|
US5480974A
(en)
|
1993-06-18 |
1996-01-02 |
The Scripps Research Institute |
Antibodies to human C5a receptor
|
|
CA2463879C
(en)
|
2001-10-25 |
2012-12-04 |
Genentech, Inc. |
Glycoprotein compositions
|
|
US8071096B2
(en)
|
2002-01-25 |
2011-12-06 |
G2 Therapies Ltd |
Anti-C5aR antibodies and uses thereof
|
|
US8658773B2
(en)
|
2011-05-02 |
2014-02-25 |
Immunomedics, Inc. |
Ultrafiltration concentration of allotype selected antibodies for small-volume administration
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
EP1553975B8
(en)
|
2002-09-27 |
2023-04-12 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
WO2004043223A2
(en)
|
2002-11-05 |
2004-05-27 |
The Regents Of The University Of Michigan |
Compositions and methods for the diagnosis and treatment of sepsis
|
|
CA2512729C
(en)
|
2003-01-09 |
2014-09-16 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant fc regions and methods of using same
|
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
|
WO2004082568A2
(en)
|
2003-03-17 |
2004-09-30 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with complement component 5a receptor (c5ar)
|
|
AU2004266159A1
(en)
|
2003-08-22 |
2005-03-03 |
Biogen Idec Ma Inc. |
Improved antibodies having altered effector function and methods for making the same
|
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
|
US8399618B2
(en)
|
2004-10-21 |
2013-03-19 |
Xencor, Inc. |
Immunoglobulin insertions, deletions, and substitutions
|
|
WO2005050199A1
(en)
|
2003-10-31 |
2005-06-02 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with g protein- coupled receptor 77 (gpr77)
|
|
WO2005060739A1
(en)
|
2003-12-24 |
2005-07-07 |
G2 Inflammation Pty Ltd |
Transgenic non-human mammal comprising a polynucleotide encoding human or humanized c5ar
|
|
SI1706424T1
(sl)
|
2004-01-12 |
2010-01-29 |
Applied Molecular Evolution |
Variante fc regij
|
|
EP2471813B1
(en)
|
2004-07-15 |
2014-12-31 |
Xencor, Inc. |
Optimized Fc variants
|
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
|
US20100166741A1
(en)
*
|
2006-07-13 |
2010-07-01 |
Genentech , Inc. |
Altered br-3 binding polypeptides
|
|
JP2010501165A
(ja)
|
2006-08-22 |
2010-01-21 |
ジーツー インフラメイション プロプライエタリー リミテッド |
抗体の作製方法
|
|
ES2570153T3
(es)
|
2006-08-22 |
2016-05-17 |
Novo Nordisk As |
Anticuerpos anti-C5aR con propiedades mejoradas
|
|
WO2009005651A2
(en)
|
2007-06-29 |
2009-01-08 |
The Trustees Of The University Of Pennsylvania |
Complement-mediated thrombophilic assay
|
|
EP2229410A4
(en)
|
2007-12-05 |
2012-07-04 |
Massachusetts Inst Technology |
AGLYCOSYLATED IMMUNOGLOBULIN MUTANES
|
|
RU2010138612A
(ru)
*
|
2008-02-20 |
2012-03-27 |
Джи2 ИНФЛЕММЕЙШН ПТИ ЛТД (AU) |
ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ C5аR
|
|
US8940299B2
(en)
|
2008-02-28 |
2015-01-27 |
Case Western Reserve University |
Method of treating cancer
|
|
US20180256646A1
(en)
|
2008-03-06 |
2018-09-13 |
Case Western Reserve University |
Compositions and methods for modulating toll like receptor signal
|
|
CA2766565A1
(en)
|
2009-06-23 |
2010-12-29 |
Alexion Pharmaceuticals, Inc. |
Bispecific antibodies that bind to complement proteins
|
|
JP5898082B2
(ja)
|
2009-10-07 |
2016-04-06 |
マクロジェニクス,インコーポレーテッド |
フコシル化程度の変更により改良されたエフェクター機能を示すFc領域含有ポリペプチドおよびその使用法
|
|
EP2327725A1
(en)
|
2009-11-26 |
2011-06-01 |
InflaRx GmbH |
Anti-C5a binding moieties with high blocking activity
|
|
US8961967B2
(en)
|
2009-11-30 |
2015-02-24 |
Janssen Biotech, Inc. |
Antibody Fc mutants with ablated effector functions
|
|
US10053513B2
(en)
|
2009-11-30 |
2018-08-21 |
Janssen Biotech, Inc. |
Antibody Fc mutants with ablated effector functions
|
|
WO2011100477A2
(en)
|
2010-02-10 |
2011-08-18 |
Taiga Biotechnologies, Inc. |
Antibodies and processes for preparing the same
|
|
TWI667257B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
EP2647706B1
(en)
|
2010-11-30 |
2023-05-17 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
|
|
US11130801B2
(en)
|
2011-01-13 |
2021-09-28 |
Case Western Reserve University |
Method for inhibiting platelet derived growth factor signaling with C3aR or C5aR antibodies
|
|
US8952132B2
(en)
|
2011-02-07 |
2015-02-10 |
Research Development Foundation |
Engineered immunoglobulin FC polypeptides
|
|
MX352889B
(es)
|
2011-02-25 |
2017-12-13 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo de fc especifico para fcyriib.
|
|
TWI743461B
(zh)
|
2011-03-28 |
2021-10-21 |
法商賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
|
ES2692268T5
(en)
|
2011-03-29 |
2025-02-26 |
Roche Glycart Ag |
Antibody fc variants
|
|
AU2012233313C1
(en)
|
2011-03-30 |
2017-08-03 |
Chugai Seiyaku Kabushiki Kaisha |
Method for altering plasma retention and immunogenicity of antigen-binding molecule
|
|
DK3424953T3
(en)
|
2011-06-06 |
2020-11-02 |
Novo Nordisk As |
Terapeutiske antistoffer
|
|
TWI687439B
(zh)
|
2011-06-30 |
2020-03-11 |
中外製藥股份有限公司 |
異源二聚化多胜肽
|
|
JP6454547B2
(ja)
|
2011-07-06 |
2019-01-16 |
ゲンマブ エー/エス |
抗体重鎖のc末端の修飾による補体依存性細胞傷害の調節
|
|
SG11201404751UA
(en)
|
2012-02-09 |
2014-09-26 |
Chugai Pharmaceutical Co Ltd |
Modified fc region of antibody
|
|
US10011660B2
(en)
|
2012-04-30 |
2018-07-03 |
Medimmune, Llc |
Molecules with reduced effector function and extended half-lives, compositions, and uses thereof
|
|
JP6628966B2
(ja)
|
2012-06-14 |
2020-01-15 |
中外製薬株式会社 |
改変されたFc領域を含む抗原結合分子
|
|
CN104736174B
(zh)
|
2012-07-06 |
2019-06-14 |
根马布私人有限公司 |
具有三重突变的二聚体蛋白质
|
|
AU2013289883B2
(en)
|
2012-07-13 |
2018-11-01 |
Zymeworks Bc Inc. |
Bispecific asymmetric heterodimers comprising anti-CD3 constructs
|
|
SG10201709559PA
(en)
|
2012-08-24 |
2017-12-28 |
Chugai Pharmaceutical Co Ltd |
Fcγriib-specific fc region variant
|
|
US9790268B2
(en)
|
2012-09-12 |
2017-10-17 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
|
WO2014177459A2
(en)
|
2013-04-29 |
2014-11-06 |
F. Hoffmann-La Roche Ag |
Fc-receptor binding modified asymmetric antibodies and methods of use
|
|
JP2016523829A
(ja)
|
2013-05-08 |
2016-08-12 |
ノヴォ ノルディスク アー/エス |
C5arアンタゴニストの使用
|
|
KR102332303B1
(ko)
|
2013-05-31 |
2021-11-26 |
자임워크스 인코포레이티드 |
감소되거나 침묵화된 효과기 기능을 갖는 이종다량체
|
|
SI3011345T1
(sl)
|
2013-08-07 |
2017-12-29 |
Alexion Pharmaceuticals, Inc. |
Biomarkerski proteini za atipični hemolitični uremični sindrom (ahus)
|
|
JP6668345B2
(ja)
|
2014-11-21 |
2020-03-18 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
修飾された重鎖定常領域を含む抗体
|
|
KR101860280B1
(ko)
|
2014-12-19 |
2018-05-21 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
|
|
US10526408B2
(en)
|
2015-08-28 |
2020-01-07 |
Research Development Foundation |
Engineered antibody FC variants
|
|
US20180243370A1
(en)
|
2015-09-14 |
2018-08-30 |
Children's Hospital Medical Center |
Methods and compositions for treatment of gaucher disease via modulation of c5a receptor
|
|
CN106957366B
(zh)
|
2016-01-12 |
2022-02-01 |
上海昀怡健康科技发展有限公司 |
一种C5aR抗体及其制备方法和应用
|
|
HRP20260151T1
(hr)
|
2016-08-02 |
2026-03-27 |
Visterra, Inc. |
Modificirani polipeptidi i njihova uporaba
|
|
KR20190057083A
(ko)
|
2016-10-06 |
2019-05-27 |
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 |
공정 불순물에 대한 결합이 감소된 항체
|
|
FR3058159B1
(fr)
|
2016-10-28 |
2022-02-25 |
Lab Francais Du Fractionnement |
Variants de polypeptide fc presentant une demi-vie augmentee
|
|
EP3576793A4
(en)
|
2017-02-06 |
2021-03-31 |
Dana Farber Cancer Institute, Inc. |
COMPOSITIONS AND PROCEDURES FOR ENHANCING ANTIBODY-MEDIATED RECEPTOR SIGNALING
|
|
CN113603780B
(zh)
|
2017-03-28 |
2022-07-01 |
礼进生物医药科技(上海)有限公司 |
用于增强肿瘤微环境中免疫应答的治疗剂和方法
|
|
TWI826364B
(zh)
|
2017-04-03 |
2023-12-21 |
德商因夫萊亞斯有限公司 |
活性抑制劑於發炎性疾病之治療
|
|
CA3120566C
(en)
|
2017-04-07 |
2023-12-12 |
Kookmin University Industry Academy Cooperation Foundation |
Antibody fc variants for increased blood half-life
|
|
US20200148779A1
(en)
|
2017-05-25 |
2020-05-14 |
Bristol-Myers Squibb Company |
MODIFIED IgG1 Fc DOMAINS AND ANTI-CD40 DOMAIN ANTIBODY FUSIONS THEREWITH
|
|
US20200299400A1
(en)
|
2017-05-25 |
2020-09-24 |
Bristol-Myers Squibb Company |
Antibodies comprising modified heavy constant regions
|
|
EP3635005A1
(en)
|
2017-06-07 |
2020-04-15 |
Genmab B.V. |
Therapeutic antibodies based on mutated igg hexamers
|
|
TWI786132B
(zh)
|
2017-06-23 |
2022-12-11 |
德商因夫萊亞斯有限公司 |
活性抑制劑於發炎性疾病之治療
|
|
CA3078732A1
(en)
|
2017-10-31 |
2019-05-09 |
Chemocentryx, Inc. |
C5ar inhibitor reduction of urinary scd163
|
|
CA3274059A1
(en)
*
|
2017-12-13 |
2026-03-02 |
Regeneron Pharmaceuticals, Inc. |
Anti-c5 antibody combinations and uses thereof
|
|
CN117924477A
(zh)
|
2017-12-19 |
2024-04-26 |
洛克菲勒大学 |
具有改进的效应子功能的人IgG Fc结构域变体
|
|
US20210070860A1
(en)
|
2018-03-21 |
2021-03-11 |
Dana-Farber Cancer Institute, Inc. |
Fc variant compositions and methods of use thereof
|
|
US20200376135A1
(en)
|
2018-10-23 |
2020-12-03 |
Magenta Therapeutics, Inc. |
Fc silenced antibody drug conjugates (adcs) and uses thereof
|
|
EP3887397A1
(en)
|
2018-11-28 |
2021-10-06 |
Bristol-Myers Squibb Company |
Antibodies comprising modified heavy constant regions
|
|
JP7617012B2
(ja)
|
2019-03-14 |
2025-01-17 |
モルフォシス・アーゲー |
C5aRを標的とする抗体
|
|
MA55818A
(fr)
*
|
2019-04-29 |
2022-03-16 |
Immunogen Inc |
Anticorps et immunoconjugués de fr-alpha biparatopique
|
|
US20220306735A1
(en)
|
2019-08-30 |
2022-09-29 |
University Of Kansas |
Compositions including igg fc mutations and uses thereof
|
|
TWI869528B
(zh)
|
2020-01-13 |
2025-01-11 |
美商威特拉公司 |
C5ar1抗體分子及其用途
|
|
WO2021180063A1
(en)
|
2020-03-09 |
2021-09-16 |
I-Mab Biopharma Co., Ltd. |
Methods for detecting and quantifying biological modifications in antibodies
|
|
PH12022552556A1
(en)
|
2020-03-27 |
2024-04-22 |
Inflarx Gmbh |
Inhibitors of c5a for the treatment of corona virus infection
|
|
CA3173944A1
(en)
|
2021-01-13 |
2022-07-21 |
Visterra, Inc. |
Humanized complement 5a receptor 1 antibodies and methods of use thereof
|