JP2024116193A5 - - Google Patents
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- Publication number
- JP2024116193A5 JP2024116193A5 JP2024087359A JP2024087359A JP2024116193A5 JP 2024116193 A5 JP2024116193 A5 JP 2024116193A5 JP 2024087359 A JP2024087359 A JP 2024087359A JP 2024087359 A JP2024087359 A JP 2024087359A JP 2024116193 A5 JP2024116193 A5 JP 2024116193A5
- Authority
- JP
- Japan
- Prior art keywords
- bacteroides
- prokaryotic cell
- crispr system
- target
- crispr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091033409 CRISPR Proteins 0.000 claims 35
- 238000010354 CRISPR gene editing Methods 0.000 claims 33
- 210000001236 prokaryotic cell Anatomy 0.000 claims 30
- 238000000034 method Methods 0.000 claims 20
- 101710163270 Nuclease Proteins 0.000 claims 13
- 210000000349 chromosome Anatomy 0.000 claims 11
- 241000606125 Bacteroides Species 0.000 claims 8
- 230000001939 inductive effect Effects 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 108020005004 Guide RNA Proteins 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000008030 elimination Effects 0.000 claims 3
- 238000003379 elimination reaction Methods 0.000 claims 3
- 241001032450 Bacteroides cellulosilyticus Species 0.000 claims 2
- 241000606124 Bacteroides fragilis Species 0.000 claims 2
- 241001135228 Bacteroides ovatus Species 0.000 claims 2
- 241000168636 Bacteroides salanitronis Species 0.000 claims 2
- 241000606123 Bacteroides thetaiotaomicron Species 0.000 claims 2
- 241000606219 Bacteroides uniformis Species 0.000 claims 2
- 241000606215 Bacteroides vulgatus Species 0.000 claims 2
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims 2
- 101710096438 DNA-binding protein Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 101150090898 tdk gene Proteins 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 claims 1
- 229930101283 tetracycline Natural products 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962908130P | 2019-09-30 | 2019-09-30 | |
| US62/908,130 | 2019-09-30 | ||
| US201962909078P | 2019-10-01 | 2019-10-01 | |
| US62/909,078 | 2019-10-01 | ||
| US202063052825P | 2020-07-16 | 2020-07-16 | |
| US63/052,825 | 2020-07-16 | ||
| PCT/US2020/053304 WO2021067291A1 (en) | 2019-09-30 | 2020-09-29 | Modulation of microbiota compositions using targeted nucleases |
| JP2022520089A JP2022549519A (ja) | 2019-09-30 | 2020-09-29 | 標的化ヌクレアーゼを用いたマイクロバイオータ組成の調節 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022520089A Division JP2022549519A (ja) | 2019-09-30 | 2020-09-29 | 標的化ヌクレアーゼを用いたマイクロバイオータ組成の調節 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024116193A JP2024116193A (ja) | 2024-08-27 |
| JP2024116193A5 true JP2024116193A5 (https=) | 2024-10-11 |
Family
ID=72896108
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022520089A Pending JP2022549519A (ja) | 2019-09-30 | 2020-09-29 | 標的化ヌクレアーゼを用いたマイクロバイオータ組成の調節 |
| JP2024087359A Pending JP2024116193A (ja) | 2019-09-30 | 2024-05-29 | 標的化ヌクレアーゼを用いたマイクロバイオータ組成の調節 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022520089A Pending JP2022549519A (ja) | 2019-09-30 | 2020-09-29 | 標的化ヌクレアーゼを用いたマイクロバイオータ組成の調節 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210095273A1 (https=) |
| EP (1) | EP4038185A1 (https=) |
| JP (2) | JP2022549519A (https=) |
| KR (1) | KR20220051259A (https=) |
| CN (1) | CN114929873A (https=) |
| AU (1) | AU2020357816A1 (https=) |
| BR (1) | BR112022005831A2 (https=) |
| CA (1) | CA3152931A1 (https=) |
| IL (1) | IL291509A (https=) |
| WO (1) | WO2021067291A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021127209A1 (en) * | 2019-12-17 | 2021-06-24 | Sigma-Aldrich Co. Llc | Genome editing in bacteroides |
| CN116004688A (zh) * | 2021-10-21 | 2023-04-25 | 中国科学院深圳先进技术研究院 | 肠道菌拟杆菌的基因编辑方法与应用 |
| US20250034579A1 (en) * | 2021-12-07 | 2025-01-30 | Cornell University | Methods and compositions for genetically modifying human gut microbes |
| KR20240172712A (ko) * | 2023-05-31 | 2024-12-10 | 한국생명공학연구원 | 아커만시아 뮤시니필라 tars를 발현 및 분비하도록 설계된 프로바이오틱스 및 이의 제조를 위한 벡터 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002306849A1 (en) * | 2001-03-21 | 2002-10-08 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| JP5070051B2 (ja) * | 2004-06-07 | 2012-11-07 | クー バイオロジックス インク． | 癌を治療するための細菌組成物 |
| CA2682242A1 (en) * | 2007-03-28 | 2008-10-02 | Alimentary Health Limited | Probiotic bifidobacterium longum strain |
| US20110281762A1 (en) * | 2010-05-13 | 2011-11-17 | Sonnenburg Justin L | High throughput screening for anaerobic microorganisms |
| EP3241902B1 (en) * | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| WO2015006294A2 (en) * | 2013-07-10 | 2015-01-15 | President And Fellows Of Harvard College | Orthogonal cas9 proteins for rna-guided gene regulation and editing |
| WO2015148680A1 (en) * | 2014-03-25 | 2015-10-01 | Ginkgo Bioworks, Inc. | Methods and genetic systems for cell engineering |
| US11408007B2 (en) * | 2014-09-26 | 2022-08-09 | Yale University | Compositions and methods for biocontainment of microorganisms |
| CN107667173A (zh) * | 2015-05-06 | 2018-02-06 | 斯尼普技术有限公司 | 改变微生物种群和改善微生物群 |
| EP3307306A4 (en) * | 2015-06-10 | 2019-04-24 | Massachusetts Institute of Technology | GENE EXPRESSION IN BACTEROIDES |
| JP6886142B2 (ja) * | 2017-01-04 | 2021-06-16 | 国立大学法人 新潟大学 | 腸内細菌叢改善剤及びその使用 |
-
2020
- 2020-09-29 US US17/037,141 patent/US20210095273A1/en not_active Abandoned
- 2020-09-29 JP JP2022520089A patent/JP2022549519A/ja active Pending
- 2020-09-29 CA CA3152931A patent/CA3152931A1/en active Pending
- 2020-09-29 KR KR1020227010378A patent/KR20220051259A/ko not_active Ceased
- 2020-09-29 BR BR112022005831A patent/BR112022005831A2/pt unknown
- 2020-09-29 AU AU2020357816A patent/AU2020357816A1/en not_active Abandoned
- 2020-09-29 WO PCT/US2020/053304 patent/WO2021067291A1/en not_active Ceased
- 2020-09-29 EP EP20792826.8A patent/EP4038185A1/en active Pending
- 2020-09-29 CN CN202080083063.1A patent/CN114929873A/zh active Pending
-
2022
- 2022-03-20 IL IL291509A patent/IL291509A/en unknown
-
2024
- 2024-05-29 JP JP2024087359A patent/JP2024116193A/ja active Pending
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