JP2023538393A5 - - Google Patents

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Publication number
JP2023538393A5
JP2023538393A5 JP2023512226A JP2023512226A JP2023538393A5 JP 2023538393 A5 JP2023538393 A5 JP 2023538393A5 JP 2023512226 A JP2023512226 A JP 2023512226A JP 2023512226 A JP2023512226 A JP 2023512226A JP 2023538393 A5 JP2023538393 A5 JP 2023538393A5
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JP
Japan
Prior art keywords
phenyl
methylsulfonyl
pyridine
imidazo
methyl
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JP2023512226A
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English (en)
Japanese (ja)
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JP7813775B2 (ja
JP2023538393A (ja
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Priority claimed from PCT/US2021/046420 external-priority patent/WO2022040259A1/en
Publication of JP2023538393A publication Critical patent/JP2023538393A/ja
Publication of JP2023538393A5 publication Critical patent/JP2023538393A5/ja
Application granted granted Critical
Publication of JP7813775B2 publication Critical patent/JP7813775B2/ja
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JP2023512226A 2020-08-19 2021-08-18 線維症の処置のためのtlr9の阻害剤としてのイミダゾ[1,2-a]ピリジンおよび[1,2,4]トリアゾロ[1,5-a]ピリジン誘導体 Active JP7813775B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063067452P 2020-08-19 2020-08-19
US63/067,452 2020-08-19
PCT/US2021/046420 WO2022040259A1 (en) 2020-08-19 2021-08-18 Imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine derivatives as tlr9 inhibitors for the treatment of fibrosis

Publications (3)

Publication Number Publication Date
JP2023538393A JP2023538393A (ja) 2023-09-07
JP2023538393A5 true JP2023538393A5 (cg-RX-API-DMAC10.html) 2024-08-26
JP7813775B2 JP7813775B2 (ja) 2026-02-13

Family

ID=77693624

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023512226A Active JP7813775B2 (ja) 2020-08-19 2021-08-18 線維症の処置のためのtlr9の阻害剤としてのイミダゾ[1,2-a]ピリジンおよび[1,2,4]トリアゾロ[1,5-a]ピリジン誘導体

Country Status (14)

Country Link
US (1) US12486267B2 (cg-RX-API-DMAC10.html)
EP (1) EP4200297B1 (cg-RX-API-DMAC10.html)
JP (1) JP7813775B2 (cg-RX-API-DMAC10.html)
KR (1) KR20230053644A (cg-RX-API-DMAC10.html)
CN (1) CN116096717B (cg-RX-API-DMAC10.html)
AR (1) AR123281A1 (cg-RX-API-DMAC10.html)
AU (1) AU2021328575A1 (cg-RX-API-DMAC10.html)
BR (1) BR112023002737A2 (cg-RX-API-DMAC10.html)
CA (1) CA3190065A1 (cg-RX-API-DMAC10.html)
ES (1) ES3071068T3 (cg-RX-API-DMAC10.html)
IL (1) IL300727A (cg-RX-API-DMAC10.html)
MX (1) MX2023001885A (cg-RX-API-DMAC10.html)
TW (1) TW202227432A (cg-RX-API-DMAC10.html)
WO (1) WO2022040259A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11807622B2 (en) 2019-01-30 2023-11-07 Insilico Medicine Ip Limited TLR 9 inhibitors
KR20240148413A (ko) * 2022-02-18 2024-10-11 브리스톨-마이어스 스큅 컴퍼니 Tlr9의 억제제로서 유용한 치환된 비시클릭 헤테로아릴 화합물
CN120230100B (zh) * 2025-05-30 2025-09-05 中国药科大学 一种咪唑并[1,2-a]吡嗪或咪唑并[1,2-a]吡啶类化合物及其医药用途

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060235037A1 (en) 2005-04-15 2006-10-19 Purandare Ashok V Heterocyclic inhibitors of protein arginine methyl transferases
GB0602178D0 (en) 2006-02-03 2006-03-15 Merck Sharp & Dohme Therapeutic treatment
JP2009532501A (ja) 2006-04-04 2009-09-10 ミリアド ジェネティクス, インコーポレイテッド 疾患および障害のための化合物
AU2007272009A1 (en) 2006-07-12 2008-01-17 Syngenta Limited Triazolopyridine derivatives as herbicides
EP2205085A1 (en) 2007-09-25 2010-07-14 Merck Sharp & Dohme Corp. 2-aryl or heteroaryl indole derivatives
EP2340243B1 (en) 2008-10-17 2014-10-08 Boehringer Ingelheim International GmbH Heteroaryl substituted indole compounds useful as mmp-13 inhibitors
BR112012006630A2 (pt) 2009-09-24 2016-05-03 Hoffmann La Roche derivados em indol como moduladores dos canais de cálcio ativados para liberação de cálcio (crac)
TWI617559B (zh) 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 2-芳基咪唑并[1,2-b]嗒.2-苯基咪唑并[1,2-a]吡啶,和2-苯基咪唑并[1,2-a]吡衍生物
EP2757883B1 (en) 2011-09-22 2021-01-13 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
US20130158049A1 (en) 2011-12-20 2013-06-20 Hoffmann-La Roche Inc. 7-azaindole inhibitors of crac
US20130158066A1 (en) 2011-12-20 2013-06-20 Hoffmann-La Roche Inc. 4-azaindole inhibitors of crac
WO2013156431A1 (en) 2012-04-17 2013-10-24 Syngenta Participations Ag Pesticidally active pyridyl- and pyrimidyl- substituted thiazole and thiadiazole derivatives
WO2013191113A1 (ja) 2012-06-18 2013-12-27 住友化学株式会社 縮合複素環化合物
US9643967B2 (en) 2013-12-13 2017-05-09 Takeda Pharmaceutical Company Limited Pyrrolo[3,2-c]pyridine derivatives as TLR inhibitors
EP3194394B1 (en) * 2014-09-16 2019-01-09 Syngenta Participations AG Pesticidally active tetracyclic derivatives with sulphur containing substituents
CA2999852A1 (en) 2015-09-29 2017-04-06 Oncotherapy Science, Inc. Bicyclic compound and use thereof for inhibiting suv39h2
US10071079B2 (en) 2016-06-29 2018-09-11 Bristol-Myers Squibb Company [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
CN109715617B (zh) 2016-07-30 2022-04-19 百时美施贵宝公司 作为tlr7、tlr8或tlr9抑制剂的二甲氧基苯基取代的吲哚化合物
ES2902504T3 (es) 2016-09-09 2022-03-28 Bristol Myers Squibb Co Compuestos de indol sustituidos con piridilo
US11370794B2 (en) * 2016-11-11 2022-06-28 Dynavax Technologies Corporation Toll-like receptor antagonist compounds and methods of use
WO2018165112A1 (en) 2017-03-09 2018-09-13 Oncotherapy Science, Inc. Bicyclic compound and use thereof for inhibiting histone methyltransferase
EP3661926B1 (en) 2017-08-04 2022-02-23 Bristol-Myers Squibb Company Substituted indole compounds useful as inhibitors of tlr7/8/9
CN110997670B (zh) 2017-08-04 2022-11-01 百时美施贵宝公司 [1,2,4]三唑并[4,3-a]吡啶基取代的吲哚化合物
CN111448190B (zh) 2017-11-14 2023-09-26 百时美施贵宝公司 取代的吲哚化合物
US12030878B2 (en) 2017-12-15 2024-07-09 Bristol-Myers Squibb Company Substituted indole ether compounds
MX2020006168A (es) 2017-12-18 2020-08-13 Bristol Myers Squibb Co Compuestos de 4-azaindol.
EP3728253B1 (en) 2017-12-19 2024-03-27 Bristol-Myers Squibb Company 6-azaindole compounds
EA202091474A1 (ru) 2017-12-19 2020-11-18 Бристол-Маерс Сквибб Компани Замещенные индольные соединения, применимые в качестве ингибиторов tlr
WO2019126081A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Amide substituted indole compounds useful as tlr inhibitors
KR102730859B1 (ko) 2017-12-20 2024-11-15 브리스톨-마이어스 스큅 컴퍼니 아릴 및 헤테로아릴 치환된 인돌 화합물
JP7287967B2 (ja) 2017-12-20 2023-06-06 ブリストル-マイヤーズ スクイブ カンパニー Tlr阻害剤として有効なアミノインドール化合物
EA202091530A1 (ru) 2017-12-20 2020-09-14 Бристол-Маерс Сквибб Компани Диазаиндольные соединения
EP4089096A4 (en) 2020-01-09 2024-01-03 Sumitomo Chemical Company, Limited HETEROCYCLIC COMPOUND AND MEANS THEREOF FOR CONTROLLING HARMFUL ARTHROPODS

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