JP2023548145A - 眼の適応症に対するベクター化ｔｎｆ－アルファアンタゴニスト - Google Patents

眼の適応症に対するベクター化ｔｎｆ－アルファアンタゴニスト Download PDF

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JP2023548145A
JP2023548145A JP2023526231A JP2023526231A JP2023548145A JP 2023548145 A JP2023548145 A JP 2023548145A JP 2023526231 A JP2023526231 A JP 2023526231A JP 2023526231 A JP2023526231 A JP 2023526231A JP 2023548145 A JP2023548145 A JP 2023548145A
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serotype
aav
tnfα
cells
seq
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JP2023548145A5 (https=
JPWO2022094295A5 (https=
Inventor
ワン，シュー
マクドゥーガルド，デヴィン
ブルーダー，ジョセフ
リウ，イェ
ダノス，オリビエ
チャオ，チャンピング
リー，ウェイ－ファ
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リジェネックスバイオ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C12N15/09—Recombinant DNA-technology
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Peptides Or Proteins (AREA)
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JP2023526231A 2020-10-29 2021-10-29 眼の適応症に対するベクター化ｔｎｆ－アルファアンタゴニスト Pending JP2023548145A (ja)

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Application Number Priority Date Filing Date Title
US202063107415P 2020-10-29 2020-10-29
US63/107,415 2020-10-29
PCT/US2021/057380 WO2022094295A1 (en) 2020-10-29 2021-10-29 Vectorized tnf-alpha antagonists for ocular indications

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JP2023548145A true JP2023548145A (ja) 2023-11-15
JP2023548145A5 JP2023548145A5 (https=) 2024-11-07
JPWO2022094295A5 JPWO2022094295A5 (https=) 2024-11-07

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US (1) US20240384292A1 (https=)
EP (1) EP4237453A1 (https=)
JP (1) JP2023548145A (https=)
KR (1) KR20230098176A (https=)
CN (1) CN116457373A (https=)
AU (1) AU2021369833A1 (https=)
CA (1) CA3196964A1 (https=)
IL (1) IL302282A (https=)
MX (1) MX2023004843A (https=)
WO (1) WO2022094295A1 (https=)

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