JP2024512612A5 - - Google Patents

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Publication number
JP2024512612A5
JP2024512612A5 JP2023558983A JP2023558983A JP2024512612A5 JP 2024512612 A5 JP2024512612 A5 JP 2024512612A5 JP 2023558983 A JP2023558983 A JP 2023558983A JP 2023558983 A JP2023558983 A JP 2023558983A JP 2024512612 A5 JP2024512612 A5 JP 2024512612A5
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JP
Japan
Prior art keywords
item
nucleotides
length
sense strand
molecule described
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023558983A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024512612A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/021789 external-priority patent/WO2022204429A1/en
Publication of JP2024512612A publication Critical patent/JP2024512612A/ja
Publication of JP2024512612A5 publication Critical patent/JP2024512612A5/ja
Pending legal-status Critical Current

Links

JP2023558983A 2021-03-24 2022-03-24 二本鎖ｓｉＲＮＡを使用したミクログリア遺伝子サイレンシング Pending JP2024512612A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163165518P 2021-03-24 2021-03-24
US63/165,518 2021-03-24
PCT/US2022/021789 WO2022204429A1 (en) 2021-03-24 2022-03-24 Microglial gene silencing using double-stranded sirna

Publications (2)

Publication Number Publication Date
JP2024512612A JP2024512612A (ja) 2024-03-19
JP2024512612A5 true JP2024512612A5 (https=) 2025-04-01

Family

ID=83397877

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023558983A Pending JP2024512612A (ja) 2021-03-24 2022-03-24 二本鎖ｓｉＲＮＡを使用したミクログリア遺伝子サイレンシング

Country Status (7)

Country Link
US (1) US20240200063A1 (https=)
EP (1) EP4313070A4 (https=)
JP (1) JP2024512612A (https=)
CN (1) CN117835986A (https=)
AU (1) AU2022246147A1 (https=)
CA (1) CA3214657A1 (https=)
WO (1) WO2022204429A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118374495A (zh) * 2024-03-28 2024-07-23 深圳脑健生物技术有限公司 一种抑制NLRP3基因表达的siRNA及其前体和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2556272T3 (es) * 2004-11-18 2016-01-14 The Board Of Trustees Of The University Of Illinois Constructos de ARNsi multicistrónico para inhibir tumores
PL3277814T3 (pl) * 2015-04-03 2020-11-30 University Of Massachusetts Związki oligonukleotydowe ukierunkowane na mrna huntingtyny
US10478503B2 (en) * 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
JP2022528487A (ja) * 2019-03-29 2022-06-13 ユニバーシティ・オブ・マサチューセッツ Ｃ９ｏｒｆ７２のオリゴヌクレオチドベースの調節
WO2021026490A1 (en) * 2019-08-08 2021-02-11 Mpeg La, L.L.C. Cns targeting with multimeric oligonucleotides
KR20220047989A (ko) * 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드

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