JP2024502258A5 - - Google Patents
Info
- Publication number
- JP2024502258A5 JP2024502258A5 JP2023537694A JP2023537694A JP2024502258A5 JP 2024502258 A5 JP2024502258 A5 JP 2024502258A5 JP 2023537694 A JP2023537694 A JP 2023537694A JP 2023537694 A JP2023537694 A JP 2023537694A JP 2024502258 A5 JP2024502258 A5 JP 2024502258A5
- Authority
- JP
- Japan
- Prior art keywords
- indole
- triazole
- methoxy
- chloro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063128949P | 2020-12-22 | 2020-12-22 | |
| US63/128,949 | 2020-12-22 | ||
| PCT/IB2021/062029 WO2022137085A1 (en) | 2020-12-22 | 2021-12-20 | Indole derivatives useful in treating conditions associated with cgas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024502258A JP2024502258A (ja) | 2024-01-18 |
| JP2024502258A5 true JP2024502258A5 (https=) | 2025-01-06 |
Family
ID=79164465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023537694A Pending JP2024502258A (ja) | 2020-12-22 | 2021-12-20 | Ｃｇａｓに関連する状態の処置に有用なインドール誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US12404261B2 (https=) |
| EP (1) | EP4267564A1 (https=) |
| JP (1) | JP2024502258A (https=) |
| KR (1) | KR20230124665A (https=) |
| CN (1) | CN116635382A (https=) |
| AR (1) | AR124443A1 (https=) |
| AU (1) | AU2021404953A1 (https=) |
| CA (1) | CA3202212A1 (https=) |
| CL (1) | CL2023001859A1 (https=) |
| CO (1) | CO2023007954A2 (https=) |
| CR (1) | CR20230282A (https=) |
| DO (1) | DOP2023000129A (https=) |
| EC (1) | ECSP23045506A (https=) |
| IL (1) | IL303913A (https=) |
| JO (1) | JOP20230146A1 (https=) |
| MX (1) | MX2023007467A (https=) |
| PE (1) | PE20240229A1 (https=) |
| PY (1) | PY21111338A (https=) |
| SA (1) | SA523441335B1 (https=) |
| TW (1) | TW202241873A (https=) |
| UY (1) | UY39579A (https=) |
| WO (1) | WO2022137085A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| CA3194067A1 (en) | 2020-09-15 | 2022-03-24 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2023235809A1 (en) * | 2022-06-02 | 2023-12-07 | Eli Lilly And Company | Cgas inhibitors |
| TW202430156A (zh) | 2022-10-18 | 2024-08-01 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | 化合物 |
| KR20250131845A (ko) * | 2022-12-20 | 2025-09-03 | 벤투스 테라퓨틱스 유에스 인코포레이티드 | 고리형 gmp-amp 생성효소 억제제로서 싸이아다이아졸 유도체 및 이의 용도 |
| AU2023409125A1 (en) | 2022-12-21 | 2025-06-26 | Eli Lilly And Company | Azepino[4,5-b]indolone cgas inhibitors |
| TW202440093A (zh) * | 2023-03-06 | 2024-10-16 | 香港商英矽智能科技知識產權有限公司 | Cdk8/19雙重抑制劑及其使用方法 |
| WO2025215082A1 (en) * | 2024-04-11 | 2025-10-16 | Glaxosmithkline Intellectual Property Development Limited | Fused azines for the treatment of inflammatory diseases |
| WO2025231011A1 (en) * | 2024-05-01 | 2025-11-06 | Omniab, Inc. | Heteroarylindole inhibitors of apol-1 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20040874A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici ed azaindolici con azione antitumorale |
| EA200901212A1 (ru) * | 2007-03-29 | 2010-04-30 | Новартис Аг | 3-имидазолилиндолы, предназначенные для лечения пролиферативных заболеваний |
| MX2010014394A (es) | 2008-06-20 | 2011-05-19 | Rottapharm Spa | Derivados de 6-1h-imidazo-quinazolina y quinolinas, nuevos inhibidores de monoamina oxidasa y ligandos del receptor de imidazolina. |
| US9096579B2 (en) | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| EP2934598B1 (en) * | 2012-12-19 | 2018-04-18 | Board Of Regents, The University Of Texas System | Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway |
| US9840533B2 (en) * | 2013-04-29 | 2017-12-12 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| WO2016103037A1 (en) | 2014-12-22 | 2016-06-30 | Akarna Therapeutics, Ltd. | Fused bicyclic compounds for the treatment of disease |
| WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| SG11202002218VA (en) | 2017-09-15 | 2020-04-29 | Aduro Biotech Inc | Pyrazolopyrimidinone compounds and uses thereof |
| BR112020016008A2 (pt) * | 2018-02-05 | 2020-12-15 | The Rockefeller University | Composto, método para inibir uma resposta inflamatória em um paciente, método para inibir inflamação em um paciente, método para inibir expressão de interferon ativada por dsdna em um mamífero, método para tratar metástase de câncer em um paciente e formulação farmacêutica |
| MX2020008265A (es) * | 2018-02-16 | 2020-09-21 | UCB Biopharma SRL | Derivados farmaceuticos del anillo heterobiciclico 6,5. |
| WO2020123422A1 (en) | 2018-12-10 | 2020-06-18 | Aduro Biotech, Inc. | Imidazopyridazinone compounds and uses thereof |
| CA3125626A1 (en) | 2019-01-04 | 2020-07-09 | Bellbrook Labs, Llc | Inhibitors of cgas activity as therapeutic agents |
| US12522603B2 (en) | 2019-03-13 | 2026-01-13 | The Rockefeller University | Inhibitors of gas for treating autoinflammatory diseases and cancer metastasis |
| WO2021209475A1 (en) | 2020-04-16 | 2021-10-21 | F. Hoffmann-La Roche Ag | Sulfamoylamide derivatives |
| US20230192623A1 (en) | 2020-04-16 | 2023-06-22 | Hoffmann-La Roche Inc. | Indazole Derivatives |
| JP2023522327A (ja) | 2020-04-16 | 2023-05-30 | エフ． ホフマン－ラ ロシュ アーゲー | ベンズイミダゾール誘導体 |
| WO2021209473A1 (en) | 2020-04-16 | 2021-10-21 | F. Hoffmann-La Roche Ag | Biphenyl derivatives |
| US20230348398A1 (en) | 2020-04-16 | 2023-11-02 | Hoffmann-La Roche Inc. | Benzimidazole derivatives |
| KR20230062845A (ko) | 2020-09-03 | 2023-05-09 | 이뮨센서 테라퓨틱스, 인코포레이티드 | 퀴놀린 cgas 길항제 화합물 |
| AU2021349249A1 (en) | 2020-09-24 | 2023-04-13 | Ventus Therapeutics U.S., Inc. | Pyrido(4,3-b)indole derivatives and their use as pharmaceuticals |
-
2021
- 2021-12-20 WO PCT/IB2021/062029 patent/WO2022137085A1/en not_active Ceased
- 2021-12-20 CR CR20230282A patent/CR20230282A/es unknown
- 2021-12-20 JP JP2023537694A patent/JP2024502258A/ja active Pending
- 2021-12-20 AU AU2021404953A patent/AU2021404953A1/en active Pending
- 2021-12-20 US US17/645,071 patent/US12404261B2/en active Active
- 2021-12-20 UY UY0001039579A patent/UY39579A/es unknown
- 2021-12-20 PY PY202121111338A patent/PY21111338A/es unknown
- 2021-12-20 KR KR1020237024854A patent/KR20230124665A/ko active Pending
- 2021-12-20 AR ARP210103590A patent/AR124443A1/es unknown
- 2021-12-20 CA CA3202212A patent/CA3202212A1/en active Pending
- 2021-12-20 PE PE2023001937A patent/PE20240229A1/es unknown
- 2021-12-20 EP EP21834940.5A patent/EP4267564A1/en active Pending
- 2021-12-20 TW TW110147655A patent/TW202241873A/zh unknown
- 2021-12-20 IL IL303913A patent/IL303913A/en unknown
- 2021-12-20 MX MX2023007467A patent/MX2023007467A/es unknown
- 2021-12-20 CN CN202180079723.3A patent/CN116635382A/zh active Pending
-
2023
- 2023-06-20 JO JOJO/P/2023/0146A patent/JOP20230146A1/ar unknown
- 2023-06-20 CO CONC2023/0007954A patent/CO2023007954A2/es unknown
- 2023-06-20 CL CL2023001859A patent/CL2023001859A1/es unknown
- 2023-06-20 EC ECSENADI202345506A patent/ECSP23045506A/es unknown
- 2023-06-21 DO DO2023000129A patent/DOP2023000129A/es unknown
- 2023-06-21 SA SA523441335A patent/SA523441335B1/ar unknown
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