JP2024510526A5 - - Google Patents
Info
- Publication number
- JP2024510526A5 JP2024510526A5 JP2023559011A JP2023559011A JP2024510526A5 JP 2024510526 A5 JP2024510526 A5 JP 2024510526A5 JP 2023559011 A JP2023559011 A JP 2023559011A JP 2023559011 A JP2023559011 A JP 2023559011A JP 2024510526 A5 JP2024510526 A5 JP 2024510526A5
- Authority
- JP
- Japan
- Prior art keywords
- cysteine
- domain
- positions
- antibody construct
- cysteine residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163166450P | 2021-03-26 | 2021-03-26 | |
| US63/166,450 | 2021-03-26 | ||
| PCT/CA2022/050453 WO2022198335A1 (en) | 2021-03-26 | 2022-03-25 | Cysteine engineered antibody constructs, conjugates and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024510526A JP2024510526A (ja) | 2024-03-07 |
| JP2024510526A5 true JP2024510526A5 (https=) | 2025-04-03 |
Family
ID=83395224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023559011A Pending JP2024510526A (ja) | 2021-03-26 | 2022-03-25 | システイン操作された抗体コンストラクト、コンジュゲート、及び使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20260042847A1 (https=) |
| EP (1) | EP4314043A4 (https=) |
| JP (1) | JP2024510526A (https=) |
| KR (1) | KR20230171944A (https=) |
| CN (1) | CN117242091A (https=) |
| AU (1) | AU2022243931A1 (https=) |
| BR (1) | BR112023019698A2 (https=) |
| CA (1) | CA3178093A1 (https=) |
| IL (1) | IL307231A (https=) |
| MX (1) | MX2023011316A (https=) |
| WO (1) | WO2022198335A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3264074A1 (en) * | 2022-09-28 | 2024-04-04 | Zymeworks Bc Inc. | C-MET TARGETED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE |
| WO2024227427A1 (en) * | 2023-04-29 | 2024-11-07 | Innovent Biologics (Suzhou) Co., Ltd. | Modified antibodies, antibody fragments thereof, and antibody-drug conjugates |
| EP4548936A1 (en) * | 2023-10-30 | 2025-05-07 | BioNTech SE | Antibody-drug conjugates having a tailor-made drug-to-antibody ratio |
| EP4706676A1 (en) * | 2024-09-10 | 2026-03-11 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Cysteine-engineered antigen-binding domains |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6685924B2 (ja) * | 2014-04-11 | 2020-04-22 | メディミューン，エルエルシー | システイン操作抗体を含むコンジュゲート化合物 |
| EP2982692A1 (en) * | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| US11419944B2 (en) * | 2016-10-11 | 2022-08-23 | Byondis B.V. | Non-linear self-immolative linkers and conjugates thereof |
| AU2018288030B2 (en) * | 2017-06-20 | 2022-02-03 | Systimmune, Inc. | Screening of fixed-point coupling sites of cysteine-modified antibody-toxin conjugate (TDC) |
| CN111434687B (zh) * | 2019-01-15 | 2022-03-11 | 南京赛新生物科技有限公司 | 一种抗体及其应用 |
| KR20220148235A (ko) * | 2020-02-28 | 2022-11-04 | 젠자임 코포레이션 | 최적화된 약물 접합을 위한 변형된 결합 폴리펩티드 |
-
2022
- 2022-03-25 KR KR1020237036900A patent/KR20230171944A/ko active Pending
- 2022-03-25 WO PCT/CA2022/050453 patent/WO2022198335A1/en not_active Ceased
- 2022-03-25 BR BR112023019698A patent/BR112023019698A2/pt unknown
- 2022-03-25 US US18/551,851 patent/US20260042847A1/en active Pending
- 2022-03-25 MX MX2023011316A patent/MX2023011316A/es unknown
- 2022-03-25 CA CA3178093A patent/CA3178093A1/en active Pending
- 2022-03-25 EP EP22773856.4A patent/EP4314043A4/en active Pending
- 2022-03-25 IL IL307231A patent/IL307231A/en unknown
- 2022-03-25 CN CN202280025143.0A patent/CN117242091A/zh active Pending
- 2022-03-25 JP JP2023559011A patent/JP2024510526A/ja active Pending
- 2022-03-25 AU AU2022243931A patent/AU2022243931A1/en active Pending
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