CN116096373A - 用于治疗先天性肾上腺增生症的crf1受体拮抗剂 - Google Patents

用于治疗先天性肾上腺增生症的crf1受体拮抗剂 Download PDF

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Publication number
CN116096373A
CN116096373A CN202180055808.8A CN202180055808A CN116096373A CN 116096373 A CN116096373 A CN 116096373A CN 202180055808 A CN202180055808 A CN 202180055808A CN 116096373 A CN116096373 A CN 116096373A
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China
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compound
formula
pharmaceutically acceptable
acceptable salt
administration
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Pending
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CN202180055808.8A
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English (en)
Chinese (zh)
Inventor
罗伯特·H·法博
瑾秀·林·陈
艾里·罗伯茨
小戈登·B·卡特勒
阿琳·纳卡尼希
安妮·查理尔
戈登·拉斐尔·洛文
张晓平
纳吉普·吉里
斯科特·斯蒂恩
布莱恩·萨耶斯
格雷姆·泰勒
克里斯蒂娜·玛丽·科斯塔
斯泰西·帕克斯
安东尼·D·维克里
克里斯蒂·M·唐宁
金斯利·伊约哈
阿扬达·恩格尼娅·琼斯
古尔弗德·梅顿
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Sanofi Aventis France
Neurocrine Biosciences Inc
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Sanofi Aventis France
Neurocrine Biosciences Inc
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Publication of CN116096373A publication Critical patent/CN116096373A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN202180055808.8A 2020-06-10 2021-06-09 用于治疗先天性肾上腺增生症的crf1受体拮抗剂 Pending CN116096373A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FRFR2006039 2020-06-10
FR2006039 2020-06-10
PCT/US2021/036668 WO2021252669A1 (en) 2020-06-10 2021-06-09 Crf1 receptor antagonist for the treatment of congenital adrenal hyperplasia

Publications (1)

Publication Number Publication Date
CN116096373A true CN116096373A (zh) 2023-05-09

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CN202180055808.8A Pending CN116096373A (zh) 2020-06-10 2021-06-09 用于治疗先天性肾上腺增生症的crf1受体拮抗剂

Country Status (21)

Country Link
US (1) US20230255942A1 (https=)
EP (1) EP4164636A1 (https=)
JP (1) JP2023531164A (https=)
KR (1) KR20230038458A (https=)
CN (1) CN116096373A (https=)
AU (1) AU2021286565A1 (https=)
BR (1) BR112022024875A2 (https=)
CA (1) CA3181084A1 (https=)
CL (1) CL2022003437A1 (https=)
CO (1) CO2022017764A2 (https=)
CR (1) CR20220624A (https=)
DO (1) DOP2022000277A (https=)
EC (1) ECSP22092977A (https=)
IL (1) IL298901A (https=)
JO (1) JOP20220329A1 (https=)
MA (1) MA58993A1 (https=)
MX (1) MX2022015159A (https=)
PE (1) PE20240544A1 (https=)
PH (1) PH12022553389A1 (https=)
TW (1) TWI911229B (https=)
WO (1) WO2021252669A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS65839B1 (sr) 2014-01-21 2024-09-30 Neurocrine Biosciences Inc Crf1 receptor antagonisti za tretman kongenitalne adrenalne hiperplazije
WO2017035409A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
EP3589287B1 (en) 2017-03-01 2022-09-14 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for treatment of medical disorders
US20220023266A1 (en) 2018-12-07 2022-01-27 Neurocrine Biosciences, Inc. Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
WO2020131974A1 (en) 2018-12-17 2020-06-25 Achillion Pharmaceuticals, Inc. Targeted dosing for the treatment of complement mediated disorders
JP7623365B2 (ja) 2019-09-27 2025-01-28 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｃｒｆ受容体アンタゴニストおよび使用方法
CA3201039A1 (en) * 2023-03-13 2025-03-12 Alexion Pharmaceuticals, Inc. Formulations of danicopan and methods of use thereof
WO2024206769A1 (en) * 2023-03-30 2024-10-03 Neurocrine Biosciences, Inc. Dosage regime of crinecerfont for treating congenital adrenal hyperplasia
TW202444356A (zh) * 2023-05-08 2024-11-16 美商紐羅克里生物科學有限公司 Crf拮抗劑之投與方法
WO2025240605A1 (en) 2024-05-15 2025-11-20 Neurocrine Biosciences, Inc. Combination treatment

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN113518616A (zh) * 2018-12-07 2021-10-19 纽罗克里生物科学有限公司 用于治疗先天性肾上腺皮质增生症的crf1受体拮抗剂、其药物制剂和固体形式

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Publication number Priority date Publication date Assignee Title
FR2796380B3 (fr) * 1999-07-15 2001-08-17 Sanofi Synthelabo Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
HUP0900267A2 (en) 2009-04-30 2011-03-28 Sanofi Aventis Process for preparing of thiazole amines and intermediates thereof
RS65839B1 (sr) * 2014-01-21 2024-09-30 Neurocrine Biosciences Inc Crf1 receptor antagonisti za tretman kongenitalne adrenalne hiperplazije
WO2016065177A1 (en) * 2014-10-22 2016-04-28 The Trustees Of The University Of Pennsylvania Method of treating depression and other stress related disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113518616A (zh) * 2018-12-07 2021-10-19 纽罗克里生物科学有限公司 用于治疗先天性肾上腺皮质增生症的crf1受体拮抗剂、其药物制剂和固体形式

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEUROCRINE BIOSCIENCES: "Neurocrine Biosciences Reports Positive Phase II Data for Crinecerfont in Adults with Congenital Adrenal Hyperplasia at ENDO Online 2020", pages 1 - 5, Retrieved from the Internet <URL:https://www.prnewswire.com/news-releases/neurocrine-biosciences-reports-positive-phase-ii-data-for crinecerfont -in-adults-with- congenital - adrenal - hyperplasia -at-endo-online-2020-301072072.html> *

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CO2022017764A2 (es) 2023-04-27
MA58993A1 (fr) 2023-09-27
DOP2022000277A (es) 2023-04-16
JP2023531164A (ja) 2023-07-21
JOP20220329A1 (ar) 2022-12-04
CA3181084A1 (en) 2021-12-16
PH12022553389A1 (en) 2024-03-25
BR112022024875A2 (pt) 2022-12-27
EP4164636A1 (en) 2023-04-19
TWI911229B (zh) 2026-01-11
ECSP22092977A (es) 2023-03-31
MX2022015159A (es) 2023-03-01
PE20240544A1 (es) 2024-03-19
KR20230038458A (ko) 2023-03-20
CR20220624A (es) 2023-07-06
US20230255942A1 (en) 2023-08-17
TW202214235A (zh) 2022-04-16
IL298901A (en) 2023-02-01
WO2021252669A1 (en) 2021-12-16
AU2021286565A1 (en) 2023-02-02
CL2022003437A1 (es) 2023-05-26

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