JP2007516288A5 - - Google Patents
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- Publication number
- JP2007516288A5 JP2007516288A5 JP2006547204A JP2006547204A JP2007516288A5 JP 2007516288 A5 JP2007516288 A5 JP 2007516288A5 JP 2006547204 A JP2006547204 A JP 2006547204A JP 2006547204 A JP2006547204 A JP 2006547204A JP 2007516288 A5 JP2007516288 A5 JP 2007516288A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- chp
- moiety
- group
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 17
- -1 (1,1-dimethyl) Ethyl Chemical group 0.000 claims 7
- 230000001225 therapeutic effect Effects 0.000 claims 7
- 239000002184 metal Substances 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 5
- 150000003839 salts Chemical group 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 4
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 4
- 238000002059 diagnostic imaging Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000012216 imaging agent Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000005298 paramagnetic effect Effects 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 2
- 239000007822 coupling agent Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 claims 2
- 230000003439 radiotherapeutic effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- MFCMEDUYQNBCLZ-UHFFFAOYSA-N 2-[4,10-bis(carboxymethyl)-7-(1-phosphonoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OP(=O)(O)C(C)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 MFCMEDUYQNBCLZ-UHFFFAOYSA-N 0.000 claims 1
- DRNKIOIJTYLTSS-UHFFFAOYSA-N 2-[4,10-bis(carboxymethyl)-7-(phosphonomethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CP(O)(O)=O)CCN(CC(O)=O)CC1 DRNKIOIJTYLTSS-UHFFFAOYSA-N 0.000 claims 1
- VTJCFRRYUPRGDG-UHFFFAOYSA-N 2-[7-[bis[(2-methylpropan-2-yl)oxy]phosphorylmethyl]-4,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound CC(C)(C)OP(=O)(OC(C)(C)C)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 VTJCFRRYUPRGDG-UHFFFAOYSA-N 0.000 claims 1
- YEDUAINPPJYDJZ-UHFFFAOYSA-N 2-hydroxybenzothiazole Chemical compound C1=CC=C2SC(O)=NC2=C1 YEDUAINPPJYDJZ-UHFFFAOYSA-N 0.000 claims 1
- 239000007821 HATU Substances 0.000 claims 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N N,N′-Dicyclohexylcarbodiimide Substances C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000000477 aza group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53284203P | 2003-12-23 | 2003-12-23 | |
| PCT/US2004/042710 WO2005062828A2 (en) | 2003-12-23 | 2004-12-20 | New compounds useful as metal chelators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007516288A JP2007516288A (ja) | 2007-06-21 |
| JP2007516288A5 true JP2007516288A5 (enExample) | 2007-12-06 |
Family
ID=34738842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547204A Withdrawn JP2007516288A (ja) | 2003-12-23 | 2004-12-20 | 金属キレート剤として有用な新規化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080124270A1 (enExample) |
| EP (1) | EP1699466A4 (enExample) |
| JP (1) | JP2007516288A (enExample) |
| WO (1) | WO2005062828A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1812453A1 (en) * | 2004-10-20 | 2007-08-01 | Therapharm GmbH | Method of preparing or synthesizing polyazamacrocycle derivatives |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| JPWO2008108163A1 (ja) * | 2007-03-06 | 2010-06-10 | コニカミノルタホールディングス株式会社 | ガドリニウム化合物及びｍｒｉ用造影剤 |
| WO2008134289A2 (en) * | 2007-04-26 | 2008-11-06 | Mallinckrodt Inc. | High relaxivity coordinatively unsaturated lanthanide complexes |
| EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| KR101253100B1 (ko) * | 2010-02-16 | 2013-04-10 | 경북대학교 산학협력단 | 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용 |
| CZ307488B6 (cs) * | 2015-11-20 | 2018-10-10 | Univerzita Karlova V Praze | Sloučeniny na bázi cyklamu, jejich konjugáty, cílicí konjugáty, koordinační sloučeniny, farmaceutický přípravek je obsahující, způsob jejich přípravy a jejich použití |
| WO2017137477A1 (en) | 2016-02-09 | 2017-08-17 | Bracco Suisse Sa | A recombinant chimeric protein for selectins targeting |
| KR101725983B1 (ko) * | 2016-02-17 | 2017-04-11 | 경북대학교 산학협력단 | 트리-터셔리-부틸-2,2`,2``-(1,4,7,10-테트라아자사이클로도데칸-1,4,7-트리일)트리아세테이트의 신규한 제조방법 |
| US11007283B2 (en) | 2016-04-13 | 2021-05-18 | Bracco Imaging S.P.A. | Contrast agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693190B1 (en) * | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
| IT1297035B1 (it) * | 1997-12-30 | 1999-08-03 | Bracco Spa | Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico |
| EP1170021A2 (de) * | 2000-05-15 | 2002-01-09 | Shering Aktiengesellschaft | Konjugate von Peptiden und Lanthanid-Chelaten für die Fluoreszenzdiagnostik |
| EP1429783A4 (en) * | 2001-09-04 | 2006-08-09 | Univ Texas Tech | VERSATILE CHELTS FOR MULTIMODAL PICTURE SETTING |
-
2004
- 2004-12-20 JP JP2006547204A patent/JP2007516288A/ja not_active Withdrawn
- 2004-12-20 WO PCT/US2004/042710 patent/WO2005062828A2/en not_active Ceased
- 2004-12-20 EP EP04814846A patent/EP1699466A4/en not_active Withdrawn
- 2004-12-20 US US10/584,430 patent/US20080124270A1/en not_active Abandoned
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