JP2023536068A - クレノラニブの結晶形態およびそれを用いる方法 - Google Patents

クレノラニブの結晶形態およびそれを用いる方法 Download PDF

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Publication number
JP2023536068A
JP2023536068A JP2023503219A JP2023503219A JP2023536068A JP 2023536068 A JP2023536068 A JP 2023536068A JP 2023503219 A JP2023503219 A JP 2023503219A JP 2023503219 A JP2023503219 A JP 2023503219A JP 2023536068 A JP2023536068 A JP 2023536068A
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Prior art keywords
crystalline form
cancer
peaks
powder
diffraction pattern
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JP2023503219A
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Japanese (ja)
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JP2023536068A5 (https=
Inventor
ジャイン，ビナイ
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Arog Pharmaceuticals LLC
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Arog Pharmaceuticals LLC
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Priority claimed from PCT/US2021/033618 external-priority patent/WO2022019998A1/en
Publication of JP2023536068A publication Critical patent/JP2023536068A/ja
Publication of JP2023536068A5 publication Critical patent/JP2023536068A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2023503219A 2020-07-20 2021-05-21 クレノラニブの結晶形態およびそれを用いる方法 Pending JP2023536068A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063053921P 2020-07-20 2020-07-20
US63/053,921 2020-07-20
PCT/US2021/033618 WO2022019998A1 (en) 2020-07-20 2021-05-21 Crystal forms of crenolanib and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2023536068A true JP2023536068A (ja) 2023-08-23
JP2023536068A5 JP2023536068A5 (https=) 2024-01-24

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JP2023503219A Pending JP2023536068A (ja) 2020-07-20 2021-05-21 クレノラニブの結晶形態およびそれを用いる方法

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Country Link
EP (1) EP4181923A4 (https=)
JP (1) JP2023536068A (https=)
CN (1) CN113956245A (https=)
CA (1) CA3186319A1 (https=)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501309A (ja) * 2002-08-28 2006-01-12 ファイザー・プロダクツ・インク 抗増殖剤として有効な新規ベンゾイミダゾール誘導体
JP2007516168A (ja) * 2003-06-24 2007-06-21 ファイザー・プロダクツ・インク １−［２−（ベンゾイミダゾル−１−イル）キノリン−８−イル］−ピペリジン−４−イルアミン誘導体の製造方法
JP2014065696A (ja) * 2012-09-26 2014-04-17 Arog Pharmaceuticals Llc 変異型ｃ−ｋｉｔの阻害方法
JP2014097929A (ja) * 2012-09-21 2014-05-29 Arog Pharmaceuticals Llc 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法
JP2016508148A (ja) * 2013-01-07 2016-03-17 エーアールオージー ファーマスーティカルズ，インクＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 変異ｆｌｔ３増殖性障害の治療剤クレノラニブ（ｃｒｅｎｏｌａｎｉｂ）
JP2019532011A (ja) * 2016-11-02 2019-11-07 アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ
WO2020123991A1 (en) * 2018-12-13 2020-06-18 Arog Pharmaceuticals, Inc. Crenolanib combination therapy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105294719B (zh) * 2015-11-18 2017-12-22 乳源瑶族自治县大众药品贸易有限公司 一种氨基喹唑啉类衍生物的二对甲苯磺酸盐及其晶型

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501309A (ja) * 2002-08-28 2006-01-12 ファイザー・プロダクツ・インク 抗増殖剤として有効な新規ベンゾイミダゾール誘導体
JP2007516168A (ja) * 2003-06-24 2007-06-21 ファイザー・プロダクツ・インク １−［２−（ベンゾイミダゾル−１−イル）キノリン−８−イル］−ピペリジン−４−イルアミン誘導体の製造方法
JP2014097929A (ja) * 2012-09-21 2014-05-29 Arog Pharmaceuticals Llc 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法
JP2014065696A (ja) * 2012-09-26 2014-04-17 Arog Pharmaceuticals Llc 変異型ｃ−ｋｉｔの阻害方法
JP2016508148A (ja) * 2013-01-07 2016-03-17 エーアールオージー ファーマスーティカルズ，インクＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 変異ｆｌｔ３増殖性障害の治療剤クレノラニブ（ｃｒｅｎｏｌａｎｉｂ）
JP2019532011A (ja) * 2016-11-02 2019-11-07 アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ
WO2020123991A1 (en) * 2018-12-13 2020-06-18 Arog Pharmaceuticals, Inc. Crenolanib combination therapy

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
""新医薬品の規格及び試験方法の設定について"", 医薬審発第568号, JPN6010021254, 1 May 2001 (2001-05-01), ISSN: 0005732930 *
BERGE，S. M., ET AL., JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, JPN5004004439, 1977, US, pages 1 - 19, ISSN: 0005732928 *
STEPHEN BYRN ET AL.: ""Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations"", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, JPN5013009960, 1995, pages 945 - 954, ISSN: 0005558335 *
大嶋寛: ""結晶多形・擬多形の析出挙動と制御"", PHARM STAGE, vol. 6, no. 10, JPN6011001457, 15 January 2007 (2007-01-15), pages 48 - 53, ISSN: 0005732931 *
山野光久: "医薬品のプロセス研究における結晶多形現象への取り組み", 有機合成化学協会誌, vol. 65, no. 9, JPN6010003277, 1 September 2007 (2007-09-01), ISSN: 0005732933 *
川口洋子，外２名: ""医薬品と結晶多形"", 生活工学研究, vol. 第４巻第２号, JPN6014015069, 2002, pages 310 - 317, ISSN: 0005732929 *
浅原 照三, 溶剤ハンドブック, JPN6011026738, 1985, pages 47 - 51, ISSN: 0005732935 *
社団法人日本化学会編, 第４版実験化学講座１基本操作Ｉ, vol. 第１８４−１８９頁, JPN7008003682, 5 April 1996 (1996-04-05), ISSN: 0005732936 *
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, vol. 6, no. 10, JPN6009053755, 15 January 2007 (2007-01-15), pages 20 - 25, ISSN: 0005558333 *

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Publication number Publication date
CN113956245A (zh) 2022-01-21
EP4181923A4 (en) 2024-08-07
CA3186319A1 (en) 2022-01-27
EP4181923A1 (en) 2023-05-24

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