JP2023538129A5 - - Google Patents
Info
- Publication number
- JP2023538129A5 JP2023538129A5 JP2023512697A JP2023512697A JP2023538129A5 JP 2023538129 A5 JP2023538129 A5 JP 2023538129A5 JP 2023512697 A JP2023512697 A JP 2023512697A JP 2023512697 A JP2023512697 A JP 2023512697A JP 2023538129 A5 JP2023538129 A5 JP 2023538129A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid selected
- aav capsid
- seq
- furthermore
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063068614P | 2020-08-21 | 2020-08-21 | |
| US63/068,614 | 2020-08-21 | ||
| PCT/US2021/046904 WO2022040527A2 (en) | 2020-08-21 | 2021-08-20 | Adeno-associated virus compositions having preferred expression levels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023538129A JP2023538129A (ja) | 2023-09-06 |
| JP2023538129A5 true JP2023538129A5 (https=) | 2024-08-28 |
Family
ID=80323313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023512697A Pending JP2023538129A (ja) | 2020-08-21 | 2021-08-20 | 好ましい発現レベルを有するアデノ随伴ウイルス組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230303630A1 (https=) |
| EP (1) | EP4199972A4 (https=) |
| JP (1) | JP2023538129A (https=) |
| CN (1) | CN117321213A (https=) |
| AU (1) | AU2021329527A1 (https=) |
| CA (1) | CA3192600A1 (https=) |
| WO (1) | WO2022040527A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113166208B (zh) | 2018-10-02 | 2024-11-22 | 沃雅戈治疗公司 | 重新定向aav衣壳的嗜性 |
| TWI900553B (zh) | 2020-05-13 | 2025-10-11 | 美商航海家醫療公司 | Aav蛋白殼之趨性重定向 |
| JP2024513949A (ja) * | 2021-04-13 | 2024-03-27 | カプシダ， インコーポレイテッド | 脳内発現レベルが高いａａｖ組成物 |
| KR20240095539A (ko) | 2021-10-08 | 2024-06-25 | 디노 테라퓨틱스, 인코포레이티드 | 캡시드 변이체 및 이의 사용 방법 |
| EP4426716A1 (en) | 2021-11-02 | 2024-09-11 | Voyager Therapeutics, Inc. | Aav capsid variants and uses thereof |
| CA3254573A1 (en) * | 2022-03-24 | 2023-09-28 | Capsida, Inc. | SELECTED VAA COMPOSITIONS WITH A PREFERRED BRAIN ENRICHEMENT |
| CN114774373B (zh) * | 2022-04-27 | 2024-07-05 | 北京市农林科学院 | 信鸽新城疫病毒基因工程改造弱毒株及其制备方法和应用 |
| EP4269426A1 (en) * | 2022-04-29 | 2023-11-01 | Ospedale San Raffaele S.r.l. | Gene therapy |
| EP4519284A2 (en) * | 2022-05-06 | 2025-03-12 | Capsida, Inc. | Adeno-associated virus compositions having increased brain enrichment |
| CA3256915A1 (en) * | 2022-05-17 | 2023-11-23 | Capsida, Inc. | SELECTED ADENE-ASSOCIATED VIRUS COMPOSITIONS HAVING PREFERRED LEVELS OF CEREBRAL, SPINAL CORD AND/OR CARDIAC EXPRESSION |
| US20250346637A1 (en) * | 2022-06-16 | 2025-11-13 | Capsida, Inc. | Adeno-associated virus compositions having increased brain enrichment and decreased liver enrichment |
| WO2024086747A1 (en) | 2022-10-19 | 2024-04-25 | Affinia Therapeutics Inc. | Recombinant aavs with improved tropism and specificity |
| EP4605538A2 (en) * | 2022-10-19 | 2025-08-27 | Capsida Biotherapeutics, Inc. | Adeno-associated virus compositions having preferredbrain enrichment and low liver enrichment |
| WO2024191778A1 (en) | 2023-03-10 | 2024-09-19 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| WO2024199270A1 (zh) * | 2023-03-27 | 2024-10-03 | 浙江大学 | 氨基酸序列的生成与筛选方法及其系统 |
| KR20260045798A (ko) * | 2023-06-30 | 2026-04-03 | 캡시다 바이오테라퓨틱스, 인크. | 증가된 뇌 풍부화를 갖는 아데노-연관 바이러스 조성물 |
| AU2024332181A1 (en) | 2023-08-31 | 2026-02-12 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| TW202545971A (zh) | 2024-02-08 | 2025-12-01 | 美商戴諾治療公司 | 殼體多肽及其使用方法 |
| WO2025213066A1 (en) * | 2024-04-05 | 2025-10-09 | Capsida Biotherapeutics, Inc. | Adeno-associated virus compositions for treating parkinson's disease (pd) |
| WO2025231383A1 (en) * | 2024-05-03 | 2025-11-06 | Capsida Biotherapeutics, Inc. | Compositions and methods of delivering a therapeutic across the blood-brain barrier via the pl16 receptor |
| WO2026064442A2 (en) | 2024-09-18 | 2026-03-26 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6710036B2 (en) * | 1997-07-25 | 2004-03-23 | Avigen, Inc. | Induction of immune response to antigens expressed by recombinant adeno-associated virus |
| CN105755044A (zh) * | 2011-04-22 | 2016-07-13 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体及其使用方法 |
| DE102014207498A1 (de) * | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| KR102423442B1 (ko) * | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| AU2017302013B2 (en) * | 2016-07-29 | 2022-05-26 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| WO2020014471A1 (en) * | 2018-07-11 | 2020-01-16 | The Brigham And Women's Hospital, Inc. | Methods and compositions for delivery of agents across the blood-brain barrier |
| WO2020028751A2 (en) * | 2018-08-03 | 2020-02-06 | Voyager Therapeutics, Inc. | Aav variants with enhanced tropism |
| CN113966399A (zh) * | 2018-09-26 | 2022-01-21 | 加州理工学院 | 用于靶向基因疗法的腺相关病毒组合物 |
| EP3856762A1 (en) * | 2018-09-28 | 2021-08-04 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| CN113166208B (zh) * | 2018-10-02 | 2024-11-22 | 沃雅戈治疗公司 | 重新定向aav衣壳的嗜性 |
-
2021
- 2021-08-20 AU AU2021329527A patent/AU2021329527A1/en active Pending
- 2021-08-20 CN CN202180071840.5A patent/CN117321213A/zh active Pending
- 2021-08-20 CA CA3192600A patent/CA3192600A1/en active Pending
- 2021-08-20 WO PCT/US2021/046904 patent/WO2022040527A2/en not_active Ceased
- 2021-08-20 JP JP2023512697A patent/JP2023538129A/ja active Pending
- 2021-08-20 EP EP21859200.4A patent/EP4199972A4/en active Pending
- 2021-08-20 US US18/022,056 patent/US20230303630A1/en active Pending
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