JP2023545707A - スルホグルコサミンスルホヒドロラーゼ酵素を含む融合タンパク質及びその方法 - Google Patents
スルホグルコサミンスルホヒドロラーゼ酵素を含む融合タンパク質及びその方法 Download PDFInfo
- Publication number
- JP2023545707A JP2023545707A JP2023521078A JP2023521078A JP2023545707A JP 2023545707 A JP2023545707 A JP 2023545707A JP 2023521078 A JP2023521078 A JP 2023521078A JP 2023521078 A JP2023521078 A JP 2023521078A JP 2023545707 A JP2023545707 A JP 2023545707A
- Authority
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- Japan
- Prior art keywords
- polypeptide
- amino acid
- sgsh
- acid sequence
- identity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y310/00—Hydrolases acting on sulfur-nitrogen bonds (3.10)
- C12Y310/01—Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y310/00—Hydrolases acting on sulfur-nitrogen bonds (3.10)
- C12Y310/01—Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
- C12Y310/01001—N-Sulfoglucosamine sulfohydrolase (3.10.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2026053672A JP2026095522A (ja) | 2020-10-14 | 2026-03-27 | スルホグルコサミンスルホヒドロラーゼ酵素を含む融合タンパク質及びその方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063091800P | 2020-10-14 | 2020-10-14 | |
| US63/091,800 | 2020-10-14 | ||
| PCT/US2021/054860 WO2022081765A1 (en) | 2020-10-14 | 2021-10-13 | Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2026053672A Division JP2026095522A (ja) | 2020-10-14 | 2026-03-27 | スルホグルコサミンスルホヒドロラーゼ酵素を含む融合タンパク質及びその方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023545707A true JP2023545707A (ja) | 2023-10-31 |
| JP2023545707A5 JP2023545707A5 (enExample) | 2024-10-17 |
Family
ID=78725609
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023521078A Pending JP2023545707A (ja) | 2020-10-14 | 2021-10-13 | スルホグルコサミンスルホヒドロラーゼ酵素を含む融合タンパク質及びその方法 |
| JP2026053672A Pending JP2026095522A (ja) | 2020-10-14 | 2026-03-27 | スルホグルコサミンスルホヒドロラーゼ酵素を含む融合タンパク質及びその方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2026053672A Pending JP2026095522A (ja) | 2020-10-14 | 2026-03-27 | スルホグルコサミンスルホヒドロラーゼ酵素を含む融合タンパク質及びその方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11884944B2 (enExample) |
| EP (1) | EP4229192A1 (enExample) |
| JP (2) | JP2023545707A (enExample) |
| KR (1) | KR20230086703A (enExample) |
| CN (1) | CN116916947A (enExample) |
| AR (1) | AR123788A1 (enExample) |
| AU (2) | AU2021362209B2 (enExample) |
| CA (1) | CA3197506A1 (enExample) |
| CL (1) | CL2023001034A1 (enExample) |
| CO (1) | CO2023005260A2 (enExample) |
| CR (1) | CR20230178A (enExample) |
| EC (1) | ECSP23035251A (enExample) |
| IL (1) | IL302029A (enExample) |
| MA (1) | MA71661A (enExample) |
| MX (1) | MX2023004335A (enExample) |
| PE (1) | PE20231931A1 (enExample) |
| WO (1) | WO2022081765A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS63818B1 (sr) | 2017-02-17 | 2023-01-31 | Denali Therapeutics Inc | Konstruisani polipeptidi za vezivanje za receptor transferina |
| BR112020005271A2 (pt) | 2017-10-02 | 2020-09-15 | Denali Therapeutics Inc. | proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica |
| JP7543290B2 (ja) | 2019-02-20 | 2024-09-02 | デナリ セラピューティクス インコーポレイテッド | 抗ｔｒｅｍ２抗体及びその使用方法 |
| AU2020252554B2 (en) | 2019-04-03 | 2026-05-28 | Denali Therapeutics Inc. | Formulations of protein molecules comprising iduronate 2-sulfatase |
| BR112022012230A2 (pt) | 2019-12-23 | 2022-08-30 | Denali Therapeutics Inc | Variantes de progranulina |
| IL311003A (en) | 2021-08-25 | 2024-04-01 | Denali Therapeutics Inc | Anti-2HER antibodies and methods of using them |
| TW202542190A (zh) * | 2023-12-20 | 2025-11-01 | 美商戴納立製藥公司 | 包含酸性α—葡萄糖苷酶之融合蛋白及其方法 |
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| WO2018124121A1 (ja) * | 2016-12-26 | 2018-07-05 | Ｊｃｒファーマ株式会社 | 血液脳関門を通過する新規な抗ヒトトランスフェリン受容体抗体 |
| WO2019070577A1 (en) * | 2017-10-02 | 2019-04-11 | Denali Therapeutics Inc. | FUSION PROTEINS COMPRISING SUBSTITUTE ENZYM THERAPY ENZYMES |
| WO2019226973A1 (en) * | 2018-05-25 | 2019-11-28 | Alector Llc | Anti-sirpa antibodies and methods of use thereof |
| WO2020047374A1 (en) * | 2018-08-31 | 2020-03-05 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
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| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
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| EP3840781A1 (en) | 2018-08-22 | 2021-06-30 | Denali Therapeutics Inc. | Anti-her2 polypeptides and methods of use thereof |
| AU2020252554B2 (en) | 2019-04-03 | 2026-05-28 | Denali Therapeutics Inc. | Formulations of protein molecules comprising iduronate 2-sulfatase |
| BR112022012230A2 (pt) | 2019-12-23 | 2022-08-30 | Denali Therapeutics Inc | Variantes de progranulina |
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-
2021
- 2021-10-13 CR CR20230178A patent/CR20230178A/es unknown
- 2021-10-13 EP EP21811560.8A patent/EP4229192A1/en active Pending
- 2021-10-13 KR KR1020237014440A patent/KR20230086703A/ko active Pending
- 2021-10-13 MX MX2023004335A patent/MX2023004335A/es unknown
- 2021-10-13 WO PCT/US2021/054860 patent/WO2022081765A1/en not_active Ceased
- 2021-10-13 AU AU2021362209A patent/AU2021362209B2/en active Active
- 2021-10-13 CN CN202180069692.3A patent/CN116916947A/zh active Pending
- 2021-10-13 PE PE2023001396A patent/PE20231931A1/es unknown
- 2021-10-13 CA CA3197506A patent/CA3197506A1/en active Pending
- 2021-10-13 JP JP2023521078A patent/JP2023545707A/ja active Pending
- 2021-10-13 IL IL302029A patent/IL302029A/en unknown
- 2021-10-13 MA MA71661A patent/MA71661A/fr unknown
- 2021-10-14 AR ARP210102838A patent/AR123788A1/es unknown
-
2022
- 2022-06-30 US US17/855,543 patent/US11884944B2/en active Active
-
2023
- 2023-04-11 CL CL2023001034A patent/CL2023001034A1/es unknown
- 2023-04-25 CO CONC2023/0005260A patent/CO2023005260A2/es unknown
- 2023-05-12 EC ECSENADI202335251A patent/ECSP23035251A/es unknown
-
2024
- 2024-01-12 US US18/411,592 patent/US20240150736A1/en active Pending
-
2026
- 2026-03-27 JP JP2026053672A patent/JP2026095522A/ja active Pending
- 2026-05-11 AU AU2026203601A patent/AU2026203601A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018124121A1 (ja) * | 2016-12-26 | 2018-07-05 | Ｊｃｒファーマ株式会社 | 血液脳関門を通過する新規な抗ヒトトランスフェリン受容体抗体 |
| WO2019070577A1 (en) * | 2017-10-02 | 2019-04-11 | Denali Therapeutics Inc. | FUSION PROTEINS COMPRISING SUBSTITUTE ENZYM THERAPY ENZYMES |
| WO2019226973A1 (en) * | 2018-05-25 | 2019-11-28 | Alector Llc | Anti-sirpa antibodies and methods of use thereof |
| WO2020047374A1 (en) * | 2018-08-31 | 2020-03-05 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
Non-Patent Citations (3)
| Title |
|---|
| CLINICAL PHARMACOLOGY & THERAPEUTICS, vol. 97, no. 4, JPN6025040629, 2015, pages 347 - 361, ISSN: 0005699587 * |
| JOURNAL OF EXPERIMENATL MEDICINE, vol. Vol.217, No.9, e20200785, JPN6025040630, June 2020 (2020-06-01), pages 1 - 19, ISSN: 0005699585 * |
| MOLECULAR PHARMACEUTICS, vol. 15, JPN6025040631, 2018, pages 602 - 608, ISSN: 0005699586 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CL2023001034A1 (es) | 2023-10-06 |
| AU2026203601A1 (en) | 2026-05-28 |
| KR20230086703A (ko) | 2023-06-15 |
| EP4229192A1 (en) | 2023-08-23 |
| US20240150736A1 (en) | 2024-05-09 |
| MA71661A (fr) | 2025-05-30 |
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