AU2022224648A1 - Apol1 inhibitors and methods of use - Google Patents

Apol1 inhibitors and methods of use Download PDF

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Publication number
AU2022224648A1
AU2022224648A1 AU2022224648A AU2022224648A AU2022224648A1 AU 2022224648 A1 AU2022224648 A1 AU 2022224648A1 AU 2022224648 A AU2022224648 A AU 2022224648A AU 2022224648 A AU2022224648 A AU 2022224648A AU 2022224648 A1 AU2022224648 A1 AU 2022224648A1
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compound
pharmaceutically acceptable
foregoing
stereoisomer
tautomer
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Inventor
Victoria Anne ASSIMON
Sarah M. BRONNER
Todd Jonathan August EWING
Maarten HOEK
Patrick Sang Tae LEE
David John Morgans Jr.
Adam Neil REID
Christopher Joseph Sinz
Birong Zhang
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Maze Therapeutics Inc
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Maze Therapeutics Inc
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
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    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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