JP2024509920A - Ｅｇｆｒ活性化変異を欠くがんの治療 - Google Patents

Ｅｇｆｒ活性化変異を欠くがんの治療 Download PDF

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JP2024509920A
JP2024509920A JP2023555245A JP2023555245A JP2024509920A JP 2024509920 A JP2024509920 A JP 2024509920A JP 2023555245 A JP2023555245 A JP 2023555245A JP 2023555245 A JP2023555245 A JP 2023555245A JP 2024509920 A JP2024509920 A JP 2024509920A
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egfr
cancer
seq
met
bispecific anti
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JP2024509920A5 (cg-RX-API-DMAC10.html
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ジェイ． ヘンリー，ベンジャミン
エル． ムーアズ，シェリ
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ヤンセン バイオテツク，インコーポレーテツド
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2023555245A 2021-03-09 2022-03-07 Ｅｇｆｒ活性化変異を欠くがんの治療 Pending JP2024509920A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163158552P 2021-03-09 2021-03-09
US63/158,552 2021-03-09
PCT/IB2022/052009 WO2022189942A1 (en) 2021-03-09 2022-03-07 Treatment of cancers lacking egfr-activating mutations

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JP2024509920A true JP2024509920A (ja) 2024-03-05
JP2024509920A5 JP2024509920A5 (cg-RX-API-DMAC10.html) 2025-03-13

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US (1) US20220298248A1 (cg-RX-API-DMAC10.html)
EP (1) EP4304644A1 (cg-RX-API-DMAC10.html)
JP (1) JP2024509920A (cg-RX-API-DMAC10.html)
KR (1) KR20230156094A (cg-RX-API-DMAC10.html)
CN (1) CN116997358A (cg-RX-API-DMAC10.html)
AU (1) AU2022233518A1 (cg-RX-API-DMAC10.html)
BR (1) BR112023018278A2 (cg-RX-API-DMAC10.html)
CA (1) CA3212669A1 (cg-RX-API-DMAC10.html)
CL (2) CL2023002663A1 (cg-RX-API-DMAC10.html)
IL (1) IL305700A (cg-RX-API-DMAC10.html)
JO (1) JOP20230211A1 (cg-RX-API-DMAC10.html)
MX (1) MX2023010633A (cg-RX-API-DMAC10.html)
WO (1) WO2022189942A1 (cg-RX-API-DMAC10.html)

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Publication number Priority date Publication date Assignee Title
EP4204455A4 (en) 2020-08-25 2024-10-16 Janssen Biotech, Inc. Treatment of non-small cell lung cancer with egfr mutations

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JP2016505537A (ja) * 2012-11-21 2016-02-25 ヤンセン バイオテツク，インコーポレーテツド 二重特異性ＥＧＦＲ／ｃ−Ｍｅｔ抗体

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CL2024001201A1 (es) 2024-10-25
BR112023018278A2 (pt) 2023-10-31
CN116997358A (zh) 2023-11-03
AU2022233518A1 (en) 2023-10-26
CL2023002663A1 (es) 2024-02-02
CA3212669A1 (en) 2022-09-15
US20220298248A1 (en) 2022-09-22
KR20230156094A (ko) 2023-11-13
IL305700A (en) 2023-11-01
EP4304644A1 (en) 2024-01-17
MX2023010633A (es) 2023-11-28
JOP20230211A1 (ar) 2023-09-07
WO2022189942A1 (en) 2022-09-15

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