JP2024079713A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024079713A5 JP2024079713A5 JP2024038710A JP2024038710A JP2024079713A5 JP 2024079713 A5 JP2024079713 A5 JP 2024079713A5 JP 2024038710 A JP2024038710 A JP 2024038710A JP 2024038710 A JP2024038710 A JP 2024038710A JP 2024079713 A5 JP2024079713 A5 JP 2024079713A5
- Authority
- JP
- Japan
- Prior art keywords
- sarna
- seq
- conjugated
- sequence selected
- sense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562150889P | 2015-04-22 | 2015-04-22 | |
| US62/150,889 | 2015-04-22 | ||
| US201562235778P | 2015-10-01 | 2015-10-01 | |
| US62/235,778 | 2015-10-01 | ||
| US201662308521P | 2016-03-15 | 2016-03-15 | |
| US62/308,521 | 2016-03-15 | ||
| JP2020158141A JP6931733B2 (ja) | 2015-04-22 | 2020-09-23 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
| JP2021132267A JP2021192616A (ja) | 2015-04-22 | 2021-08-16 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132267A Division JP2021192616A (ja) | 2015-04-22 | 2021-08-16 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024079713A JP2024079713A (ja) | 2024-06-11 |
| JP2024079713A5 true JP2024079713A5 (OSRAM) | 2024-10-10 |
Family
ID=55948895
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554886A Active JP6768701B2 (ja) | 2015-04-22 | 2016-04-21 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
| JP2020158141A Active JP6931733B2 (ja) | 2015-04-22 | 2020-09-23 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
| JP2021132267A Pending JP2021192616A (ja) | 2015-04-22 | 2021-08-16 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
| JP2024038710A Pending JP2024079713A (ja) | 2015-04-22 | 2024-03-13 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554886A Active JP6768701B2 (ja) | 2015-04-22 | 2016-04-21 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
| JP2020158141A Active JP6931733B2 (ja) | 2015-04-22 | 2020-09-23 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
| JP2021132267A Pending JP2021192616A (ja) | 2015-04-22 | 2021-08-16 | Ｃ／ＥＢＰアルファｓａＲＮＡ組成物および使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10912790B2 (OSRAM) |
| EP (1) | EP3286316A1 (OSRAM) |
| JP (4) | JP6768701B2 (OSRAM) |
| KR (2) | KR102760315B1 (OSRAM) |
| CN (2) | CN114525279A (OSRAM) |
| AU (3) | AU2016251415B9 (OSRAM) |
| SG (1) | SG11201707683YA (OSRAM) |
| WO (1) | WO2016170349A1 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3236835A1 (en) * | 2013-11-22 | 2015-05-28 | Mina Therapeutics Limited | C/ebp alpha short activating rna compositions and methods of use |
| EP3808380A1 (en) * | 2016-12-08 | 2021-04-21 | CureVac AG | Rna for treatment or prophylaxis of a liver disease |
| EP4219715A3 (en) * | 2017-09-08 | 2023-09-06 | MiNA Therapeutics Limited | Stabilized cebpa sarna compositions and methods of use |
| CA3075205A1 (en) | 2017-09-08 | 2019-03-14 | Mina Therapeutics Limited | Stabilized hnf4a sarna compositions and methods of use |
| CN108103108A (zh) * | 2018-01-30 | 2018-06-01 | 上海交通大学医学院附属瑞金医院 | Cebpa基因缺失斑马鱼突变体的制备及其应用 |
| WO2019158720A1 (en) | 2018-02-16 | 2019-08-22 | Mina Therapeutics Limited | C/ebp alpha sarna compositions and methods of use |
| CA3094575A1 (en) * | 2018-04-10 | 2019-10-17 | Ractigen Therapeutics | Novel small activating rna |
| US20210254069A1 (en) * | 2018-06-15 | 2021-08-19 | Mina Therapeutics Limited | Combination therapies comprising c/ebp alpha sarna |
| CN111849968A (zh) | 2019-04-30 | 2020-10-30 | 中美瑞康核酸技术(南通)研究院有限公司 | 寡核苷酸分子及其在急性间歇性卟啉症治疗中的应用 |
| EP4003423A4 (en) * | 2019-07-26 | 2024-03-06 | MiNA Therapeutics Limited | Compositions and methods of using c/ebp alpha sarna |
| CA3148593A1 (en) * | 2019-07-29 | 2021-02-04 | Brightseed, Inc. | Method for improving digestive health |
| AU2020349991A1 (en) * | 2019-09-20 | 2022-04-07 | Ractigen Therapeutics | Nucleic acid molecule for treating immune thrombocytopenia and application thereof |
| EP4069848A4 (en) * | 2019-12-03 | 2024-02-28 | Merck Sharp & Dohme LLC | IN VITRO CELL-BASED POWER DOSING |
| CN115776909A (zh) * | 2020-07-17 | 2023-03-10 | 美国杰龙生物医药公司 | 皮下端粒酶抑制剂组合物及其使用方法 |
| GB202019692D0 (en) * | 2020-12-14 | 2021-01-27 | Apterna Ltd | Aptamer-sirna fusions |
| JP7756166B2 (ja) * | 2020-12-23 | 2025-10-17 | イーライ リリー アンド カンパニー | Ｒｎａ治療薬及びその使用方法 |
| US20240091333A1 (en) | 2020-12-28 | 2024-03-21 | Douglas T. Gjerde | Temperature Stable Nucleic Acid Method for Preparing Vaccines |
| JP2024506882A (ja) * | 2021-02-07 | 2024-02-15 | ラクティゲン セラピューティクス | 化学修飾された低分子活性化ｒｎａ |
| EP4329777A1 (en) | 2021-04-28 | 2024-03-06 | MiNA Therapeutics Limited | Combination therapies comprising c/ebp alpha sarna |
| KR102428121B1 (ko) * | 2021-10-20 | 2022-08-08 | 주식회사 네오나 | 변형된 rt-let7을 유효성분으로 포함하는 간암의 예방 또는 치료를 위한 딜리버리 시스템 |
| CN114306367B (zh) * | 2021-08-27 | 2023-03-28 | 赵小洋 | 一种含有C/EBPα-saRNA的组合物 |
| US12523658B2 (en) * | 2021-08-27 | 2026-01-13 | The Board Of Regents Of The University Of Texas System | Methods for the assessment of risk and treatments for liver cancers and lethal liver disease complications |
| EP4633618A1 (en) * | 2022-12-12 | 2025-10-22 | Regeneron Pharmaceuticals, Inc. | Treatment of type 2 diabetes and/or chronic kidney disease with hepatocyte nuclear factor 4 alpha (hnf4a) agonists |
| WO2024134199A1 (en) * | 2022-12-22 | 2024-06-27 | Mina Therapeutics Limited | Chemically modified sarna compositions and methods of use |
| WO2024165876A2 (en) * | 2023-02-10 | 2024-08-15 | Mina Therapeutics Limited | Compositions and methods of using c/ebp alpha sarna |
| WO2024175887A1 (en) | 2023-02-22 | 2024-08-29 | Mina Therapeutics Limited | Compositions and methods of using c/ebp alpha sarna |
| KR20240138691A (ko) * | 2023-03-13 | 2024-09-20 | 부산대학교 산학협력단 | 류마티스 관절염 진단용 바이오마커 조성물, 이를 이용한 진단용 키트 및 이를 이용한 류마티스 관절염 진단방법 |
| TW202502303A (zh) * | 2023-06-29 | 2025-01-16 | 美商瑞佩爾托利免疫醫藥股份有限公司 | 用於遞送有效載荷之脂質粒子 |
| WO2025052098A1 (en) | 2023-09-08 | 2025-03-13 | Mina Therapeutics Limited | Tmem173 sarna compositions and methods of use |
| CN118480552B (zh) * | 2024-01-18 | 2024-10-01 | 成都先衍生物技术有限公司 | 一种靶向CEBPA基因表达的saRNA及其用途 |
| WO2025224036A1 (en) * | 2024-04-22 | 2025-10-30 | Mina Therapeutics Limited | Chemically modified sarna compositions and methods of use |
| WO2026027887A2 (en) | 2024-08-02 | 2026-02-05 | Mina Therapeutics Limited | Hbg1/2-sarna compositions and methods of use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5192234B2 (ja) * | 2004-08-10 | 2013-05-08 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 化学修飾オリゴヌクレオチド |
| US20110281270A1 (en) | 2008-11-13 | 2011-11-17 | Erasmus University Medical Center Rotterdam | Efficient detection of double mutants of the cebpa gene in acute myeloid leukemia |
| CN102612560B (zh) * | 2009-06-16 | 2017-10-17 | 库尔纳公司 | 通过抑制针对对氧磷酶1(pon1)的天然反义转录物来治疗pon1相关的疾病 |
| GB201010557D0 (en) * | 2010-06-23 | 2010-08-11 | Mina Therapeutics Ltd | RNA molecules and uses thereof |
| AU2011325956B2 (en) * | 2010-11-12 | 2016-07-14 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| KR102039315B1 (ko) | 2011-06-21 | 2019-11-04 | 미나 테라퓨틱스 리미티드 | 알부민 생산 및 세포 증식 |
| DE102011079572B4 (de) * | 2011-07-21 | 2024-12-05 | Endress+Hauser Conducta Gmbh+Co. Kg | Gradiometer zur Bestimmung der elektrischen Leitfähigkeit eines in einem Behältnis enthaltenen Mediums |
| CN104884637A (zh) * | 2012-11-05 | 2015-09-02 | 普隆奈治疗公司 | 利用生物标志物通过bcl2表达的调节治疗癌症的方法 |
| KR20150086294A (ko) * | 2012-11-05 | 2015-07-27 | 프로나이 테라퓨틱스, 인코포레이티드 | 올리고뉴클레오티드 암 치료제의 복용 및 투여 |
| EP2920325A2 (en) * | 2012-11-15 | 2015-09-23 | Bristol-Myers Squibb Company | Biomarkers for predicting clinical response of cancer patients to treatment with immunotherapeutic agent |
| CA3236835A1 (en) * | 2013-11-22 | 2015-05-28 | Mina Therapeutics Limited | C/ebp alpha short activating rna compositions and methods of use |
| CA2991052A1 (en) | 2015-07-02 | 2017-01-05 | City Of Hope | Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof |
-
2016
- 2016-04-21 CN CN202210140475.5A patent/CN114525279A/zh active Pending
- 2016-04-21 JP JP2017554886A patent/JP6768701B2/ja active Active
- 2016-04-21 SG SG11201707683YA patent/SG11201707683YA/en unknown
- 2016-04-21 KR KR1020237037891A patent/KR102760315B1/ko active Active
- 2016-04-21 KR KR1020177030397A patent/KR102599712B1/ko active Active
- 2016-04-21 AU AU2016251415A patent/AU2016251415B9/en active Active
- 2016-04-21 CN CN201680034224.1A patent/CN108291228A/zh active Pending
- 2016-04-21 US US15/568,139 patent/US10912790B2/en active Active
- 2016-04-21 EP EP16721209.1A patent/EP3286316A1/en active Pending
- 2016-04-21 WO PCT/GB2016/051117 patent/WO2016170349A1/en not_active Ceased
-
2019
- 2019-07-31 AU AU2019210578A patent/AU2019210578B2/en active Active
-
2020
- 2020-09-23 JP JP2020158141A patent/JP6931733B2/ja active Active
- 2020-12-09 US US17/117,025 patent/US20210187007A1/en not_active Abandoned
-
2021
- 2021-08-16 JP JP2021132267A patent/JP2021192616A/ja active Pending
-
2022
- 2022-04-08 AU AU2022202355A patent/AU2022202355A1/en not_active Abandoned
-
2024
- 2024-03-13 JP JP2024038710A patent/JP2024079713A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023052363A5 (OSRAM) | ||
| JP2020188756A5 (OSRAM) | ||
| JP2009514877A5 (OSRAM) | ||
| JP2023536974A5 (OSRAM) | ||
| JP2009530319A5 (OSRAM) | ||
| CN113330117A (zh) | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 | |
| JP2016518331A5 (OSRAM) | ||
| JP2009102380A5 (ja) | ｄｓＲＮＡを含む、ウイルス感染又は望ましくない細胞増殖によって媒介されるか又は誘導される病気又は疾患の治療用組成物 | |
| JP2022506503A5 (OSRAM) | ||
| JP2021521796A5 (OSRAM) | ||
| HRP20211410T1 (hr) | Pripravci i postupci za inhibiciju ekspresije gena lpa | |
| JP2021520207A5 (OSRAM) | ||
| JP2010057515A5 (OSRAM) | ||
| ZA200304500B (en) | Method for inhibiting the expression of a target gene and medicament for treating a tumor disease. | |
| JP2018512041A5 (OSRAM) | ||
| JP2013535212A5 (OSRAM) | ||
| JP2018512110A5 (OSRAM) | ||
| JP2017070307A5 (OSRAM) | ||
| Boels et al. | The endothelial glycocalyx as a potential modifier of the hemolytic uremic syndrome | |
| JP2003520811A5 (OSRAM) | ||
| JP2023538284A5 (OSRAM) | ||
| US5756478A (en) | Method for reducing toxicity of D-nucleoside analogs with L-nucleosides | |
| JP2023500661A5 (OSRAM) | ||
| JP2015128433A5 (OSRAM) | ||
| JP2024516356A5 (OSRAM) |