JP2023539871A - グリア芽細胞腫を処置するための方法および組成物 - Google Patents

グリア芽細胞腫を処置するための方法および組成物 Download PDF

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JP2023539871A
JP2023539871A JP2023513567A JP2023513567A JP2023539871A JP 2023539871 A JP2023539871 A JP 2023539871A JP 2023513567 A JP2023513567 A JP 2023513567A JP 2023513567 A JP2023513567 A JP 2023513567A JP 2023539871 A JP2023539871 A JP 2023539871A
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イボンヌ ユ-シュアン チェン
アンドリュー ジェイ. フー
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JP2023513567A 2020-08-26 2021-08-25 グリア芽細胞腫を処置するための方法および組成物 Pending JP2023539871A (ja)

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Application Number Priority Date Filing Date Title
US202063070550P 2020-08-26 2020-08-26
US63/070,550 2020-08-26
US202163171187P 2021-04-06 2021-04-06
US63/171,187 2021-04-06
US202163218761P 2021-07-06 2021-07-06
US63/218,761 2021-07-06
PCT/US2021/047604 WO2022046938A1 (en) 2020-08-26 2021-08-25 Methods and compositions for treating glioblastoma

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023539870A (ja) * 2020-08-26 2023-09-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア グリア芽細胞腫を処置するための方法および組成物

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
EP3568466A4 (en) 2017-01-10 2020-07-15 The General Hospital Corporation TARGETED T CELLS WITH CYTOTOXICITY TO IMMUNOSUPPRESSIVE CELLS
US12378297B2 (en) 2017-04-14 2025-08-05 The General Hospital Corporation Chimeric antigen receptor T cells targeting the tumor microenvironment
WO2019157533A1 (en) * 2018-02-12 2019-08-15 The General Hospital Corporation Chimeric antigen receptors targeting the tumor microenvironment
CN116555204B (zh) * 2023-07-04 2023-09-12 苏州驾玉生物医药有限公司 一种性能提升的突变荧光素酶及其应用
WO2025096603A1 (en) * 2023-10-30 2025-05-08 City Of Hope Targeted chimeric antigen receptor modified t cells for treatment of il13ralpha2 positive malignancies
WO2025193475A1 (en) * 2024-03-14 2025-09-18 The Regents Of The University Of California Enhancing immune cell innate and adaptive responses

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015513394A (ja) * 2012-02-13 2015-05-14 シアトル チルドレンズ ホスピタル ドゥーイング ビジネ 二重特異性キメラ抗原受容体およびその治療的使用
JP2019500012A (ja) * 2015-10-30 2019-01-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア トランスフォーミング増殖因子ベータ応答性ポリペプチド及びその使用方法
JP2019511244A (ja) * 2016-02-02 2019-04-25 エコール ポリテクニーク フェデラル ド ローザンヌ (エペエフエル) 操作された抗原提示細胞及びそれらの使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884603B2 (en) * 1998-04-03 2005-04-26 The Penn State Research Foundation Nucleic acids encoding IL13 mutants
EP2331566B1 (en) * 2008-08-26 2015-10-07 City of Hope Method and compositions for enhanced anti-tumor effector functioning of t cells
JP2017537622A (ja) * 2014-12-02 2017-12-21 ロジャー・ウィリアムズ・ホスピタル がんを治療するための方法及び組成物
JP6821688B2 (ja) * 2015-10-09 2021-01-27 ミルテニー・バイオテク・テクノロジー・インコーポレイテッドMiltenyi Biotec Technology, Inc. キメラ抗原受容体および使用方法
US20180100016A1 (en) * 2016-12-22 2018-04-12 Xiaotong Song Use of car-modified human natural killer cells to treat cancer
BR112019017256A2 (pt) * 2017-02-20 2020-04-14 Dragonfly Therapeutics Inc proteínas de ligação gd2, nkg2d e cd16
CA3095757A1 (en) * 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating glioblastomas
JP2023539871A (ja) * 2020-08-26 2023-09-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア グリア芽細胞腫を処置するための方法および組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015513394A (ja) * 2012-02-13 2015-05-14 シアトル チルドレンズ ホスピタル ドゥーイング ビジネ 二重特異性キメラ抗原受容体およびその治療的使用
JP2019500012A (ja) * 2015-10-30 2019-01-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア トランスフォーミング増殖因子ベータ応答性ポリペプチド及びその使用方法
JP2019511244A (ja) * 2016-02-02 2019-04-25 エコール ポリテクニーク フェデラル ド ローザンヌ (エペエフエル) 操作された抗原提示細胞及びそれらの使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BURGER, MICHAEL C. ET AL., FRONTIERS IN IMMUNOLOGY, vol. 10, JPN6025030872, 2019, ISSN: 0005651758 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023539870A (ja) * 2020-08-26 2023-09-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア グリア芽細胞腫を処置するための方法および組成物

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CN116348482A (zh) 2023-06-27
EP4204443A4 (en) 2025-02-26
CN116528889A8 (zh) 2023-10-31
CA3193009A1 (en) 2022-03-03
WO2022046935A3 (en) 2022-04-07
CA3193006A1 (en) 2022-03-03
EP4203990A2 (en) 2023-07-05
WO2022046938A1 (en) 2022-03-03
JP2023539870A (ja) 2023-09-20
CN116528889A (zh) 2023-08-01
US20230322894A1 (en) 2023-10-12
WO2022046935A2 (en) 2022-03-03
US20230364139A1 (en) 2023-11-16
EP4203990A4 (en) 2025-10-01
EP4204443A1 (en) 2023-07-05

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