CN117835986A - 使用双链siRNA进行小胶质基因沉默 - Google Patents

使用双链siRNA进行小胶质基因沉默 Download PDF

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Publication number
CN117835986A
CN117835986A CN202280036538.0A CN202280036538A CN117835986A CN 117835986 A CN117835986 A CN 117835986A CN 202280036538 A CN202280036538 A CN 202280036538A CN 117835986 A CN117835986 A CN 117835986A
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nucleotides
length
gene
sense strand
antisense strand
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CN202280036538.0A
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English (en)
Chinese (zh)
Inventor
D·库蒂斯
A·杰克逊
B·安德昂
B·戈丁霍
陈庆敏
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Atalanta Treatment Co
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Atalanta Treatment Co
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN202280036538.0A 2021-03-24 2022-03-24 使用双链siRNA进行小胶质基因沉默 Pending CN117835986A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163165518P 2021-03-24 2021-03-24
US63/165,518 2021-03-24
PCT/US2022/021789 WO2022204429A1 (en) 2021-03-24 2022-03-24 Microglial gene silencing using double-stranded sirna

Publications (1)

Publication Number Publication Date
CN117835986A true CN117835986A (zh) 2024-04-05

Family

ID=83397877

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280036538.0A Pending CN117835986A (zh) 2021-03-24 2022-03-24 使用双链siRNA进行小胶质基因沉默

Country Status (7)

Country Link
US (1) US20240200063A1 (https=)
EP (1) EP4313070A4 (https=)
JP (1) JP2024512612A (https=)
CN (1) CN117835986A (https=)
AU (1) AU2022246147A1 (https=)
CA (1) CA3214657A1 (https=)
WO (1) WO2022204429A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118374495A (zh) * 2024-03-28 2024-07-23 深圳脑健生物技术有限公司 一种抑制NLRP3基因表达的siRNA及其前体和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006055727A2 (en) * 2004-11-18 2006-05-26 The Board Of Trustees Of The University Of Illinois MULTICISTRONIC siRNA CONSTRUCTS TO INHIBIT TUMORS
SMT202000454T1 (it) * 2015-04-03 2020-11-10 Univ Massachusetts Cmposti oligonucleotidici per bersagliare l'mrn della huntingtina
WO2017132669A1 (en) * 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
US20200385737A1 (en) * 2019-03-29 2020-12-10 University Of Massachusetts OLIGONUCLEOTIDE-BASED MODULATION OF C9orf72
WO2021026490A1 (en) * 2019-08-08 2021-02-11 Mpeg La, L.L.C. Cns targeting with multimeric oligonucleotides
MX2022001710A (es) * 2019-08-09 2022-05-10 Univ Massachusetts Oligonucleótidos modificados químicamente dirigidos a los snp.

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Publication number Publication date
CA3214657A1 (en) 2022-09-29
EP4313070A1 (en) 2024-02-07
AU2022246147A1 (en) 2023-11-09
US20240200063A1 (en) 2024-06-20
EP4313070A4 (en) 2025-06-11
WO2022204429A1 (en) 2022-09-29
JP2024512612A (ja) 2024-03-19

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