163029A1 (en) | 2024-01-31 | 2025-08-07 | Bracco Imaging Spa | Psma-targeting bimodal and heterobivalent fluorescent agents |
| CN117700485B (zh) * | 2024-02-04 | 2024-04-16 | 山东大学 | 一种同时靶向psma和fap的化合物及其制备方法与应用 |
| WO2025167951A1 (zh) * | 2024-02-07 | 2025-08-14 | 苏州博锐创合医药有限公司 | 一种成纤维细胞活化蛋白抑制剂 |
| US12086990B1 (en) * | 2024-04-23 | 2024-09-10 | MultiFunctional Imaging LLC | Systems and methods for simultaneous imaging of multiple positron emission tomography (PET) tracers |
| CN118271393B (zh) * | 2024-05-31 | 2024-09-03 | 中国药科大学 | 一种靶向fap的二聚化合物及其探针和应用 |
| CN119080743B (zh) * | 2024-08-30 | 2026-01-06 | 北京师范大学 | 靶向psma和fap的双重靶向化合物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013107820A1 (en) * | 2012-01-17 | 2013-07-25 | Universiteit Antwerpen | Novel fap inhibitors |
| JP2021500373A (ja) * | 2017-10-23 | 2021-01-07 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 線維芽細胞活性化タンパク質α（ＦＡＰ−α）を標的とする撮像剤および放射線療法用薬剤 |
| PH12020551205A1 (en) * | 2018-02-06 | 2021-04-19 | Univ Heidelberg | Fap inhibitors |
| CN112088169A (zh) * | 2018-03-12 | 2020-12-15 | 纪念斯隆凯特琳癌症中心 | 双特异性结合剂及其用途 |
| KR20210116437A (ko) * | 2018-11-20 | 2021-09-27 | 코넬 유니버시티 | 방사성핵종의 마크로사이클릭 복합체 및 암의 방사선 요법에서의 이의 용도 |
| CN113292538A (zh) * | 2021-05-10 | 2021-08-24 | 北京肿瘤医院(北京大学肿瘤医院) | 靶向肿瘤相关成纤维细胞激活蛋白的化合物及其制备方法和应用与靶向fap的肿瘤显影剂 |
-
2022
- 2022-04-04 US US18/553,092 patent/US20240382629A1/en active Pending
- 2022-04-04 KR KR1020237037723A patent/KR20230165818A/ko active Pending
- 2022-04-04 IL IL307405A patent/IL307405A/en unknown
- 2022-04-04 WO PCT/US2022/023374 patent/WO2022212958A1/en not_active Ceased
- 2022-04-04 AU AU2022252419A patent/AU2022252419A1/en active Pending
- 2022-04-04 EP EP22782372.1A patent/EP4313049A4/en active Pending
- 2022-04-04 CA CA3214070A patent/CA3214070A1/en active Pending
- 2022-04-04 JP JP2023560919A patent/JP2024514528A/ja active Pending
- 2022-04-04 CN CN202280032772.6A patent/CN117255685A/zh active Pending
- 2022-04-04 MX MX2023011599A patent/MX2023011599A/es unknown
- 2022-04-04 BR BR112023020123A patent/BR112023020123A2/pt unknown
-
2023
- 2023-09-29 MX MX2026000948A patent/MX2026000948A/es unknown
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