BR112023018929A2 - Formulações estáveis de indocianina verde - Google Patents

Formulações estáveis de indocianina verde

Info

Publication number
BR112023018929A2
BR112023018929A2 BR112023018929A BR112023018929A BR112023018929A2 BR 112023018929 A2 BR112023018929 A2 BR 112023018929A2 BR 112023018929 A BR112023018929 A BR 112023018929A BR 112023018929 A BR112023018929 A BR 112023018929A BR 112023018929 A2 BR112023018929 A2 BR 112023018929A2
Authority
BR
Brazil
Prior art keywords
indocyanine green
stable
formulations
green formulations
compositions
Prior art date
Application number
BR112023018929A
Other languages
English (en)
Inventor
Babak Sayah
Florian Courivaud
Marina Laurent
Nicolas Lopez
Original Assignee
Provepharm Life Solutions
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provepharm Life Solutions filed Critical Provepharm Life Solutions
Publication of BR112023018929A2 publication Critical patent/BR112023018929A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)

Abstract

formulações estáveis de indocianina verde. a invenção se refere a composições de indocianina verde com estabilidade melhorada, especialmente estabilidade de armazenamento melhorada. em particular, a invenção se refere a composições de icg compreendendo indocianina verde e histidina.
BR112023018929A 2021-03-17 2022-03-14 Formulações estáveis de indocianina verde BR112023018929A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21305324 2021-03-17
PCT/EP2022/056446 WO2022194734A1 (en) 2021-03-17 2022-03-14 Stable formulations of indocyanine green

Publications (1)

Publication Number Publication Date
BR112023018929A2 true BR112023018929A2 (pt) 2023-10-10

Family

ID=75302476

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023018929A BR112023018929A2 (pt) 2021-03-17 2022-03-14 Formulações estáveis de indocianina verde

Country Status (6)

Country Link
US (1) US20240156991A1 (pt)
EP (1) EP4308076A1 (pt)
JP (1) JP2024510501A (pt)
CN (1) CN117098532A (pt)
BR (1) BR112023018929A2 (pt)
WO (1) WO2022194734A1 (pt)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08509260A (ja) * 1993-04-20 1996-10-01 マリンクロット・メディカル・インコーポレイテッド 電圧感受性染料の安定化
FR2710060B1 (fr) 1993-09-17 1995-11-17 Rech Biolog Et Procédé de préparation de benz[e]indoles substitués de pureté élevée et leurs sels alcalins.
US6944493B2 (en) 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
DE102007030403A1 (de) 2007-06-29 2009-01-08 Universität Bielefeld Verfahren zur Verbesserung der Photostabilität von Fluoreszenzfarbstoffen
CN103301482B (zh) 2013-06-27 2014-12-17 深圳先进技术研究院 两亲性三嵌段聚多肽载icg胶束及其制备方法
WO2016123864A1 (en) 2015-02-08 2016-08-11 Tongli Biomedical Co., Ltd. Lipid nanoparticles and uses thereof
US10287436B2 (en) 2015-12-01 2019-05-14 Dishman Carbogen Amcis Limited Process for the preparation of indocyanine green
US20190337896A1 (en) 2018-05-02 2019-11-07 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF SODIUM 4-(2-((1E,3E,5E,7Z)-7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO[e]INDOL-2(3H)-YLIDENE) HEPTA-1,3,5-TRIENYL)-1,1-DIMETHYL-1H-BENZO[e]INDOLIUM-3-YL) BUTANE-1-SULFONATE (INDOCYANINE GREEN)
WO2020240514A1 (en) 2019-05-30 2020-12-03 Leiutis Pharmaceuticals Pvt, Ltd. Stable formulations of indocyanine green

Also Published As

Publication number Publication date
EP4308076A1 (en) 2024-01-24
US20240156991A1 (en) 2024-05-16
CN117098532A (zh) 2023-11-21
WO2022194734A1 (en) 2022-09-22
JP2024510501A (ja) 2024-03-07

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