JP2024506909A - Ｈｐｋ１アンタゴニスト及びその使用 - Google Patents

Ｈｐｋ１アンタゴニスト及びその使用 Download PDF

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JP2024506909A
JP2024506909A JP2023548686A JP2023548686A JP2024506909A JP 2024506909 A JP2024506909 A JP 2024506909A JP 2023548686 A JP2023548686 A JP 2023548686A JP 2023548686 A JP2023548686 A JP 2023548686A JP 2024506909 A JP2024506909 A JP 2024506909A
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nitrogen
sulfur
oxygen
compound
independently selected
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JPWO2022174253A5 (https=
JP2024506909A5 (https=
Inventor
ニール カイラ，
イアン リニー，
スチュアート ウォード，
グラント ウィシャート，
ベンジャミン ウィッタカー，
ウィリアム シンコ，
ショーン ワッツ，
マーク アンソニー アッシュウェル，
バイロン スコット デラバール，
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ニンバス サターン， インコーポレイテッド
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Publication of JP2024506909A publication Critical patent/JP2024506909A/ja
Publication of JPWO2022174253A5 publication Critical patent/JPWO2022174253A5/ja
Publication of JP2024506909A5 publication Critical patent/JP2024506909A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2023548686A 2021-02-12 2022-02-11 Ｈｐｋ１アンタゴニスト及びその使用 Pending JP2024506909A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163148857P 2021-02-12 2021-02-12
US63/148,857 2021-02-12
PCT/US2022/070627 WO2022174253A1 (en) 2021-02-12 2022-02-11 Hpk1 antagonists and uses thereof

Publications (3)

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JP2024506909A true JP2024506909A (ja) 2024-02-15
JPWO2022174253A5 JPWO2022174253A5 (https=) 2025-02-18
JP2024506909A5 JP2024506909A5 (https=) 2025-02-18

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US (1) US12252488B2 (https=)
EP (1) EP4291235A4 (https=)
JP (1) JP2024506909A (https=)
CN (1) CN117120090A (https=)
WO (1) WO2022174253A1 (https=)

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TWI721623B (zh) 2018-10-31 2021-03-11 美商基利科學股份有限公司 經取代之6-氮雜苯并咪唑化合物
TW202136261A (zh) 2018-10-31 2021-10-01 美商基利科學股份有限公司 經取代之6-氮雜苯并咪唑化合物
US11453681B2 (en) 2019-05-23 2022-09-27 Gilead Sciences, Inc. Substituted eneoxindoles and uses thereof
CN116063329A (zh) * 2021-10-29 2023-05-05 北京望实智慧科技有限公司 Hpk1抑制剂、制备方法及其用途
WO2023193759A1 (en) * 2022-04-07 2023-10-12 Insilico Medicine Ip Limited Hpk1 antagonists and uses thereof
GB202216324D0 (en) * 2022-11-02 2022-12-14 Cerevance Ltd Novel compounds
WO2024140679A1 (en) * 2022-12-26 2024-07-04 Insilico Medicine Ip Limited Spirocyclic hpk1 antagonists and uses thereof
US11932649B1 (en) 2023-08-17 2024-03-19 King Faisal University 5-(3-substituted phenyl)-pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione derivatives as anticancer agents

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US12252488B2 (en) 2025-03-18
EP4291235A1 (en) 2023-12-20
US20230096641A1 (en) 2023-03-30
WO2022174253A1 (en) 2022-08-18
CN117120090A (zh) 2023-11-24

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