CN113423410A - 在肺肿瘤检测中表征甲基化dna、rna和蛋白质 - Google Patents

在肺肿瘤检测中表征甲基化dna、rna和蛋白质 Download PDF

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CN113423410A
CN113423410A CN201980077665.3A CN201980077665A CN113423410A CN 113423410 A CN113423410 A CN 113423410A CN 201980077665 A CN201980077665 A CN 201980077665A CN 113423410 A CN113423410 A CN 113423410A
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dna
methylation
artificial sequence
max
marker
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Chinese (zh)
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H·阿拉维
G·P·利德加德
M·贾库莫普洛斯
D·A·阿尔奎斯特
W·R·泰勒
D·马奥尼
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Exact Sciences Corp
Mayo Clinic in Florida
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Exact Sciences Development Co LLC
Mayo Clinic in Florida
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201980077665.3A 2018-11-27 2019-11-26 在肺肿瘤检测中表征甲基化dna、rna和蛋白质 Pending CN113423410A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862771965P 2018-11-27 2018-11-27
US62/771965 2018-11-27
PCT/US2019/063401 WO2020112869A1 (en) 2018-11-27 2019-11-26 Characterizing methylated dna, rna, and proteins in the detection of lung neoplasia

Publications (1)

Publication Number Publication Date
CN113423410A true CN113423410A (zh) 2021-09-21

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CN201980077665.3A Pending CN113423410A (zh) 2018-11-27 2019-11-26 在肺肿瘤检测中表征甲基化dna、rna和蛋白质

Country Status (10)

Country Link
US (1) US20220136058A1 (https=)
EP (1) EP3886878A4 (https=)
JP (2) JP7512278B2 (https=)
KR (1) KR102945867B1 (https=)
CN (1) CN113423410A (https=)
AU (1) AU2019389008A1 (https=)
BR (1) BR112021009795A2 (https=)
CA (1) CA3119329A1 (https=)
MX (1) MX2021005963A (https=)
WO (1) WO2020112869A1 (https=)

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EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
EP4234722A3 (en) 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN108138235B (zh) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 检测胃肿瘤
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
CN116064796A (zh) 2016-05-05 2023-05-05 精密科学公司 通过分析甲基化dna来检测肺肿瘤
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
US10975443B2 (en) 2017-11-30 2021-04-13 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
US12584177B2 (en) 2019-01-24 2026-03-24 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
WO2021041726A1 (en) * 2019-08-27 2021-03-04 Exact Sciences Development Company, Llc Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
WO2021055508A1 (en) 2019-09-16 2021-03-25 Exact Sciences Development Company, Llc Structure and temperature-dependent flap endonuclease substrates
CA3154354A1 (en) 2019-10-31 2021-05-06 William R. Taylor Detecting ovarian cancer
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
WO2022002424A1 (en) 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
EP3945135A1 (en) * 2020-07-27 2022-02-02 Les Laboratoires Servier Biomarkers for diagnosing and monitoring lung cancer
AU2022213409A1 (en) * 2021-01-29 2023-08-17 Exact Sciences Corporation Detecting the presence or absence of multiple types of cancer
CN115505640B (zh) * 2021-06-22 2026-04-07 江苏鹍远生物科技股份有限公司 检测肺癌的dna甲基化标志物及应用
CN115725734B (zh) * 2022-08-10 2023-10-13 人和未来生物科技（长沙）有限公司 Znf781基因在制备宫颈癌诊断试剂中的应用
US12606872B2 (en) 2022-11-16 2026-04-21 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers
CN117683877A (zh) * 2023-12-19 2024-03-12 上海交通大学医学院 一种诊断或治疗免疫系统疾病的生物标志物或靶点

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CN107003314A (zh) * 2014-12-12 2017-08-01 精密科学公司 用于进行甲基化检测测定的组合物和方法
WO2017192221A1 (en) * 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated dna

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JPWO2010064702A1 (ja) * 2008-12-05 2012-05-10 国立大学法人 東京大学 癌の予後を予測するためのバイオマーカー
JP2014531213A (ja) * 2011-09-30 2014-11-27 ジェネンテック， インコーポレイテッド 上皮又は間葉の表現型の診断用メチル化マーカー、及び腫瘍又は腫瘍細胞におけるｅｇｆｒキナーゼ阻害薬に対する応答
WO2013070950A1 (en) * 2011-11-08 2013-05-16 University Of Southern California Identification of a dna methylation marker for blood-based detection of ovarian cancer
US9546403B1 (en) * 2011-12-14 2017-01-17 University Of Utah Research Foundation Substrate for methylated DNA testing
JP6877704B2 (ja) * 2015-11-16 2021-05-26 公立大学法人名古屋市立大学 膵臓癌の検出のための方法及びキット
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EP3488004B1 (en) * 2016-07-19 2021-10-06 Exact Sciences Development Company, LLC Methylated control dna

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WO2010074924A1 (en) * 2008-12-23 2010-07-01 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
CN107003314A (zh) * 2014-12-12 2017-08-01 精密科学公司 用于进行甲基化检测测定的组合物和方法
WO2017192221A1 (en) * 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated dna

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Also Published As

Publication number Publication date
JP7512278B2 (ja) 2024-07-08
CA3119329A1 (en) 2020-06-04
KR102945867B1 (ko) 2026-03-31
US20220136058A1 (en) 2022-05-05
KR20210099044A (ko) 2021-08-11
EP3886878A4 (en) 2022-11-02
EP3886878A1 (en) 2021-10-06
WO2020112869A1 (en) 2020-06-04
BR112021009795A2 (pt) 2021-08-17
JP2022513658A (ja) 2022-02-09
MX2021005963A (es) 2021-08-24
AU2019389008A1 (en) 2021-06-03
JP2024123233A (ja) 2024-09-10

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