JP2023530408A5 - - Google Patents

Info

Publication number
JP2023530408A5
JP2023530408A5 JP2022575800A JP2022575800A JP2023530408A5 JP 2023530408 A5 JP2023530408 A5 JP 2023530408A5 JP 2022575800 A JP2022575800 A JP 2022575800A JP 2022575800 A JP2022575800 A JP 2022575800A JP 2023530408 A5 JP2023530408 A5 JP 2023530408A5
Authority
JP
Japan
Application number
JP2022575800A
Other languages
Japanese (ja)
Other versions
JPWO2021252804A5 (https=
JP2023530408A (ja
JP7824894B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/036879 external-priority patent/WO2021252804A1/en
Publication of JP2023530408A publication Critical patent/JP2023530408A/ja
Publication of JPWO2021252804A5 publication Critical patent/JPWO2021252804A5/ja
Publication of JP2023530408A5 publication Critical patent/JP2023530408A5/ja
Application granted granted Critical
Publication of JP7824894B2 publication Critical patent/JP7824894B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022575800A 2020-06-12 2021-06-10 Cd70指向性がん免疫療法のための遺伝子修飾されたナチュラルキラー細胞 Active JP7824894B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063038645P 2020-06-12 2020-06-12
US63/038,645 2020-06-12
US202063090041P 2020-10-09 2020-10-09
US63/090,041 2020-10-09
US202163141411P 2021-01-25 2021-01-25
US63/141,411 2021-01-25
US202163201490P 2021-04-30 2021-04-30
US63/201,490 2021-04-30
PCT/US2021/036879 WO2021252804A1 (en) 2020-06-12 2021-06-10 Genetically modified natural killer cells for cd70-directed cancer immunotherapy

Publications (4)

Publication Number Publication Date
JP2023530408A JP2023530408A (ja) 2023-07-18
JPWO2021252804A5 JPWO2021252804A5 (https=) 2024-06-14
JP2023530408A5 true JP2023530408A5 (https=) 2024-06-14
JP7824894B2 JP7824894B2 (ja) 2026-03-05

Family

ID=78846545

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022575800A Active JP7824894B2 (ja) 2020-06-12 2021-06-10 Cd70指向性がん免疫療法のための遺伝子修飾されたナチュラルキラー細胞

Country Status (10)

Country Link
US (2) US12012458B2 (https=)
EP (1) EP4165171A4 (https=)
JP (1) JP7824894B2 (https=)
KR (1) KR20230024984A (https=)
AU (1) AU2021286655A1 (https=)
BR (1) BR112022025295A2 (https=)
CA (1) CA3184752A1 (https=)
IL (1) IL298510A (https=)
MX (1) MX2022015586A (https=)
WO (1) WO2021252804A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
KR102660336B1 (ko) 2017-03-27 2024-04-26 내셔널 유니버시티 오브 싱가포르 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도
AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
CN112055717B (zh) 2018-04-02 2024-04-26 新加坡国立大学 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
WO2021252804A1 (en) 2020-06-12 2021-12-16 Nkarta, Inc. Genetically modified natural killer cells for cd70-directed cancer immunotherapy
EP4232465A4 (en) * 2020-10-26 2024-10-23 Memorial Sloan Kettering Cancer Center Cells with cd70 knockout and uses for immunotherapy
CA3201499A1 (en) * 2020-11-13 2022-05-19 Catamaran Bio, Inc. Genetically modified natural killer cells and methods of use thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
JP2023552998A (ja) * 2020-12-03 2023-12-20 ンカルタ・インコーポレイテッド 効力および持続性の増強のために免疫細胞を操作する方法、ならびに免疫療法における操作された細胞の使用
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
EP4277638A4 (en) * 2021-01-12 2024-12-04 Hadasit Medical Research Services&Development Ltd. ENHANCED ADOPTIVE CELL TRANSFER THERAPY FOR CANCER
WO2023154785A2 (en) * 2022-02-10 2023-08-17 Orionis Biosciences, Inc. Il-2 trap molecules
CA3254363A1 (en) * 2022-03-07 2023-09-14 Nkarta, Inc. Multiplex gene-edited cells for CD70-led cancer immunotherapy
CN115925923B (zh) * 2022-09-26 2023-09-15 吉林大学 一种催化Aβ42寡聚体降解的单链抗体、单链抗体基因及其应用
US12311033B2 (en) 2023-05-31 2025-05-27 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
CN116445416B (zh) * 2023-06-08 2023-10-17 山东兴瑞生物科技有限公司 一种基因修饰的car-nk细胞及其制备方法和应用
WO2024251290A1 (en) * 2023-06-09 2024-12-12 Suzhou Cure Genetics Biosciences Co., Limited Engineered immune cells and uses thereof
WO2025038637A1 (en) * 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
TW202515994A (zh) * 2023-08-14 2025-04-16 美商英特利亞醫療公司 用於對cd70進行基因修飾之組合物及方法
AU2024324870A1 (en) * 2023-08-14 2026-02-12 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030022311A1 (en) 1996-05-21 2003-01-30 Dunnington Damien D. Human CIS protein
US6323317B1 (en) 1996-11-01 2001-11-27 The Walter And Eliza Hall Institute Of Medical Research Therapeutic and diagnostics proteins comprising a SOCS box
AU7267398A (en) 1997-04-30 1998-11-24 Hans Klingemann Natural killer cell lines and methods of use
EP1958962A3 (en) 1997-06-12 2013-05-01 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
CA2480052A1 (en) * 2002-04-01 2003-10-16 Human Genome Sciences, Inc. Antibodies that specifically bind to gmad
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US20050271660A1 (en) 2002-09-06 2005-12-08 Alexion Pharmaceuticals, Inc. Nebulization of monoclonal antibodies for treating pulmonary diseases
JP2008522951A (ja) 2004-07-19 2008-07-03 ベイラー・カレツジ・オブ・メデイシン サイトカインシグナル伝達調節物質の調節および免疫療法のための応用
US7863240B2 (en) 2004-10-08 2011-01-04 Enzo Therapeutics, Inc. Methods and uses of leptin in hepatocellular carcinoma
US7868159B2 (en) 2005-06-23 2011-01-11 Baylor College Of Medicine Modulation of negative immune regulators and applications for immunotherapy
EP1940460A4 (en) * 2005-10-27 2009-08-12 Biogen Idec Inc OLIGOD DRO CYTEN MYELIN GLYCOPROTEIN COMPOSITIONS AND USES THEREOF
WO2008060331A2 (en) * 2006-05-19 2008-05-22 Amgen Inc. Antibodies to sars coronavirus
DK2356270T3 (da) 2008-11-07 2016-12-12 Fabrus Llc Kombinatoriske antistofbiblioteker og anvendelser deraf
US20120192298A1 (en) 2009-07-24 2012-07-26 Sigma Aldrich Co. Llc Method for genome editing
WO2012078540A1 (en) 2010-12-08 2012-06-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulating immune cell activity using cytokine-induced src homology 2 and/or high temperature requirement a-1
EP4303232A3 (en) 2013-02-15 2024-04-17 The Regents of The University of California Chimeric antigen receptor and methods of use thereof
CA2932547C (en) * 2014-01-06 2023-05-23 F. Hoffmann-La Roche Ag Monovalent blood brain barrier shuttle modules
ES3063961T3 (en) * 2014-02-14 2026-04-21 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
MX373460B (es) 2014-03-11 2020-04-07 Cellectis Metodo para generar celulas t compatibles para el trasplante alogenico.
AU2015259877B2 (en) * 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
WO2015187521A2 (en) * 2014-06-03 2015-12-10 Merck Sharp & Dohme Corp. Anti-blys antibodies
AU2015360502A1 (en) 2014-12-10 2017-06-29 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
CA2976089C (en) 2015-02-10 2026-01-13 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies
US10100118B2 (en) * 2015-04-08 2018-10-16 Sorrento Therapeutics, Inc. Antibody therapeutics that bind CD123
CA2997444A1 (en) * 2015-09-29 2017-04-06 Amgen Inc. Asgr inhibitors for reducing cholesterol levels
KR102438360B1 (ko) 2016-03-04 2022-08-31 에디타스 메디신, 인코포레이티드 암 면역요법을 위한 crispr-cpf1-관련 방법, 조성물 및 구성성분
EP3519443A4 (en) 2016-09-30 2020-06-10 Baylor College of Medicine CHIMERIC ANTIGEN RECEPTOR THERAPY WITH REDUCED CYTOTOXICITY FOR VIRAL DISEASE
CA3041831A1 (en) 2016-10-27 2018-05-03 Intima Bioscience, Inc. Viral methods of making genetically modified cells
US20230192896A1 (en) * 2016-11-23 2023-06-22 Bioverativ Therapeutics Inc. Bispecific antibodies binding to coagulation factor ix and coagulation factor x
US20180100016A1 (en) 2016-12-22 2018-04-12 Xiaotong Song Use of car-modified human natural killer cells to treat cancer
CN118271442A (zh) * 2016-12-23 2024-07-02 蓝鳍生物医药公司 抗sez6l2抗体和抗体药物缀合物
JP2020503043A (ja) 2016-12-30 2020-01-30 セルラリティ インコーポレイテッド 遺伝子改変されたナチュラルキラー細胞
KR102660336B1 (ko) 2017-03-27 2024-04-26 내셔널 유니버시티 오브 싱가포르 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
US11497768B2 (en) * 2017-06-05 2022-11-15 Mie University Antigen-binding protein that recognizes MAGE-A4-derived peptide
SG11201912010XA (en) * 2017-06-12 2020-01-30 Obsidian Therapeutics Inc Pde5 compositions and methods for immunotherapy
WO2019006418A2 (en) * 2017-06-30 2019-01-03 Intima Bioscience, Inc. ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
CN111788301A (zh) * 2017-11-24 2020-10-16 昂克治疗有限公司 靶向肿瘤细胞的经修饰的自然杀伤细胞和自然杀伤细胞系
KR102780406B1 (ko) * 2018-02-01 2025-03-17 화이자 인코포레이티드 Cd70을 표적으로 하는 키메라 항원 수용체
MX2020009272A (es) 2018-03-06 2021-01-08 Univ Pennsylvania Receptores de antígeno quimérico del antígeno de membrana específico de próstata y métodos de uso de los mismos.
CN110351878B (zh) * 2018-04-04 2023-07-14 华为技术有限公司 一种随机接入处理方法和相关设备
US12227763B2 (en) 2018-05-11 2025-02-18 Crispr Therapeutics Ag Methods and compositions for treating cancer
JP2021530223A (ja) * 2018-07-09 2021-11-11 スロゼン, インコーポレイテッド 組織特異性Wntシグナル増強分子及びその使用
US20210338727A1 (en) * 2018-09-13 2021-11-04 Nkarta, Inc. Natural killer cell compositions and immunotherapy methods for treating tumors
JP7629414B2 (ja) 2019-06-04 2025-02-13 ンカルタ・インコーポレイテッド 免疫療法のための操作されたナチュラルキラー細胞と操作されたt細胞の組み合わせ
CA3144871A1 (en) 2019-06-27 2020-12-30 Crispr Therapeutics Ag Use of chimeric antigen receptor t cells and nk cell inhibitors for treating cancer
US12344656B2 (en) 2019-09-06 2025-07-01 Crispr Therapeutics Ag Genetically engineered T cells having improved persistence in culture
IL292467A (en) 2019-11-13 2022-06-01 Crispr Therapeutics Ag Treatment of hematopoietic cell cancers using genetically engineered t cells targeting cd70
BR112022009137A2 (pt) 2019-11-13 2022-07-26 Crispr Therapeutics Ag Métodos de fabricação de células t com receptor de antígeno quimérico (car)
BR112022009204A2 (pt) 2019-11-13 2022-07-26 Crispr Therapeutics Ag Terapia de carcinoma de células renais (rcc) usando células t geneticamente manipuladas visando cd70
KR20220119038A (ko) 2019-11-25 2022-08-26 케이에스큐 세러퓨틱스 인코포레이티드 종양 침윤 림프구의 활성화 및 확장을 위한 방법
CN115297890A (zh) 2020-02-03 2022-11-04 国立大学法人东海国立大学机构 用于对患癌的对象处置癌的抗meflin抗体和含有该抗体的药物组合物
WO2021231773A1 (en) * 2020-05-13 2021-11-18 Good Therapeutics, Inc. Compositions of protein complexes and methods of use thereof
WO2021252804A1 (en) 2020-06-12 2021-12-16 Nkarta, Inc. Genetically modified natural killer cells for cd70-directed cancer immunotherapy
JP2023536818A (ja) 2020-07-29 2023-08-30 ヤンセン バイオテツク,インコーポレーテツド Hla-g抗原結合ドメインを含むタンパク質及びそれらの使用
CN116322716A (zh) 2020-09-23 2023-06-23 克里斯珀医疗股份公司 Regnase-1和/或TGFBRII被破坏的基因工程化T细胞具有改善的功能性和持久性
JP2023552998A (ja) * 2020-12-03 2023-12-20 ンカルタ・インコーポレイテッド 効力および持続性の増強のために免疫細胞を操作する方法、ならびに免疫療法における操作された細胞の使用
AR125852A1 (es) 2021-05-12 2023-08-16 Crispr Therapeutics Ag Células inmunes modificadas genéticamente que se focalizan en cd70 para su uso en tratamiento de tumores sólidos
WO2022238962A1 (en) 2021-05-12 2022-11-17 Crispr Therapeutics Ag Genetically engineered immune cells targeting cd70 for use in treating hematopoietic malignancies
CA3254363A1 (en) 2022-03-07 2023-09-14 Nkarta, Inc. Multiplex gene-edited cells for CD70-led cancer immunotherapy

Similar Documents

Publication Publication Date Title
BR112023005462A2 (https=)
BR112023012656A2 (https=)
BR112023009656A2 (https=)
BR112022024743A2 (https=)
BR112022026905A2 (https=)
BR112023011738A2 (https=)
BR112023004146A2 (https=)
BR112023006729A2 (https=)
BR102021015500A2 (https=)
BR102021007058A2 (https=)
BR102020022030A2 (https=)
BR112023016292A2 (https=)
BR112023011539A2 (https=)
BR112023011610A2 (https=)
BR112023008976A2 (https=)
BR102021015450A8 (https=)
BR102021015247A2 (https=)
BR102021015220A2 (https=)
BR102021014044A2 (https=)
BR102021014056A2 (https=)
BR102021013929A2 (https=)
BR102021012571A2 (https=)
BR102021012230A2 (https=)
BR102021012003A2 (https=)
BR102021012107A2 (https=)