|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
EP0173552B1
(en)
|
1984-08-24 |
1991-10-09 |
The Upjohn Company |
Recombinant dna compounds and the expression of polypeptides such as tpa
|
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US5436146A
(en)
|
1989-09-07 |
1995-07-25 |
The Trustees Of Princeton University |
Helper-free stocks of recombinant adeno-associated virus vectors
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
EP0590058B1
(en)
|
1991-06-14 |
2003-11-26 |
Genentech, Inc. |
HUMANIZED Heregulin ANTIBODy
|
|
US6268213B1
(en)
|
1992-06-03 |
2001-07-31 |
Richard Jude Samulski |
Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy
|
|
US5478745A
(en)
|
1992-12-04 |
1995-12-26 |
University Of Pittsburgh |
Recombinant viral vector system
|
|
US5869305A
(en)
|
1992-12-04 |
1999-02-09 |
The University Of Pittsburgh |
Recombinant viral vector system
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
WO1996037234A1
(en)
|
1995-05-23 |
1996-11-28 |
Thomas Jefferson University |
Intracellular immunization
|
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
|
US5741683A
(en)
|
1995-06-07 |
1998-04-21 |
The Research Foundation Of State University Of New York |
In vitro packaging of adeno-associated virus DNA
|
|
US6001650A
(en)
|
1995-08-03 |
1999-12-14 |
Avigen, Inc. |
High-efficiency wild-type-free AAV helper functions
|
|
US6207457B1
(en)
*
|
1995-09-08 |
2001-03-27 |
Avigen, Inc. |
Targeted nucleotide sequence delivery and integration system
|
|
US5952221A
(en)
|
1996-03-06 |
1999-09-14 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a first and second nucleic acid sequence
|
|
CA2264482A1
(en)
|
1996-09-06 |
1998-03-12 |
The Trustees Of The University Of Pennsylvania |
An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US20070059302A1
(en)
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
|
DE69829891T2
(de)
|
1997-04-07 |
2005-10-06 |
Genentech, Inc., South San Francisco |
Anti-VEGF Antikörper
|
|
EP1007637B1
(en)
|
1997-04-14 |
2004-06-30 |
Cell Genesys, Inc. |
Methods for increasing the efficiency of recombinant aav product
|
|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
|
US6146874A
(en)
|
1998-05-27 |
2000-11-14 |
University Of Florida |
Method of preparing recombinant adeno-associated virus compositions
|
|
EP1135468B1
(en)
|
1998-11-10 |
2010-01-06 |
University Of North Carolina At Chapel Hill |
Virus vectors and methods of making and administering the same
|
|
US20010034062A1
(en)
|
2000-02-09 |
2001-10-25 |
Scott Koenig |
Antibody gene therapy with adeno-associated viral vectors
|
|
AU6814901A
(en)
|
2000-06-01 |
2001-12-11 |
Univ North Carolina |
Methods and compounds for controlled release of recombinant parvovirus vectors
|
|
CA2448066A1
(en)
|
2001-05-31 |
2002-12-12 |
Chiron Corporation |
Chimeric alphavirus replicon particles
|
|
WO2003023026A1
(en)
|
2001-09-06 |
2003-03-20 |
Alphavax, Inc. |
Alphavirus replicon vector systems
|
|
CN103589692B
(zh)
|
2001-11-13 |
2018-07-24 |
宾夕法尼亚大学托管会 |
检测和/或鉴定腺伴随病毒(aav)序列以及分离所鉴定的新型序列的方法
|
|
DK2359869T3
(en)
|
2001-12-17 |
2019-04-15 |
Univ Pennsylvania |
Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof
|
|
AU2003274397A1
(en)
|
2002-06-05 |
2003-12-22 |
University Of Florida |
Production of pseudotyped recombinant aav virions
|
|
US20040166091A1
(en)
|
2003-02-24 |
2004-08-26 |
Genvec, Inc. |
Materials and methods for treating disorders of the ear
|
|
US7485291B2
(en)
|
2003-06-03 |
2009-02-03 |
Cell Genesys, Inc. |
Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
|
|
WO2005017149A1
(en)
|
2003-06-03 |
2005-02-24 |
Cell Genesys, Inc. |
Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
|
|
EP1668143B1
(en)
|
2003-09-30 |
2013-03-20 |
The Trustees of The University of Pennsylvania |
Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
|
|
US7557197B2
(en)
|
2004-01-28 |
2009-07-07 |
Oregon Health & Science University |
Human soluble neuropilin-1 primary polyadenylation signal and uses thereof
|
|
EP1773401B1
(en)
|
2004-06-21 |
2013-01-02 |
Medtronic, Inc. |
Medical systems and methods for delivering compositions to cells
|
|
EP1765846A4
(en)
|
2004-07-13 |
2010-02-17 |
Cell Genesys Inc |
AAV VECTOR COMPOSITIONS AND ITS USE IN PROCESSES FOR INCREASING IMMUNOGLOBULIN EXPRESSION
|
|
WO2006012414A2
(en)
|
2004-07-20 |
2006-02-02 |
Critical Therapeutics, Inc. |
Novel polyadenylation signal for use in expression vectors
|
|
WO2006073496A2
(en)
*
|
2004-07-30 |
2006-07-13 |
Targeted Genetics Corporation |
Recombinant aav based vaccine methods
|
|
US20060110364A1
(en)
|
2004-08-20 |
2006-05-25 |
Ludwig Institute For Cancer Research |
Vector-mediated delivery of polynucleotides encoding soluble VEGF receptors
|
|
DE23193606T1
(de)
|
2005-04-07 |
2024-02-15 |
The Trustees Of The University Of Pennsylvania |
Verfahren zur erhöhung der funktion eines aav-vektors
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US7588772B2
(en)
|
2006-03-30 |
2009-09-15 |
Board Of Trustees Of The Leland Stamford Junior University |
AAV capsid library and AAV capsid proteins
|
|
US20080248033A1
(en)
|
2006-12-19 |
2008-10-09 |
Genentech, Inc. |
VEGF-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors
|
|
US20090215178A1
(en)
|
2008-02-22 |
2009-08-27 |
Zequn Tang |
Methods to enhance the stability and homogeneity of transgene expression in clonal cell lines
|
|
US8822645B2
(en)
|
2008-07-08 |
2014-09-02 |
Abbvie Inc. |
Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
|
|
EP3543256A1
(en)
|
2009-01-12 |
2019-09-25 |
Cytomx Therapeutics Inc. |
Modified antibody compositions, methods of making and using thereof
|
|
RU2567639C2
(ru)
|
2009-06-17 |
2015-11-10 |
АббВай Биотерапеутикс Инк., |
Антитела против vegf и их применения
|
|
MX2012002651A
(es)
|
2009-09-01 |
2012-05-22 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
AR078651A1
(es)
|
2009-10-15 |
2011-11-23 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
WO2011104307A2
(en)
|
2010-02-25 |
2011-09-01 |
Graffinity Pharmaceuticals Gmbh |
Ligands for antibody purification by affinity chromatography
|
|
GB201004761D0
(en)
|
2010-03-22 |
2010-05-05 |
Medical Res Council |
Method
|
|
WO2011140279A1
(en)
|
2010-05-04 |
2011-11-10 |
Wayne State University |
Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
|
|
KR20130100118A
(ko)
|
2010-08-03 |
2013-09-09 |
아비에 인코포레이티드 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
US8962804B2
(en)
|
2010-10-08 |
2015-02-24 |
City Of Hope |
Meditopes and meditope-binding antibodies and uses thereof
|
|
JP6091435B2
(ja)
|
2011-02-22 |
2017-03-08 |
カリフォルニア インスティチュート オブ テクノロジー |
アデノ随伴ウイルス（ａａｖ）ベクターを用いたタンパク質の送達
|
|
CN102219859B
(zh)
|
2011-05-20 |
2012-09-12 |
烟台荣昌生物工程有限公司 |
拮抗血管新生诱导因子的融合蛋白及其用途
|
|
US20130090375A1
(en)
|
2011-10-06 |
2013-04-11 |
Cornell University |
Virus-mediated delivery of bevacizumab for therapeutic applications
|
|
JP2015527296A
(ja)
|
2012-03-26 |
2015-09-17 |
アメリカ合衆国 |
哺乳動物細胞へのパッケージングされたｒｎａの新規の送達
|
|
US9029510B2
(en)
|
2012-03-30 |
2015-05-12 |
Sorrento Therapeutics, Inc. |
Fully human antibodies that bind to VEGFR2 and methods of use thereof
|
|
TWI698240B
(zh)
|
2012-05-15 |
2020-07-11 |
澳大利亞商艾佛蘭屈澳洲私營有限公司 |
使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
|
|
EP2861068A4
(en)
|
2012-06-01 |
2016-04-13 |
Momenta Pharmaceuticals Inc |
METHODS ASSOCIATED WITH BEVACIZUMAB
|
|
US12024568B2
(en)
|
2012-09-13 |
2024-07-02 |
Cornell University |
Treatment of brain cancers using central nervous system mediated gene transfer of monoclonal antibodies
|
|
SG11201502076SA
(en)
|
2012-09-19 |
2015-04-29 |
Genentech Inc |
Methods and compositions for preventing norleucine misincorporation into proteins
|
|
US9914770B2
(en)
|
2013-04-30 |
2018-03-13 |
Intas Pharmaceuticals Ltd |
Cloning, expression and purification method for the preparation of ranibizumab
|
|
ES2813698T3
(es)
*
|
2013-09-12 |
2021-03-24 |
Biomarin Pharm Inc |
Vectores de AAV que comprenden un gen que codifica el factor VIII
|
|
HUE052676T2
(hu)
*
|
2013-10-11 |
2021-05-28 |
Massachusetts Eye & Ear Infirmary |
Eljárások õsi vírusszekvenciák elõrejelzésére és alkalmazásaik
|
|
CN106414487B
(zh)
|
2014-02-21 |
2021-09-14 |
韦格尼奇有限公司 |
配体结合分子及其用途
|
|
US10307492B2
(en)
|
2014-03-11 |
2019-06-04 |
Wayne State University |
Modified MGLUR6 promoter and methods of use
|
|
EP3119893A1
(en)
|
2014-03-17 |
2017-01-25 |
Taplmmune Inc. |
Nucleic acid molecule vaccine compositions and uses thereof
|
|
KR101844596B1
(ko)
|
2014-03-18 |
2018-04-05 |
한국과학기술원 |
당화 vegf 디코이 수용체 융합 단백질을 포함하는 안질환 치료용 조성물
|
|
CR20160519A
(es)
|
2014-05-13 |
2017-01-27 |
The Trustees Of The Univ Of Pennysylvania |
Composiciones que comprenden avv que expresa constructos de anticuerpos duales y sus usos
|
|
WO2016040441A1
(en)
|
2014-09-09 |
2016-03-17 |
Unum Therapeutics |
Chimeric receptors and uses thereof in immune therapy
|
|
EP3230452B1
(en)
|
2014-12-12 |
2025-06-11 |
The Broad Institute, Inc. |
Dead guides for crispr transcription factors
|
|
US10946094B2
(en)
|
2015-02-24 |
2021-03-16 |
Cornell University |
Adenoassociated viral mediated persistant anti-VEGF therapy for ovarian cancer
|
|
EP4378487A3
(en)
|
2015-06-23 |
2024-09-04 |
The Children's Hospital of Philadelphia |
Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues
|
|
EP3344294A4
(en)
|
2015-08-31 |
2019-03-20 |
The Trustees Of The University Of Pennsylvania |
CHIMERIC AAV ANTI-VEGF FOR THE TREATMENT OF CANCER IN DOGS
|
|
WO2017050825A1
(en)
|
2015-09-21 |
2017-03-30 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
A method for quantifying bevacizumab
|
|
GB201518979D0
(en)
|
2015-10-27 |
2015-12-09 |
Univ Leuven Kath |
Treatment of hepatic steatosis related oligo-ovulation
|
|
US11135313B2
(en)
|
2015-10-28 |
2021-10-05 |
The Trustees Of The University Of Pennsylvania |
Intrathecal administration of adeno-associated-viral vectors for gene therapy
|
|
CA3007476A1
(en)
|
2015-12-11 |
2017-06-15 |
Massachusetts Eye And Ear Infirmary |
Materials and methods for delivering nucleic acids to cochlear and vestibular cells
|
|
IL290457B2
(en)
|
2015-12-30 |
2025-02-01 |
Kodiak Sciences Inc |
Antibodies and their conjugates
|
|
WO2017147265A1
(en)
|
2016-02-23 |
2017-08-31 |
Salk Institute For Biological Studies |
High throughput assay for measuring adenovirus replication kinetics
|
|
IL262207B2
(en)
|
2016-04-15 |
2026-01-01 |
Univ Pennsylvania |
Preparations for the treatment of wet age-related macular degeneration
|
|
JP2019515027A
(ja)
|
2016-04-15 |
2019-06-06 |
レジェンクスバイオ インコーポレーテッド |
翻訳後修飾された完全ヒト抗ＶＥＧＦ Ｆａｂを用いる眼疾患の治療
|
|
CN117531025A
(zh)
|
2016-06-16 |
2024-02-09 |
阿德夫拉姆生物技术股份有限公司 |
使用aav2变体和阿柏西普治疗amd
|
|
PL3472317T3
(pl)
|
2016-06-16 |
2022-08-08 |
Adverum Biotechnologies, Inc. |
Kompozycje i sposoby zmniejszania neowaskularyzacji oka
|
|
WO2018039375A1
(en)
*
|
2016-08-23 |
2018-03-01 |
Akouos, Inc. |
Compositions and methods for treating non-age-associated hearing impairment in a human subject
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
CA3076905A1
(en)
|
2017-09-27 |
2019-04-04 |
The Johns Hopkins University |
Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab
|
|
KR20200067195A
(ko)
|
2017-10-18 |
2020-06-11 |
리젠엑스바이오 인크. |
완전-인간 번역후 변형된 항체 치료제
|
|
US20240335560A1
(en)
|
2017-11-27 |
2024-10-10 |
4D Molecular Therapeutics Inc |
Adeno-associated virus variant capsids and use for inhibiting angiogenesis
|
|
US11766489B2
(en)
|
2017-11-27 |
2023-09-26 |
4D Molecular Therapeutics, Inc. |
Adeno-associated virus variant capsids and use for inhibiting angiogenesis
|
|
CA3084733A1
(en)
|
2017-12-14 |
2019-06-20 |
Crispr Therapeutics Ag |
Materials and methods for treatment of autosomal dominant cone-rod dystrophy
|
|
CA3086045A1
(en)
*
|
2017-12-19 |
2019-06-27 |
Akouos, Inc. |
Aav-mediated delivery of therapeutic antibodies to the inner ear
|
|
US12558434B2
(en)
*
|
2018-02-20 |
2026-02-24 |
The Trustees Of The University Of Pennsylvania |
Compositions for treatment of wet age-related macular degeneration
|
|
CN113853437A
(zh)
*
|
2018-11-07 |
2021-12-28 |
阿库斯股份有限公司 |
腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基因缺陷/表达蛋白质的用途
|
|
EP4667578A3
(en)
|
2019-04-03 |
2026-04-01 |
REGENXBIO Inc. |
Gene therapy for eye pathologies
|
|
US20220195462A1
(en)
|
2019-04-24 |
2022-06-23 |
Regenxbio Inc. |
Fully-human post-translationally modified antibody therapeutics
|
|
CA3149401A1
(en)
|
2019-08-26 |
2021-03-04 |
Stephen Joseph Pakola |
Treatment of diabetic retinopathy with fully-human post-translationally modified anti-vegf fab
|
|
WO2021046245A1
(en)
|
2019-09-04 |
2021-03-11 |
University Of Massachusetts |
Adeno-associated virus vector platform for delivery of kh902 (conbercept) and uses thereof
|
|
WO2021071835A1
(en)
|
2019-10-07 |
2021-04-15 |
Regenxbio Inc. |
Adeno-associated virus vector pharmaceutical composition and methods
|
|
JP2022552375A
(ja)
|
2019-10-15 |
2022-12-15 |
コーネル・ユニバーシティー |
遺伝子治療発現カセットからの発現レベルを調節するための方法
|
|
EP4054653A4
(en)
|
2019-11-04 |
2023-11-29 |
Decibel Therapeutics, Inc. |
PROMOTERS OF COCHLEAR EXTERNAL HAIR CELLS AND THEIR USES
|
|
CN115335529B
(zh)
|
2019-11-26 |
2026-07-03 |
马萨诸塞大学 |
用于递送kh902(康柏西普)的重组腺相关病毒及其用途
|
|
CN116096900A
(zh)
|
2020-05-13 |
2023-05-09 |
阿库斯股份有限公司 |
用于治疗gjb2相关听力损失的组合物和方法
|
|
WO2021255590A1
(en)
|
2020-06-16 |
2021-12-23 |
Intas Pharmaceuticals Ltd. |
An anti-vegf scfv adeno-associated virus (aav) vector and uses thereof
|
|
WO2021255589A1
(en)
|
2020-06-16 |
2021-12-23 |
Intas Pharmaceuticals Ltd. |
An anti-vegf scfab adeno-associated virus (aav) vector and uses thereof
|
|
AU2021313839A1
(en)
|
2020-07-21 |
2023-03-23 |
FTGEN Corp |
Composition and method for treating eye diseases
|
|
US20230340529A1
(en)
|
2020-09-03 |
2023-10-26 |
University Of Massachusetts |
Adeno-associated virus for delivery of kh902 (conbercept) and uses thereof
|
|
EP4225381A1
(en)
|
2020-10-07 |
2023-08-16 |
RegenxBio Inc. |
Formulations for suprachoroidal administration such as formulations with aggregate formation
|
|
TW202228648A
(zh)
|
2020-10-07 |
2022-08-01 |
美商銳進科斯生物股份有限公司 |
諸如高黏度調配物之用於脈絡膜上投與之調配物
|
|
TW202228646A
(zh)
|
2020-10-07 |
2022-08-01 |
美商銳進科斯生物股份有限公司 |
諸如凝膠調配物之用於脈絡膜上投與之調配物
|
|
IL303317A
(en)
|
2020-12-01 |
2023-07-01 |
Akouos Inc |
ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA
|
|
CN115427561B
(zh)
|
2021-03-09 |
2024-06-04 |
辉大(上海)生物科技有限公司 |
工程化CRISPR/Cas13系统及其用途
|
|
MX2023013394A
(es)
|
2021-05-13 |
2023-12-14 |
Akouos Inc |
Composiciones de suministro de terapia genica y metodos para tratar perdida auditiva.
|
|
EP4368203A4
(en)
|
2021-07-05 |
2025-09-24 |
Wuhan Neurophth Biotechnology Ltd Company |
CONSTRUCTION AND USE OF ANTI-VEGF ANTIBODIES IN AN IN VIVO EXPRESSION SYSTEM
|
|
WO2023283962A1
(en)
|
2021-07-16 |
2023-01-19 |
Huigene Therapeutics Co., Ltd. |
Modified aav capsid for gene therapy and methods thereof
|
|
CA3228501A1
(en)
|
2021-08-09 |
2023-02-16 |
Sicong DONG |
Bispecific fusion polypeptide and application thereof
|
|
AR128422A1
(es)
|
2022-02-02 |
2024-05-08 |
Akouos Inc |
Construcciones de anticuerpos anti-vegf y métodos relacionados para el tratamiento de los síntomas asociados al schwannoma vestibular
|
|
WO2023155918A1
(zh)
|
2022-02-21 |
2023-08-24 |
上海瑞宏迪医药有限公司 |
Vegf结合分子及其医药用途
|
|
CN117304307A
(zh)
|
2022-06-27 |
2023-12-29 |
上海鼎新基因科技有限公司 |
一种治疗新生血管相关眼底疾病的aav药物
|
|
CN118853712A
(zh)
|
2023-04-28 |
2024-10-29 |
成都弘基生物科技有限公司 |
编码抗vegf蛋白的核酸、多核苷酸表达盒及重组腺相关病毒
|