JP2023531164A - 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト - Google Patents

先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト Download PDF

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JP2023531164A
JP2023531164A JP2022576006A JP2022576006A JP2023531164A JP 2023531164 A JP2023531164 A JP 2023531164A JP 2022576006 A JP2022576006 A JP 2022576006A JP 2022576006 A JP2022576006 A JP 2022576006A JP 2023531164 A JP2023531164 A JP 2023531164A
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compound
formula
pharmaceutically acceptable
acceptable salt
administration
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JP2023531164A5 (https=
Inventor
ロバート エイチ． ファーバー，
ジーン エル． チャン，
エイリー ロバーツ，
ゴードン ビー． ジュニア カトラー，
アーリーン ナカニシ，
アン シャルリエ，
ゴードン ラファエル ローウェン，
シャオピン ジャン，
ナグディープ ギリ，
スコット スティルン，
ブライアン セイヤーズ，
グレーム テイラー，
クリスティーナ マリー コスタ，
ステイシー パークス，
アンソニー ディー． ヴィッカリー，
クリスティー エム． ダウニング，
キングスリー イヨハ，
アヤンダ ヌグウェニャ－ジョーンズ，
ガービンダー メートン，
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Sanofi SA
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Sanofi SA
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Publication of JP2023531164A publication Critical patent/JP2023531164A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022—Organic macromolecular compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2022576006A 2020-06-10 2021-06-09 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト Pending JP2023531164A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR2006039 2020-06-10
FR2006039 2020-06-10
PCT/US2021/036668 WO2021252669A1 (en) 2020-06-10 2021-06-09 Crf1 receptor antagonist for the treatment of congenital adrenal hyperplasia

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JP2023531164A true JP2023531164A (ja) 2023-07-21
JP2023531164A5 JP2023531164A5 (https=) 2024-06-17

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JP2022576006A Pending JP2023531164A (ja) 2020-06-10 2021-06-09 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト

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US (1) US20230255942A1 (https=)
EP (1) EP4164636A1 (https=)
JP (1) JP2023531164A (https=)
KR (1) KR20230038458A (https=)
CN (1) CN116096373A (https=)
AU (1) AU2021286565A1 (https=)
BR (1) BR112022024875A2 (https=)
CA (1) CA3181084A1 (https=)
CL (1) CL2022003437A1 (https=)
CO (1) CO2022017764A2 (https=)
CR (1) CR20220624A (https=)
DO (1) DOP2022000277A (https=)
EC (1) ECSP22092977A (https=)
IL (1) IL298901A (https=)
JO (1) JOP20220329A1 (https=)
MA (1) MA58993A1 (https=)
MX (1) MX2022015159A (https=)
PE (1) PE20240544A1 (https=)
PH (1) PH12022553389A1 (https=)
TW (1) TWI911229B (https=)
WO (1) WO2021252669A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS65839B1 (sr) 2014-01-21 2024-09-30 Neurocrine Biosciences Inc Crf1 receptor antagonisti za tretman kongenitalne adrenalne hiperplazije
WO2017035409A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
EP3589287B1 (en) 2017-03-01 2022-09-14 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for treatment of medical disorders
US20220023266A1 (en) 2018-12-07 2022-01-27 Neurocrine Biosciences, Inc. Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
WO2020131974A1 (en) 2018-12-17 2020-06-25 Achillion Pharmaceuticals, Inc. Targeted dosing for the treatment of complement mediated disorders
JP7623365B2 (ja) 2019-09-27 2025-01-28 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｃｒｆ受容体アンタゴニストおよび使用方法
CA3201039A1 (en) * 2023-03-13 2025-03-12 Alexion Pharmaceuticals, Inc. Formulations of danicopan and methods of use thereof
WO2024206769A1 (en) * 2023-03-30 2024-10-03 Neurocrine Biosciences, Inc. Dosage regime of crinecerfont for treating congenital adrenal hyperplasia
TW202444356A (zh) * 2023-05-08 2024-11-16 美商紐羅克里生物科學有限公司 Crf拮抗劑之投與方法
WO2025240605A1 (en) 2024-05-15 2025-11-20 Neurocrine Biosciences, Inc. Combination treatment

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2003505380A (ja) * 1999-07-15 2003-02-12 サノフィ−サンテラボ 新規アミノチアゾール誘導体、それらの製造およびそれらを含有する医薬組成物
WO2016065177A1 (en) * 2014-10-22 2016-04-28 The Trustees Of The University Of Pennsylvania Method of treating depression and other stress related disorders
JP2017503030A (ja) * 2014-01-21 2017-01-26 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト

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HUP0900267A2 (en) 2009-04-30 2011-03-28 Sanofi Aventis Process for preparing of thiazole amines and intermediates thereof
US20220023266A1 (en) * 2018-12-07 2022-01-27 Neurocrine Biosciences, Inc. Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003505380A (ja) * 1999-07-15 2003-02-12 サノフィ−サンテラボ 新規アミノチアゾール誘導体、それらの製造およびそれらを含有する医薬組成物
JP2017503030A (ja) * 2014-01-21 2017-01-26 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト
WO2016065177A1 (en) * 2014-10-22 2016-04-28 The Trustees Of The University Of Pennsylvania Method of treating depression and other stress related disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Neurocrine Biosciences Reports Positive Phase II Data for Crinecerfont in Adults with Congenital Adr", PRNEWSWIRE, JPN6025027512, 8 June 2020 (2020-06-08), pages 1 - 3, ISSN: 0005836355 *

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CO2022017764A2 (es) 2023-04-27
MA58993A1 (fr) 2023-09-27
DOP2022000277A (es) 2023-04-16
JOP20220329A1 (ar) 2022-12-04
CA3181084A1 (en) 2021-12-16
PH12022553389A1 (en) 2024-03-25
BR112022024875A2 (pt) 2022-12-27
EP4164636A1 (en) 2023-04-19
CN116096373A (zh) 2023-05-09
TWI911229B (zh) 2026-01-11
ECSP22092977A (es) 2023-03-31
MX2022015159A (es) 2023-03-01
PE20240544A1 (es) 2024-03-19
KR20230038458A (ko) 2023-03-20
CR20220624A (es) 2023-07-06
US20230255942A1 (en) 2023-08-17
TW202214235A (zh) 2022-04-16
IL298901A (en) 2023-02-01
WO2021252669A1 (en) 2021-12-16
AU2021286565A1 (en) 2023-02-02
CL2022003437A1 (es) 2023-05-26

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