JP2024510501A - インドシアニングリーンの安定な処方物 - Google Patents

インドシアニングリーンの安定な処方物 Download PDF

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Publication number
JP2024510501A
JP2024510501A JP2023557349A JP2023557349A JP2024510501A JP 2024510501 A JP2024510501 A JP 2024510501A JP 2023557349 A JP2023557349 A JP 2023557349A JP 2023557349 A JP2023557349 A JP 2023557349A JP 2024510501 A JP2024510501 A JP 2024510501A
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JP
Japan
Prior art keywords
indocyanine green
composition
histidine
icg
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023557349A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024510501A5 (enExample
Inventor
ローラン・マリナ
サヤ・ババ
クリヴォ・フロリアン
ロペ・ニコラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Provepharm Life Solutions SA
Original Assignee
Provepharm Life Solutions SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provepharm Life Solutions SA filed Critical Provepharm Life Solutions SA
Publication of JP2024510501A publication Critical patent/JP2024510501A/ja
Publication of JP2024510501A5 publication Critical patent/JP2024510501A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023557349A 2021-03-17 2022-03-14 インドシアニングリーンの安定な処方物 Pending JP2024510501A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21305324.2 2021-03-17
EP21305324 2021-03-17
PCT/EP2022/056446 WO2022194734A1 (en) 2021-03-17 2022-03-14 Stable formulations of indocyanine green

Publications (2)

Publication Number Publication Date
JP2024510501A true JP2024510501A (ja) 2024-03-07
JP2024510501A5 JP2024510501A5 (enExample) 2025-02-26

Family

ID=75302476

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023557349A Pending JP2024510501A (ja) 2021-03-17 2022-03-14 インドシアニングリーンの安定な処方物

Country Status (7)

Country Link
US (1) US20240156991A1 (enExample)
EP (1) EP4308076B1 (enExample)
JP (1) JP2024510501A (enExample)
CN (1) CN117098532A (enExample)
BR (1) BR112023018929A2 (enExample)
ES (1) ES3042376T3 (enExample)
WO (1) WO2022194734A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024510500A (ja) * 2021-03-17 2024-03-07 プルーヴファーム・ライフ・ソリューションズ インドシアニングリーンの安定な処方物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08509260A (ja) * 1993-04-20 1996-10-01 マリンクロット・メディカル・インコーポレイテッド 電圧感受性染料の安定化
FR2710060B1 (fr) 1993-09-17 1995-11-17 Rech Biolog Et Procédé de préparation de benz[e]indoles substitués de pureté élevée et leurs sels alcalins.
US6944493B2 (en) * 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
CA2635975A1 (en) * 2006-01-04 2007-07-12 Do-Coop Technologies Ltd. Compositions and methods for enhancing in-vivo uptake of pharmaceutical agents
DE102007030403A1 (de) 2007-06-29 2009-01-08 Universität Bielefeld Verfahren zur Verbesserung der Photostabilität von Fluoreszenzfarbstoffen
CN103301482B (zh) 2013-06-27 2014-12-17 深圳先进技术研究院 两亲性三嵌段聚多肽载icg胶束及其制备方法
JP6623479B2 (ja) 2015-02-08 2019-12-25 トンリ・バイオメディカル・カンパニー・リミテッド 脂質ナノ粒子及びその使用
CA3021809A1 (en) * 2015-05-11 2016-11-17 Dicronis Sagl Compositions for circulatory system visualization
DK3383436T3 (da) 2015-12-01 2023-11-20 Dishman Carbogen Amcis Ltd Forbedret fremgangsmåde til fremstilling af indocyaningrønt
US20190337896A1 (en) 2018-05-02 2019-11-07 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF SODIUM 4-(2-((1E,3E,5E,7Z)-7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO[e]INDOL-2(3H)-YLIDENE) HEPTA-1,3,5-TRIENYL)-1,1-DIMETHYL-1H-BENZO[e]INDOLIUM-3-YL) BUTANE-1-SULFONATE (INDOCYANINE GREEN)
WO2020240514A1 (en) 2019-05-30 2020-12-03 Leiutis Pharmaceuticals Pvt, Ltd. Stable formulations of indocyanine green

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRITISH JOURNAL OF CANCER, vol. Vol. 80, No. 3/4, JPN6025050226, 1999, pages 360 - 363, ISSN: 0005749321 *
LETTERS IN APPLIED MICROBIOLOGY, vol. 62, JPN6025050225, 2015, pages 230 - 236, ISSN: 0005749320 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024510500A (ja) * 2021-03-17 2024-03-07 プルーヴファーム・ライフ・ソリューションズ インドシアニングリーンの安定な処方物

Also Published As

Publication number Publication date
EP4308076A1 (en) 2024-01-24
EP4308076B1 (en) 2025-07-16
CN117098532A (zh) 2023-11-21
BR112023018929A2 (pt) 2023-10-10
ES3042376T3 (en) 2025-11-20
WO2022194734A1 (en) 2022-09-22
US20240156991A1 (en) 2024-05-16

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