JP2023538408A5 - - Google Patents

Info

Publication number
JP2023538408A5
JP2023538408A5 JP2023512462A JP2023512462A JP2023538408A5 JP 2023538408 A5 JP2023538408 A5 JP 2023538408A5 JP 2023512462 A JP2023512462 A JP 2023512462A JP 2023512462 A JP2023512462 A JP 2023512462A JP 2023538408 A5 JP2023538408 A5 JP 2023538408A5
Authority
JP
Japan
Prior art keywords
optionally substituted
halo
pharmaceutically acceptable
alkyl
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2023512462A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023538408A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/047015 external-priority patent/WO2022040600A1/en
Publication of JP2023538408A publication Critical patent/JP2023538408A/ja
Publication of JP2023538408A5 publication Critical patent/JP2023538408A5/ja
Ceased legal-status Critical Current

Links

JP2023512462A 2020-08-21 2021-08-20 Glp-1r作動薬としての化合物 Ceased JP2023538408A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063068870P 2020-08-21 2020-08-21
US63/068,870 2020-08-21
PCT/US2021/047015 WO2022040600A1 (en) 2020-08-21 2021-08-20 Compounds as glp-1r agonists

Publications (2)

Publication Number Publication Date
JP2023538408A JP2023538408A (ja) 2023-09-07
JP2023538408A5 true JP2023538408A5 (enExample) 2024-08-26

Family

ID=80350630

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023512462A Ceased JP2023538408A (ja) 2020-08-21 2021-08-20 Glp-1r作動薬としての化合物

Country Status (15)

Country Link
US (2) US20230322744A1 (enExample)
EP (1) EP4199919A4 (enExample)
JP (1) JP2023538408A (enExample)
KR (1) KR20230074486A (enExample)
CN (1) CN116507326A (enExample)
AU (1) AU2021327397A1 (enExample)
BR (1) BR112023003168A2 (enExample)
CA (1) CA3192601A1 (enExample)
CL (2) CL2023000516A1 (enExample)
CO (1) CO2023003322A2 (enExample)
IL (1) IL300795A (enExample)
MX (1) MX2023002108A (enExample)
PE (1) PE20231206A1 (enExample)
TW (1) TWI905252B (enExample)
WO (1) WO2022040600A1 (enExample)

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WO2021219019A1 (en) 2020-04-29 2021-11-04 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
CN117645601A (zh) * 2020-06-10 2024-03-05 重庆康丁医药技术有限公司 一种具有心血管益处的glp-1小分子
PE20231181A1 (es) 2020-08-06 2023-08-11 Gasherbrum Bio Inc Agonistas del glp-1 heterociclicos
JP2023538949A (ja) 2020-08-28 2023-09-12 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環glp-1アゴニスト
JP7812052B2 (ja) 2020-09-01 2026-02-09 江蘇恒瑞医薬股▲ふん▼有限公司 縮合イミダゾール誘導体、その調製方法及びその医薬的応用
EP4247804A1 (en) 2020-11-20 2023-09-27 Gilead Sciences, Inc. Polyheterocyclic glp-1 r modulating compounds
US20240252492A1 (en) * 2021-01-28 2024-08-01 Carmot Therapeutics ,Inc. Gpcr receptor agonists, pharmaceutical compositions comprising the same, and methods for their use
WO2022184849A1 (en) * 2021-03-04 2022-09-09 Les Laboratoires Servier Glp-1r agonists, uses and pharmaceutical compositions thereof
US12180197B2 (en) 2021-03-11 2024-12-31 Gilead Sciences, Inc. GLP-1R modulating compounds
EP4304711A1 (en) 2021-03-11 2024-01-17 Gilead Sciences, Inc. Glp-1r modulating compounds
CN116940561B (zh) * 2021-03-22 2026-08-11 杭州中美华东制药有限公司 噻吩类glp-1受体激动剂及其用途
EP4317145A4 (en) * 2021-03-24 2025-03-12 Shionogi & Co., Ltd Pharmaceutical composition containing glp-1 receptor agonist having fused ring
US20220348564A1 (en) * 2021-03-24 2022-11-03 Eccogene (Shanghai) Co., Ltd. Phenyl-[1,3]dioxolo[4,5-c]pyridinyl-phenyl-, phenyl-[1,3]dioxolo[4,5-c]pyridinyl-heteroaryl-, or phenyl-(1,3)dioxo[4,5-c]pyridinyl-piperidinyl-methyl-oxetanylmethyl-1h-benzo[d]imidazole-carboxylic acid derivatives and methods of using same
LT4271672T (lt) 2021-04-21 2026-03-10 Gilead Sciences, Inc. Karboksibenzimidazolo junginiai, moduliuojantys glp-1r
TWI843104B (zh) 2021-05-20 2024-05-21 美商美國禮來大藥廠 類升糖素肽1受體促效劑
US20240360109A1 (en) * 2021-08-04 2024-10-31 Shanghai Hansoh Biomedical Co., Ltd. Cycloalkene derivative regulator, preparation method therefor, and application thereof
KR20240056719A (ko) 2021-09-08 2024-04-30 시오노기 앤드 컴파니, 리미티드 항비만 작용이 관여하는 질환의 예방 및 치료용 의약
SI4408840T1 (sl) 2021-09-27 2025-12-31 Terns Pharmaceuticals, Inc. Benzimidazolne karboksilne kisline kot agonisti GLP-1R
US20250236627A1 (en) 2021-10-05 2025-07-24 Astrazeneca Ab Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators
WO2023057427A1 (en) 2021-10-05 2023-04-13 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes as glp-1 receptor modulators
WO2023057429A1 (en) 2021-10-05 2023-04-13 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators
US12024507B2 (en) 2021-10-25 2024-07-02 Terns Pharmaceuticals, Inc. Compounds as GLP-1R agonists
US20250066338A1 (en) 2021-12-16 2025-02-27 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
US20250042882A1 (en) 2021-12-16 2025-02-06 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
AU2023224854A1 (en) * 2022-02-23 2024-10-03 Terns Pharmaceuticals, Inc. Compounds as glp-1r agonists
CA3246495A1 (en) * 2022-03-25 2023-09-28 Ildong Pharmaceutical Co., Ltd. NEW GLP-1 RECEPTOR AGONIST COMPOUND SALT, ITS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION INCLUDING IT
CN116574092B (zh) * 2022-05-20 2024-08-20 成都地奥九泓制药厂 苯并咪唑或氮杂苯并咪唑类化合物、其制备方法及其应用
CN120289449A (zh) * 2022-07-18 2025-07-11 厦门市博瑞来医药科技有限公司 一种合成非甾体类fxr调节剂的化合物
CN119907794A (zh) 2022-09-22 2025-04-29 盐野义制药株式会社 具有glp-1受体激动剂作用的稠环化合物
US20260098031A1 (en) * 2022-09-22 2026-04-09 Shionogi & Co., Ltd. Monocyclic compound having glp-1 receptor agonist activity
CN116102543B (zh) * 2022-10-21 2025-07-22 江南大学 一种glp-1r激动剂、合成方法及其用途
WO2024102625A1 (en) 2022-11-11 2024-05-16 Eli Lilly And Company Glucagon-like peptide 1 receptor agonists
CR20250178A (es) 2022-11-16 2025-06-06 Lilly Co Eli Agonistas del receptor del péptido-1 similar al glucagón
KR20250139383A (ko) * 2023-02-02 2025-09-23 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 시클로알켄계 화합물의 염, 결정형 및 이의 제조 방법과 응용
PE20252787A1 (es) 2023-04-07 2025-12-22 Terns Pharmaceuticals Inc Combinacion que comprende un agonista de thr-beta y un agonista de glp-1r para su uso en el tratamiento de un trastorno hepatico o una enfermedad cardiometabolica
WO2024212742A1 (zh) * 2023-04-10 2024-10-17 上海研健新药研发有限公司 一种glp-1r激动剂,其制备方法和应用
EP4777197A2 (en) 2023-09-14 2026-07-22 Ascletis Pharma (China) Co., Limited Glp-1r agonist and therapeutic method thereof
EP4780818A1 (en) * 2023-09-21 2026-07-29 Yunovia Co., Ltd. Method for preparing substituted fused imidazole derivative
WO2025109387A1 (en) 2023-11-24 2025-05-30 Ascletis Pharma (China) Co., Limited Glp-1r agonist and therapeutic method thereof
TW202600132A (zh) 2024-03-08 2026-01-01 美商安尼波那生物公司 用於治療肥胖症及提高減重之方法
WO2026092580A1 (en) 2024-10-30 2026-05-07 Ascletis Pharma (China) Co., Limited Glp-1r\gipr\gcgr modulator in combination with thr-beta modulator for treatment of metabolic diseases
WO2026092581A1 (en) 2024-10-30 2026-05-07 Ascletis Pharma (China) Co., Limited Thyroid hormone receptor beta modulator alone or in combination with a modulator of glp-1r, gipr or gcgr, for use in the treatment of obesity or overweight or for treating alopecia areata
WO2026092583A1 (en) 2024-10-30 2026-05-07 Ascletis Pharma (China) Co., Limited Thr-beta modulators, alone or in combination with glp-1r\gipr\gcgr modulators for the treatment of metabolic diseases and alopecia areata diseases
WO2026151251A1 (ko) * 2025-01-10 2026-07-16 유노비아 주식회사 Glp-1r 작용제를 포함하는 대사성 질환 예방 또는 치료용 조성물

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Publication number Priority date Publication date Assignee Title
WO2018109607A1 (en) * 2016-12-16 2018-06-21 Pfizer Inc. Glp-1 receptor agonists and uses thereof
FI3806855T3 (fi) * 2018-06-15 2023-05-04 Pfizer Glp-1 -reseptorin agonisteja ja niiden käyttöjä
JP7161605B2 (ja) * 2018-08-31 2022-10-26 ファイザー・インク Nash/nafldおよび関連疾患の治療のための組合せ
EA202191432A1 (ru) * 2018-11-22 2021-10-14 Цилу Регор Терапьютикс Инк. Агонисты glp-1r и их применения
ES3029360T3 (en) * 2019-11-15 2025-06-24 Ildong Pharmaceutical Co Ltd Glp-1 receptor agonist and use thereof
CA3217720A1 (en) * 2021-05-03 2022-11-10 Xiaohui Du Benzimidazoyl glp-1 receptor agonists, pharmaceutical compositions comprising the same, and methods for their use
US20240382471A1 (en) * 2021-07-21 2024-11-21 Hepagene Therapeutics (HK) Limited Glucagon-like peptide-1 receptor modulators and uses thereof

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