JP2023552368A - Ｙボックス結合タンパク質１阻害剤 - Google Patents

Ｙボックス結合タンパク質１阻害剤 Download PDF

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Publication number
JP2023552368A
JP2023552368A JP2023533819A JP2023533819A JP2023552368A JP 2023552368 A JP2023552368 A JP 2023552368A JP 2023533819 A JP2023533819 A JP 2023533819A JP 2023533819 A JP2023533819 A JP 2023533819A JP 2023552368 A JP2023552368 A JP 2023552368A
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JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
cancer
group
compound
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JP2023533819A
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English (en)
Japanese (ja)
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JP2023552368A5 (https=
Inventor
サンジャイ ブイ． マルホトラ
ダニール テイラー
アーピット ディーライ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health and Science University
Leland Stanford Junior University
Original Assignee
Oregon Health and Science University
Leland Stanford Junior University
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Application filed by Oregon Health and Science University, Leland Stanford Junior University filed Critical Oregon Health and Science University
Publication of JP2023552368A publication Critical patent/JP2023552368A/ja
Publication of JP2023552368A5 publication Critical patent/JP2023552368A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023533819A 2020-12-04 2021-12-03 Ｙボックス結合タンパク質１阻害剤 Pending JP2023552368A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063121674P 2020-12-04 2020-12-04
US63/121,674 2020-12-04
US202163256609P 2021-10-17 2021-10-17
US63/256,609 2021-10-17
PCT/US2021/061906 WO2022120242A1 (en) 2020-12-04 2021-12-03 Y box binding protein 1 inhibitors

Publications (2)

Publication Number Publication Date
JP2023552368A true JP2023552368A (ja) 2023-12-15
JP2023552368A5 JP2023552368A5 (https=) 2024-11-29

Family

ID=81853609

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023533819A Pending JP2023552368A (ja) 2020-12-04 2021-12-03 Ｙボックス結合タンパク質１阻害剤

Country Status (6)

Country Link
US (1) US20240016784A1 (https=)
EP (1) EP4255426A4 (https=)
JP (1) JP2023552368A (https=)
AU (1) AU2021391931A1 (https=)
CA (1) CA3201032A1 (https=)
WO (1) WO2022120242A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4554587A2 (en) * 2022-07-12 2025-05-21 Oregon Health & Science University Enantiomer of azopodophyllotoxin derivative su056

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017151947A1 (en) * 2016-03-02 2017-09-08 George Robert Pettit 4-azapodophylotoxins compounds
WO2019178091A1 (en) * 2018-03-13 2019-09-19 The Board Of Trustees Of The Leland Stanford Junior University Novel n-hydroxyethyl didehydroazapodophyllotoxins as gbp1 inhibitors and methods of overcoming treatment resistance in cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170342086A1 (en) * 2015-02-26 2017-11-30 Ajay Kumar Compounds and methods for the treatment of drug resistance in cancer cells against paclitaxel
CN116761602A (zh) * 2020-12-04 2023-09-15 俄勒冈健康与科学大学 Y盒结合蛋白质1抑制剂

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017151947A1 (en) * 2016-03-02 2017-09-08 George Robert Pettit 4-azapodophylotoxins compounds
WO2019178091A1 (en) * 2018-03-13 2019-09-19 The Board Of Trustees Of The Leland Stanford Junior University Novel n-hydroxyethyl didehydroazapodophyllotoxins as gbp1 inhibitors and methods of overcoming treatment resistance in cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CELL CHEMICAL BIOLOGY, vol. 28, JPN6025046584, 2021, pages 1206 - 1220, ISSN: 0005730778 *

Also Published As

Publication number Publication date
EP4255426A4 (en) 2024-10-23
WO2022120242A1 (en) 2022-06-09
US20240016784A1 (en) 2024-01-18
EP4255426A1 (en) 2023-10-11
AU2021391931A1 (en) 2023-06-29
CA3201032A1 (en) 2022-06-09

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