JP2024509760A - Ａｐｏｌ１阻害剤及び使用方法 - Google Patents

Ａｐｏｌ１阻害剤及び使用方法 Download PDF

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JP2024509760A
JP2024509760A JP2023550044A JP2023550044A JP2024509760A JP 2024509760 A JP2024509760 A JP 2024509760A JP 2023550044 A JP2023550044 A JP 2023550044A JP 2023550044 A JP2023550044 A JP 2023550044A JP 2024509760 A JP2024509760 A JP 2024509760A
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pharmaceutically acceptable
tautomer
stereoisomer
acceptable salt
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JP2024509760A5 (https=
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パトリック サン テ リー，
トッド ジョナサン オーガスト ユーイング，
アダム ニール リード，
クリストファー ジョセフ シンズ，
ビロン ジャン，
サラ エム． ブロナー，
ジュニア， デイビッド ジョン モーガンズ
マールテン フック，
ビクトリア アン アシモン，
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メイズ セラピューティクス， インコーポレイテッド
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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JPH05505797A (ja) * 1990-03-09 1993-08-26 ブリテイッシュ・テクノロジー・グループ・リミテッド 抗不整脈剤
US20200377479A1 (en) * 2018-12-17 2020-12-03 Vertex Pharmacéuticals Incorporated Inhibitors of apol1 and methods of using same

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KR20010000196A (ko) * 2000-08-10 2001-01-05 하현준 아지리딘으로부터 페닐알라닌 및 호모페닐알라닌을포함하는 알파아미노산 및 그 유도체의 제조방법
US20040024024A1 (en) 2001-05-11 2004-02-05 Freskos John N. Aromatic sulfone hydroxamates and their use as protease inhibitors

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JPH05505797A (ja) * 1990-03-09 1993-08-26 ブリテイッシュ・テクノロジー・グループ・リミテッド 抗不整脈剤
US20200377479A1 (en) * 2018-12-17 2020-12-03 Vertex Pharmacéuticals Incorporated Inhibitors of apol1 and methods of using same

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