JP2024123233A5 - - Google Patents
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- JP2024123233A5 JP2024123233A5 JP2024103130A JP2024103130A JP2024123233A5 JP 2024123233 A5 JP2024123233 A5 JP 2024123233A5 JP 2024103130 A JP2024103130 A JP 2024103130A JP 2024103130 A JP2024103130 A JP 2024103130A JP 2024123233 A5 JP2024123233 A5 JP 2024123233A5
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- Prior art keywords
- marker
- methylation
- max
- nucleic acid
- methylation marker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003550 marker Substances 0.000 claims 111
- 230000011987 methylation Effects 0.000 claims 70
- 238000007069 methylation reaction Methods 0.000 claims 70
- 108090000623 proteins and genes Proteins 0.000 claims 46
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 29
- 239000002751 oligonucleotide probe Substances 0.000 claims 29
- 150000007523 nucleic acids Chemical class 0.000 claims 26
- -1 FLJ45983 Proteins 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 22
- 108020004414 DNA Proteins 0.000 claims 19
- 101000839095 Homo sapiens Homeodomain-only protein Proteins 0.000 claims 19
- 101001010832 Homo sapiens Non-homologous end joining factor IFFO1 Proteins 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 239000000523 sample Substances 0.000 claims 16
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 12
- 102100028798 Homeodomain-only protein Human genes 0.000 claims 12
- 102100029980 Non-homologous end joining factor IFFO1 Human genes 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 12
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 11
- 230000000295 complement effect Effects 0.000 claims 9
- 102100026345 Homeobox protein BarH-like 1 Human genes 0.000 claims 8
- 101000766185 Homo sapiens Homeobox protein BarH-like 1 Proteins 0.000 claims 8
- 101000642630 Homo sapiens Sine oculis-binding protein homolog Proteins 0.000 claims 8
- 101000915606 Homo sapiens Zinc finger protein 781 Proteins 0.000 claims 8
- 102100036670 Sine oculis-binding protein homolog Human genes 0.000 claims 8
- 102100028582 Zinc finger protein 781 Human genes 0.000 claims 8
- 102100035951 GRB2-associated and regulator of MAPK protein 2 Human genes 0.000 claims 7
- 102100021090 Homeobox protein Hox-A9 Human genes 0.000 claims 7
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- 101001021431 Homo sapiens GRB2-associated and regulator of MAPK protein 2 Proteins 0.000 claims 7
- 101001019752 Homo sapiens Homeobox protein Hox-B2 Proteins 0.000 claims 7
- 102100032251 Pro-thyrotropin-releasing hormone Human genes 0.000 claims 7
- 101800004623 Thyrotropin-releasing hormone Proteins 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 108010027263 homeobox protein HOXA9 Proteins 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 102100025908 5-oxoprolinase Human genes 0.000 claims 3
- 102100029233 Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Human genes 0.000 claims 3
- 102100034594 Angiopoietin-1 Human genes 0.000 claims 3
- 102100034269 Ankyrin repeat domain-containing protein 13B Human genes 0.000 claims 3
- 108010040168 Bcl-2-Like Protein 11 Proteins 0.000 claims 3
- 102000001765 Bcl-2-Like Protein 11 Human genes 0.000 claims 3
- 102100023994 Beta-1,3-galactosyltransferase 6 Human genes 0.000 claims 3
- 102100026437 Branched-chain-amino-acid aminotransferase, cytosolic Human genes 0.000 claims 3
- 102100032537 Calpain-2 catalytic subunit Human genes 0.000 claims 3
- 102100026196 Class E basic helix-loop-helix protein 23 Human genes 0.000 claims 3
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- 102100024812 DNA (cytosine-5)-methyltransferase 3A Human genes 0.000 claims 3
- 108010024491 DNA Methyltransferase 3A Proteins 0.000 claims 3
- 102100032501 Death-inducer obliterator 1 Human genes 0.000 claims 3
- 102100031597 Dedicator of cytokinesis protein 2 Human genes 0.000 claims 3
- 102100035316 Doublesex- and mab-3-related transcription factor A2 Human genes 0.000 claims 3
- 101000809594 Escherichia coli (strain K12) Shikimate kinase 1 Proteins 0.000 claims 3
- 102100040612 Fermitin family homolog 3 Human genes 0.000 claims 3
- 102100035292 Fibroblast growth factor 14 Human genes 0.000 claims 3
- 102100022626 Glutamate receptor ionotropic, NMDA 2D Human genes 0.000 claims 3
- 102100022374 Homeobox protein DLX-4 Human genes 0.000 claims 3
- 102100023823 Homeobox protein EMX1 Human genes 0.000 claims 3
- 102100027876 Homeobox protein Nkx-2.6 Human genes 0.000 claims 3
- 101000720962 Homo sapiens 5-oxoprolinase Proteins 0.000 claims 3
- 101000634075 Homo sapiens Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Proteins 0.000 claims 3
- 101000924552 Homo sapiens Angiopoietin-1 Proteins 0.000 claims 3
- 101000780147 Homo sapiens Ankyrin repeat domain-containing protein 13B Proteins 0.000 claims 3
- 101100218706 Homo sapiens BHLHE23 gene Proteins 0.000 claims 3
- 101000904594 Homo sapiens Beta-1,3-galactosyltransferase 6 Proteins 0.000 claims 3
- 101000766268 Homo sapiens Branched-chain-amino-acid aminotransferase, cytosolic Proteins 0.000 claims 3
- 101000867692 Homo sapiens Calpain-2 catalytic subunit Proteins 0.000 claims 3
- 101000875398 Homo sapiens Cytochrome P450 26C1 Proteins 0.000 claims 3
- 101000869896 Homo sapiens Death-inducer obliterator 1 Proteins 0.000 claims 3
- 101000866237 Homo sapiens Dedicator of cytokinesis protein 2 Proteins 0.000 claims 3
- 101000949728 Homo sapiens Doublesex- and mab-3-related transcription factor A2 Proteins 0.000 claims 3
- 101000749644 Homo sapiens Fermitin family homolog 3 Proteins 0.000 claims 3
- 101000878181 Homo sapiens Fibroblast growth factor 14 Proteins 0.000 claims 3
- 101000972840 Homo sapiens Glutamate receptor ionotropic, NMDA 2D Proteins 0.000 claims 3
- 101000901614 Homo sapiens Homeobox protein DLX-4 Proteins 0.000 claims 3
- 101001048956 Homo sapiens Homeobox protein EMX1 Proteins 0.000 claims 3
- 101000632193 Homo sapiens Homeobox protein Nkx-2.6 Proteins 0.000 claims 3
- 101001027143 Homo sapiens Kelch domain-containing protein 7B Proteins 0.000 claims 3
- 101001059535 Homo sapiens Megakaryocyte-associated tyrosine-protein kinase Proteins 0.000 claims 3
- 101000979347 Homo sapiens Nuclear factor 1 X-type Proteins 0.000 claims 3
- 101001123298 Homo sapiens PR domain zinc finger protein 14 Proteins 0.000 claims 3
- 101000782074 Homo sapiens Palmitoyltransferase ZDHHC1 Proteins 0.000 claims 3
- 101001117305 Homo sapiens Prostaglandin D2 receptor Proteins 0.000 claims 3
- 101000613620 Homo sapiens Protein mono-ADP-ribosyltransferase PARP15 Proteins 0.000 claims 3
- 101000712958 Homo sapiens Ras association domain-containing protein 1 Proteins 0.000 claims 3
- 101000752241 Homo sapiens Rho guanine nucleotide exchange factor 4 Proteins 0.000 claims 3
- 101000703741 Homo sapiens Short stature homeobox protein 2 Proteins 0.000 claims 3
- 101000863692 Homo sapiens Ski oncogene Proteins 0.000 claims 3
- 101000653757 Homo sapiens Sphingosine 1-phosphate receptor 4 Proteins 0.000 claims 3
- 101000661451 Homo sapiens Succinate-CoA ligase [GDP-forming] subunit beta, mitochondrial Proteins 0.000 claims 3
- 101000653634 Homo sapiens T-box transcription factor TBX15 Proteins 0.000 claims 3
- 101000640735 Homo sapiens TSC22 domain family protein 4 Proteins 0.000 claims 3
- 101000800047 Homo sapiens Testican-2 Proteins 0.000 claims 3
- 101000642459 Homo sapiens Transcription factor Sp9 Proteins 0.000 claims 3
- 101000915477 Homo sapiens Zinc finger MIZ domain-containing protein 1 Proteins 0.000 claims 3
- 101000976579 Homo sapiens Zinc finger protein 132 Proteins 0.000 claims 3
- 101000915652 Homo sapiens Zinc finger protein 329 Proteins 0.000 claims 3
- 101000915607 Homo sapiens Zinc finger protein 671 Proteins 0.000 claims 3
- 102100037648 Kelch domain-containing protein 7B Human genes 0.000 claims 3
- 102100028905 Megakaryocyte-associated tyrosine-protein kinase Human genes 0.000 claims 3
- 102100023049 Nuclear factor 1 X-type Human genes 0.000 claims 3
- 102100028974 PR domain zinc finger protein 14 Human genes 0.000 claims 3
- 102100036609 Palmitoyltransferase ZDHHC1 Human genes 0.000 claims 3
- 102100024212 Prostaglandin D2 receptor Human genes 0.000 claims 3
- 102100040846 Protein mono-ADP-ribosyltransferase PARP15 Human genes 0.000 claims 3
- 102100033243 Ras association domain-containing protein 1 Human genes 0.000 claims 3
- 102100021709 Rho guanine nucleotide exchange factor 4 Human genes 0.000 claims 3
- 102100031976 Short stature homeobox protein 2 Human genes 0.000 claims 3
- 102100029969 Ski oncogene Human genes 0.000 claims 3
- 102100029803 Sphingosine 1-phosphate receptor 4 Human genes 0.000 claims 3
- 102100037788 Succinate-CoA ligase [GDP-forming] subunit beta, mitochondrial Human genes 0.000 claims 3
- 102100029853 T-box transcription factor TBX15 Human genes 0.000 claims 3
- 102100033848 TSC22 domain family protein 4 Human genes 0.000 claims 3
- 102100033371 Testican-2 Human genes 0.000 claims 3
- 102100036395 Transcription factor Sp9 Human genes 0.000 claims 3
- 102100028535 Zinc finger MIZ domain-containing protein 1 Human genes 0.000 claims 3
- 102100023572 Zinc finger protein 132 Human genes 0.000 claims 3
- 102100029023 Zinc finger protein 329 Human genes 0.000 claims 3
- 102100028943 Zinc finger protein 671 Human genes 0.000 claims 3
- 208000037841 lung tumor Diseases 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108091008146 restriction endonucleases Proteins 0.000 claims 3
- 101150104383 ALOX5AP gene Proteins 0.000 claims 2
- 102100022900 Actin, cytoplasmic 1 Human genes 0.000 claims 2
- 108010085238 Actins Proteins 0.000 claims 2
- 102100040026 Agrin Human genes 0.000 claims 2
- 108090000652 Flap endonucleases Proteins 0.000 claims 2
- 101000959594 Homo sapiens Agrin Proteins 0.000 claims 2
- 101100236114 Mus musculus Lrrfip1 gene Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091006628 SLC12A8 Proteins 0.000 claims 2
- 102100036751 Solute carrier family 12 member 8 Human genes 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000007855 methylation-specific PCR Methods 0.000 claims 2
- 239000012474 protein marker Substances 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100040079 A-kinase anchor protein 4 Human genes 0.000 claims 1
- 108010076804 DNA Restriction Enzymes Proteins 0.000 claims 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
- 102000004150 Flap endonucleases Human genes 0.000 claims 1
- 102100036304 G antigen 12B/C/D/E Human genes 0.000 claims 1
- 101000890604 Homo sapiens A-kinase anchor protein 4 Proteins 0.000 claims 1
- 101001074834 Homo sapiens G antigen 12B/C/D/E Proteins 0.000 claims 1
- 101000783723 Homo sapiens Leucine-rich alpha-2-glycoprotein Proteins 0.000 claims 1
- 101001005720 Homo sapiens Melanoma-associated antigen 4 Proteins 0.000 claims 1
- 101000947115 Homo sapiens Protein CASC3 Proteins 0.000 claims 1
- 101000877857 Homo sapiens Protein FAM83A Proteins 0.000 claims 1
- 101001086862 Homo sapiens Pulmonary surfactant-associated protein B Proteins 0.000 claims 1
- 102100035987 Leucine-rich alpha-2-glycoprotein Human genes 0.000 claims 1
- 102100025077 Melanoma-associated antigen 4 Human genes 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 102100035601 Protein CASC3 Human genes 0.000 claims 1
- 102100035446 Protein FAM83A Human genes 0.000 claims 1
- 102100032617 Pulmonary surfactant-associated protein B Human genes 0.000 claims 1
- 108091026838 U1 spliceosomal RNA Proteins 0.000 claims 1
- 108091026822 U6 spliceosomal RNA Proteins 0.000 claims 1
- 108010026102 Vitamin D3 24-Hydroxylase Proteins 0.000 claims 1
- 102000013387 Vitamin D3 24-Hydroxylase Human genes 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 238000009585 enzyme analysis Methods 0.000 claims 1
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 238000012175 pyrosequencing Methods 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862771965P | 2018-11-27 | 2018-11-27 | |
| US62/771,965 | 2018-11-27 | ||
| JP2021530259A JP7512278B2 (ja) | 2018-11-27 | 2019-11-26 | 肺腫瘍の検出におけるメチル化ｄｎａ、ｒｎａ、及びタンパク質の特性決定 |
| PCT/US2019/063401 WO2020112869A1 (en) | 2018-11-27 | 2019-11-26 | Characterizing methylated dna, rna, and proteins in the detection of lung neoplasia |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021530259A Division JP7512278B2 (ja) | 2018-11-27 | 2019-11-26 | 肺腫瘍の検出におけるメチル化ｄｎａ、ｒｎａ、及びタンパク質の特性決定 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024123233A JP2024123233A (ja) | 2024-09-10 |
| JP2024123233A5 true JP2024123233A5 (https=) | 2024-11-21 |
Family
ID=70853661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021530259A Active JP7512278B2 (ja) | 2018-11-27 | 2019-11-26 | 肺腫瘍の検出におけるメチル化ｄｎａ、ｒｎａ、及びタンパク質の特性決定 |
| JP2024103130A Pending JP2024123233A (ja) | 2018-11-27 | 2024-06-26 | 肺腫瘍の検出におけるメチル化ｄｎａ、ｒｎａ、及びタンパク質の特性決定 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021530259A Active JP7512278B2 (ja) | 2018-11-27 | 2019-11-26 | 肺腫瘍の検出におけるメチル化ｄｎａ、ｒｎａ、及びタンパク質の特性決定 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220136058A1 (https=) |
| EP (1) | EP3886878A4 (https=) |
| JP (2) | JP7512278B2 (https=) |
| KR (1) | KR102945867B1 (https=) |
| CN (1) | CN113423410A (https=) |
| AU (1) | AU2019389008A1 (https=) |
| BR (1) | BR112021009795A2 (https=) |
| CA (1) | CA3119329A1 (https=) |
| MX (1) | MX2021005963A (https=) |
| WO (1) | WO2020112869A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2816122A1 (en) | 2008-02-15 | 2014-12-24 | Mayo Foundation For Medical Education And Research | Detecting neoplasm from a stool sample |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| CA2902916C (en) | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| CN120700143A (zh) | 2014-03-31 | 2025-09-26 | 梅奥医学教育和研究基金会 | 检测结直肠赘生物 |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10435755B2 (en) | 2015-03-27 | 2019-10-08 | Exact Sciences Development Company, Llc | Detecting esophageal disorders |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| CN108350485A (zh) | 2015-10-30 | 2018-07-31 | 精密科学发展有限责任公司 | 血浆dna的多重扩增检测测定以及分离和检测 |
| CN109563546B (zh) | 2016-05-05 | 2022-09-09 | 精密科学发展有限责任公司 | 通过分析甲基化dna来检测肺肿瘤 |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| JP7277460B2 (ja) | 2017-11-30 | 2023-05-19 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 乳癌の検出 |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| CA3127329A1 (en) | 2019-01-24 | 2020-07-30 | Mayo Foundation For Medical Education And Research | Detecting endometrial cancer |
| CA3149601A1 (en) * | 2019-08-27 | 2021-03-04 | Scott Morris | Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia |
| EP4031683A4 (en) | 2019-09-16 | 2024-01-17 | Exact Sciences Corporation | Structure and temperature-dependent flap endonuclease substrates |
| US11702704B2 (en) | 2019-10-31 | 2023-07-18 | Mayo Foundation For Medical Education And Research | Detecting ovarian cancer |
| US11898199B2 (en) | 2019-11-11 | 2024-02-13 | Universal Diagnostics, S.A. | Detection of colorectal cancer and/or advanced adenomas |
| US12467096B2 (en) | 2020-05-15 | 2025-11-11 | Universal Diagnostics, S.A. | Methods and systems for identifying methylation biomarkers |
| EP4150121A1 (en) | 2020-06-30 | 2023-03-22 | Universal Diagnostics, S.A. | Systems and methods for detection of multiple cancer types |
| EP3945135A1 (en) * | 2020-07-27 | 2022-02-02 | Les Laboratoires Servier | Biomarkers for diagnosing and monitoring lung cancer |
| KR20230150814A (ko) * | 2021-01-29 | 2023-10-31 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 다양한 유형의 암에 대한 존재 또는 부재의 검출 |
| CN115505640B (zh) * | 2021-06-22 | 2026-04-07 | 江苏鹍远生物科技股份有限公司 | 检测肺癌的dna甲基化标志物及应用 |
| CN115725734B (zh) * | 2022-08-10 | 2023-10-13 | 人和未来生物科技（长沙）有限公司 | Znf781基因在制备宫颈癌诊断试剂中的应用 |
| US12606872B2 (en) | 2022-11-16 | 2026-04-21 | Universal Diagnostics, S.A. | Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers |
| CN117683877A (zh) * | 2023-12-19 | 2024-03-12 | 上海交通大学医学院 | 一种诊断或治疗免疫系统疾病的生物标志物或靶点 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070264659A1 (en) * | 2006-05-11 | 2007-11-15 | Sungwhan An | Lung cancer biomarker discovery |
| JPWO2010064702A1 (ja) | 2008-12-05 | 2012-05-10 | 国立大学法人 東京大学 | 癌の予後を予測するためのバイオマーカー |
| WO2010074924A1 (en) * | 2008-12-23 | 2010-07-01 | University Of Utah Research Foundation | Identification and regulation of a novel dna demethylase system |
| EP2761025A1 (en) * | 2011-09-30 | 2014-08-06 | Genentech, Inc. | Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells |
| WO2013070950A1 (en) * | 2011-11-08 | 2013-05-16 | University Of Southern California | Identification of a dna methylation marker for blood-based detection of ovarian cancer |
| US9546403B1 (en) * | 2011-12-14 | 2017-01-17 | University Of Utah Research Foundation | Substrate for methylated DNA testing |
| CA3183545C (en) * | 2014-12-12 | 2026-01-13 | Exact Sciences Corporation | Compositions and methods for performing methylation detection assays |
| JP6877704B2 (ja) * | 2015-11-16 | 2021-05-26 | 公立大学法人名古屋市立大学 | 膵臓癌の検出のための方法及びキット |
| CN109563546B (zh) * | 2016-05-05 | 2022-09-09 | 精密科学发展有限责任公司 | 通过分析甲基化dna来检测肺肿瘤 |
| WO2017223216A1 (en) * | 2016-06-21 | 2017-12-28 | The Wistar Institute Of Anatomy And Biology | Compositions and methods for diagnosing lung cancers using gene expression profiles |
| EP3978624B1 (en) * | 2016-07-19 | 2025-03-26 | Exact Sciences Corporation | Methylated control dna |
-
2019
- 2019-11-26 WO PCT/US2019/063401 patent/WO2020112869A1/en not_active Ceased
- 2019-11-26 EP EP19890483.1A patent/EP3886878A4/en active Pending
- 2019-11-26 CA CA3119329A patent/CA3119329A1/en active Pending
- 2019-11-26 CN CN201980077665.3A patent/CN113423410A/zh active Pending
- 2019-11-26 JP JP2021530259A patent/JP7512278B2/ja active Active
- 2019-11-26 BR BR112021009795-3A patent/BR112021009795A2/pt unknown
- 2019-11-26 KR KR1020217019972A patent/KR102945867B1/ko active Active
- 2019-11-26 AU AU2019389008A patent/AU2019389008A1/en active Pending
- 2019-11-26 MX MX2021005963A patent/MX2021005963A/es unknown
- 2019-11-26 US US17/297,356 patent/US20220136058A1/en active Pending
-
2024
- 2024-06-26 JP JP2024103130A patent/JP2024123233A/ja active Pending
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