JP2023539584A5 - - Google Patents
Info
- Publication number
- JP2023539584A5 JP2023539584A5 JP2023512797A JP2023512797A JP2023539584A5 JP 2023539584 A5 JP2023539584 A5 JP 2023539584A5 JP 2023512797 A JP2023512797 A JP 2023512797A JP 2023512797 A JP2023512797 A JP 2023512797A JP 2023539584 A5 JP2023539584 A5 JP 2023539584A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- group
- general formula
- pharmaceutically acceptable
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025280769A JP2026053592A (ja) | 2020-09-01 | 2025-12-24 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010905693 | 2020-09-01 | ||
| CN202010905693.4 | 2020-09-01 | ||
| CN202010984336 | 2020-09-18 | ||
| CN202010984336.1 | 2020-09-18 | ||
| CN202011124085.6 | 2020-10-20 | ||
| CN202011124085 | 2020-10-20 | ||
| CN202011253077 | 2020-11-11 | ||
| CN202011253077.1 | 2020-11-11 | ||
| CN202011407911 | 2020-12-04 | ||
| CN202011407911.8 | 2020-12-04 | ||
| CN202011627733 | 2020-12-31 | ||
| CN202011627733.X | 2020-12-31 | ||
| PCT/CN2021/115915 WO2022007979A1 (zh) | 2020-09-01 | 2021-09-01 | 稠合咪唑类衍生物、其制备方法及其在医药上的应用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025280769A Division JP2026053592A (ja) | 2020-09-01 | 2025-12-24 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023539584A JP2023539584A (ja) | 2023-09-15 |
| JP2023539584A5 true JP2023539584A5 (cg-RX-API-DMAC10.html) | 2024-06-11 |
| JP7812052B2 JP7812052B2 (ja) | 2026-02-09 |
Family
ID=79552285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023512797A Active JP7812052B2 (ja) | 2020-09-01 | 2021-09-01 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
| JP2025280769A Pending JP2026053592A (ja) | 2020-09-01 | 2025-12-24 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025280769A Pending JP2026053592A (ja) | 2020-09-01 | 2025-12-24 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
Country Status (15)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| WO2021219019A1 (en) * | 2020-04-29 | 2021-11-04 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| PH12022553313A1 (en) * | 2020-06-04 | 2023-04-12 | Hangzhou Sciwind Biosciences Co Ltd | Five-membered heteroaromatic imidazole compound and use thereof |
| PE20231181A1 (es) | 2020-08-06 | 2023-08-11 | Gasherbrum Bio Inc | Agonistas del glp-1 heterociclicos |
| JP2023538949A (ja) | 2020-08-28 | 2023-09-12 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| JP7812052B2 (ja) | 2020-09-01 | 2026-02-09 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
| US20240252492A1 (en) * | 2021-01-28 | 2024-08-01 | Carmot Therapeutics ,Inc. | Gpcr receptor agonists, pharmaceutical compositions comprising the same, and methods for their use |
| TWI843104B (zh) | 2021-05-20 | 2024-05-21 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
| US20240360109A1 (en) * | 2021-08-04 | 2024-10-31 | Shanghai Hansoh Biomedical Co., Ltd. | Cycloalkene derivative regulator, preparation method therefor, and application thereof |
| CN116419923B (zh) * | 2021-08-24 | 2024-09-06 | 东宝紫星(杭州)生物医药有限公司 | 咪唑并环类化合物及其应用 |
| KR20240053617A (ko) | 2021-08-30 | 2024-04-24 | 민드랭크 에이아이 리미티드 | Glp1r 작용제로서의 신규 아릴 에테르 치환 헤테로시클릭 화합물 |
| SI4408840T1 (sl) | 2021-09-27 | 2025-12-31 | Terns Pharmaceuticals, Inc. | Benzimidazolne karboksilne kisline kot agonisti GLP-1R |
| US20250236627A1 (en) | 2021-10-05 | 2025-07-24 | Astrazeneca Ab | Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators |
| WO2023057429A1 (en) | 2021-10-05 | 2023-04-13 | Astrazeneca Ab | Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators |
| WO2023057427A1 (en) | 2021-10-05 | 2023-04-13 | Astrazeneca Ab | Certain 2,5-diazabicyclo[4.2.0]octanes as glp-1 receptor modulators |
| US12024507B2 (en) | 2021-10-25 | 2024-07-02 | Terns Pharmaceuticals, Inc. | Compounds as GLP-1R agonists |
| US20250066338A1 (en) | 2021-12-16 | 2025-02-27 | Astrazeneca Ab | Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators |
| US20250042882A1 (en) | 2021-12-16 | 2025-02-06 | Astrazeneca Ab | Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators |
| KR20240125004A (ko) * | 2021-12-23 | 2024-08-19 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | Glp-1 수용체 작용제의 결정 형태 및 이의 제조방법 |
| DK4455141T3 (da) * | 2021-12-23 | 2026-04-27 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Farmaceutisk acceptabelt salt og krystallinsk form af en glp-1-receptoragonist til behandling af diabetes |
| AU2023224854A1 (en) | 2022-02-23 | 2024-10-03 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| CN119730852A (zh) * | 2022-06-23 | 2025-03-28 | 西藏海思科制药有限公司 | 一种五并五元环衍生物的药物组合物及其在医药上的应用 |
| WO2024102625A1 (en) | 2022-11-11 | 2024-05-16 | Eli Lilly And Company | Glucagon-like peptide 1 receptor agonists |
| CR20250178A (es) | 2022-11-16 | 2025-06-06 | Lilly Co Eli | Agonistas del receptor del péptido-1 similar al glucagón |
| JP2026501285A (ja) * | 2022-12-22 | 2026-01-14 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| CN116102555A (zh) * | 2022-12-23 | 2023-05-12 | 华中药业股份有限公司 | 咪唑并芳杂基类衍生物及其应用 |
| KR20250139383A (ko) * | 2023-02-02 | 2025-09-23 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 시클로알켄계 화합물의 염, 결정형 및 이의 제조 방법과 응용 |
| PE20252787A1 (es) | 2023-04-07 | 2025-12-22 | Terns Pharmaceuticals Inc | Combinacion que comprende un agonista de thr-beta y un agonista de glp-1r para su uso en el tratamiento de un trastorno hepatico o una enfermedad cardiometabolica |
| WO2025007843A1 (zh) * | 2023-07-03 | 2025-01-09 | 德睿智药(苏州)新药研发有限公司 | 作为glp1r激动剂的新型前药化合物或稠环化合物 |
| EP4777197A2 (en) | 2023-09-14 | 2026-07-22 | Ascletis Pharma (China) Co., Limited | Glp-1r agonist and therapeutic method thereof |
| WO2025109387A1 (en) | 2023-11-24 | 2025-05-30 | Ascletis Pharma (China) Co., Limited | Glp-1r agonist and therapeutic method thereof |
| AU2025207498A1 (en) | 2024-01-09 | 2026-07-09 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Glp-1r agonist pharmaceutical composition and use thereof |
| TW202545936A (zh) | 2024-02-01 | 2025-12-01 | 大陸商上海森輝醫藥有限公司 | 製備苯并二氧雜環或其鹽方法 |
| TW202600132A (zh) | 2024-03-08 | 2026-01-01 | 美商安尼波那生物公司 | 用於治療肥胖症及提高減重之方法 |
| WO2025252201A1 (zh) * | 2024-06-07 | 2025-12-11 | 江苏豪森药业集团有限公司 | 一种环烯类衍生物的制备方法 |
| WO2026017039A1 (zh) * | 2024-07-15 | 2026-01-22 | 成都地奥九泓制药厂 | Glp-1受体激动剂化合物的盐、晶型、制备方法及其药物组合物和用途 |
| WO2026092583A1 (en) | 2024-10-30 | 2026-05-07 | Ascletis Pharma (China) Co., Limited | Thr-beta modulators, alone or in combination with glp-1r\gipr\gcgr modulators for the treatment of metabolic diseases and alopecia areata diseases |
| WO2026092581A1 (en) | 2024-10-30 | 2026-05-07 | Ascletis Pharma (China) Co., Limited | Thyroid hormone receptor beta modulator alone or in combination with a modulator of glp-1r, gipr or gcgr, for use in the treatment of obesity or overweight or for treating alopecia areata |
| WO2026092580A1 (en) | 2024-10-30 | 2026-05-07 | Ascletis Pharma (China) Co., Limited | Glp-1r\gipr\gcgr modulator in combination with thr-beta modulator for treatment of metabolic diseases |
| WO2026119119A1 (zh) * | 2024-12-02 | 2026-06-11 | 江苏恒瑞医药股份有限公司 | 氧杂环丁烷衍生物或其盐的制备方法及用途 |
| WO2026158424A1 (zh) * | 2025-01-24 | 2026-07-30 | 江苏恒瑞医药股份有限公司 | Glp-1受体激动剂的医药用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA80131C2 (en) | 2002-05-28 | 2007-08-27 | Dimensional Pharm Inc | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
| EA018225B1 (ru) | 2008-03-07 | 2013-06-28 | Транстек Фарма, Инк. | Соединения оксадиазоантрацена для лечения диабета |
| MX2011010347A (es) | 2009-03-30 | 2011-11-29 | Transtech Pharma Inc | Derivados sustituidos de azoantraceno, composiciones farmaceuticas y metodos de uso de los mismos. |
| JP5690839B2 (ja) * | 2009-12-04 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のベンゾイミダゾール阻害薬 |
| JP6736816B2 (ja) | 2014-12-08 | 2020-08-05 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | ピリジンカルボキサミド誘導体、それらの製造方法およびそれらの医薬用途 |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| WO2018109607A1 (en) | 2016-12-16 | 2018-06-21 | Pfizer Inc. | Glp-1 receptor agonists and uses thereof |
| CA3045644C (en) | 2018-06-13 | 2024-01-16 | Pfizer Inc. | Glp-1 receptor agonists and uses thereof |
| EA202191432A1 (ru) | 2018-11-22 | 2021-10-14 | Цилу Регор Терапьютикс Инк. | Агонисты glp-1r и их применения |
| WO2020151707A1 (zh) * | 2019-01-22 | 2020-07-30 | 江苏恒瑞医药股份有限公司 | 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用 |
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| WO2021219019A1 (en) * | 2020-04-29 | 2021-11-04 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| JP2023538408A (ja) | 2020-08-21 | 2023-09-07 | ターンズ・ファーマシューティカルズ・インコーポレイテッド | Ｇｌｐ－１ｒ作動薬としての化合物 |
| JP7812052B2 (ja) | 2020-09-01 | 2026-02-09 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 縮合イミダゾール誘導体、その調製方法及びその医薬的応用 |
| JP2023546055A (ja) | 2020-10-13 | 2023-11-01 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| WO2022078380A1 (en) | 2020-10-13 | 2022-04-21 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| US20220348564A1 (en) | 2021-03-24 | 2022-11-03 | Eccogene (Shanghai) Co., Ltd. | Phenyl-[1,3]dioxolo[4,5-c]pyridinyl-phenyl-, phenyl-[1,3]dioxolo[4,5-c]pyridinyl-heteroaryl-, or phenyl-(1,3)dioxo[4,5-c]pyridinyl-piperidinyl-methyl-oxetanylmethyl-1h-benzo[d]imidazole-carboxylic acid derivatives and methods of using same |
| CN117177970A (zh) * | 2021-04-30 | 2023-12-05 | 上海翰森生物医药科技有限公司 | 多环类衍生物调节剂、其制备方法和应用 |
| US20240360109A1 (en) | 2021-08-04 | 2024-10-31 | Shanghai Hansoh Biomedical Co., Ltd. | Cycloalkene derivative regulator, preparation method therefor, and application thereof |
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2021
- 2021-09-01 JP JP2023512797A patent/JP7812052B2/ja active Active
- 2021-09-01 EP EP21837580.6A patent/EP4209490B1/en active Active
- 2021-09-01 CN CN202510138614.4A patent/CN119930603A/zh active Pending
- 2021-09-01 DK DK21837580.6T patent/DK4209490T3/da active
- 2021-09-01 CN CN202180050847.9A patent/CN115884969B/zh active Active
- 2021-09-01 EP EP26153808.6A patent/EP4706757A3/en active Pending
- 2021-09-01 WO PCT/CN2021/115915 patent/WO2022007979A1/zh not_active Ceased
- 2021-09-01 CN CN202510138725.5A patent/CN119954797A/zh active Pending
- 2021-09-01 KR KR1020237009937A patent/KR20230058660A/ko active Pending
- 2021-09-01 TW TW110132457A patent/TW202220985A/zh unknown
- 2021-09-01 PL PL21837580.6T patent/PL4209490T3/pl unknown
- 2021-09-01 AU AU2021306414A patent/AU2021306414B2/en active Active
- 2021-09-01 US US18/043,508 patent/US12227499B2/en active Active
- 2021-09-01 ES ES21837580T patent/ES3066183T3/es active Active
- 2021-09-01 FI FIEP21837580.6T patent/FI4209490T3/fi active
- 2021-09-01 MX MX2023001980A patent/MX2023001980A/es unknown
- 2021-09-01 CN CN202510139459.8A patent/CN119930604A/zh active Pending
- 2021-09-01 CA CA3188891A patent/CA3188891A1/en active Pending
- 2021-09-01 PT PT218375806T patent/PT4209490T/pt unknown
- 2021-09-01 CN CN202510139492.0A patent/CN119930605A/zh active Pending
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2024
- 2024-03-21 US US18/612,631 patent/US12473279B2/en active Active
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2025
- 2025-01-07 US US19/012,024 patent/US20250282773A1/en active Pending
- 2025-03-26 US US19/091,638 patent/US12459937B2/en active Active
- 2025-12-24 JP JP2025280769A patent/JP2026053592A/ja active Pending