JP2024511473A5 - - Google Patents
Info
- Publication number
- JP2024511473A5 JP2024511473A5 JP2023558979A JP2023558979A JP2024511473A5 JP 2024511473 A5 JP2024511473 A5 JP 2024511473A5 JP 2023558979 A JP2023558979 A JP 2023558979A JP 2023558979 A JP2023558979 A JP 2023558979A JP 2024511473 A5 JP2024511473 A5 JP 2024511473A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- formula
- sirna molecule
- ribonucleoside
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163165543P | 2021-03-24 | 2021-03-24 | |
| US63/165,543 | 2021-03-24 | ||
| PCT/US2022/021790 WO2022204430A1 (en) | 2021-03-24 | 2022-03-24 | Double-stranded sirna having patterned chemical modifications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024511473A JP2024511473A (ja) | 2024-03-13 |
| JP2024511473A5 true JP2024511473A5 (https=) | 2025-04-01 |
Family
ID=83397880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023558979A Pending JP2024511473A (ja) | 2021-03-24 | 2022-03-24 | パターン化化学修飾を有する二本鎖ｓｉｒｎａ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240182892A1 (https=) |
| EP (1) | EP4313075A4 (https=) |
| JP (1) | JP2024511473A (https=) |
| CN (1) | CN117597133A (https=) |
| AU (1) | AU2022242899A1 (https=) |
| CA (1) | CA3214660A1 (https=) |
| WO (1) | WO2022204430A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2023354001A1 (en) * | 2022-09-28 | 2025-04-17 | Atalanta Therapeutics, Inc. | Compositions and methods for treatment of huntington's disease |
| WO2024169770A1 (zh) * | 2023-02-17 | 2024-08-22 | 苏州时安生物技术有限公司 | 一种抑制SCN9A基因表达的siRNA、其药物组合物及用途 |
| US20250145992A1 (en) * | 2023-10-18 | 2025-05-08 | University Of Massachusetts | Oligonucleotides with ethylene glycol modification |
| WO2025108284A1 (en) * | 2023-11-20 | 2025-05-30 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of sodium voltage-gated channel alpha subunit 9 (scn9a) |
| US12553050B2 (en) | 2024-03-22 | 2026-02-17 | Takeda Pharmaceutical Company Limited | Compositions and methods for inhibiting cytochrome P450 family 7 subfamily a member 1 (CYP7A1) expression |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9181551B2 (en) * | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| IL292159B1 (en) * | 2012-12-05 | 2026-04-01 | Alnylam Pharmaceuticals Inc | PCSK9 iRNA compositions and methods of using them |
| US20160319278A1 (en) * | 2015-04-03 | 2016-11-03 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| CN115927335A (zh) * | 2015-04-13 | 2023-04-07 | 阿尔尼拉姆医药品有限公司 | 类血管生成素3（ANGPTL3）iRNA组合物及其使用方法 |
| PT3329002T (pt) * | 2015-07-31 | 2021-01-12 | Alnylam Pharmaceuticals Inc | Composições de iarn de transtirretina (ttr) e métodos de seu uso para tratamento ou prevenção de doenças associadas à ttr |
| DK3607069T3 (da) * | 2017-04-05 | 2022-11-21 | Silence Therapeutics Gmbh | Produkter og sammensætninger |
| JP7406793B2 (ja) * | 2017-06-23 | 2023-12-28 | ユニバーシティー オブ マサチューセッツ | ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法 |
| CN111527206A (zh) * | 2017-11-13 | 2020-08-11 | 赛伦斯治疗有限责任公司 | 用于抑制靶标基因表达的包含二硫代磷酸酯键的核酸 |
| CN113811311A (zh) * | 2019-03-15 | 2021-12-17 | 马萨诸塞大学 | 用于组织特异性apoe调节的寡核苷酸 |
| JP2022528487A (ja) * | 2019-03-29 | 2022-06-13 | ユニバーシティ・オブ・マサチューセッツ | Ｃ９ｏｒｆ７２のオリゴヌクレオチドベースの調節 |
| WO2021041247A1 (en) * | 2019-08-23 | 2021-03-04 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
-
2022
- 2022-03-24 WO PCT/US2022/021790 patent/WO2022204430A1/en not_active Ceased
- 2022-03-24 CA CA3214660A patent/CA3214660A1/en active Pending
- 2022-03-24 EP EP22776673.0A patent/EP4313075A4/en active Pending
- 2022-03-24 US US18/283,666 patent/US20240182892A1/en active Pending
- 2022-03-24 JP JP2023558979A patent/JP2024511473A/ja active Pending
- 2022-03-24 CN CN202280037397.4A patent/CN117597133A/zh active Pending
- 2022-03-24 AU AU2022242899A patent/AU2022242899A1/en active Pending
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