JP2023529828A5 - - Google Patents

Info

Publication number
JP2023529828A5
JP2023529828A5 JP2022574179A JP2022574179A JP2023529828A5 JP 2023529828 A5 JP2023529828 A5 JP 2023529828A5 JP 2022574179 A JP2022574179 A JP 2022574179A JP 2022574179 A JP2022574179 A JP 2022574179A JP 2023529828 A5 JP2023529828 A5 JP 2023529828A5
Authority
JP
Japan
Prior art keywords
compound
treprostinyl
fdkp
formula
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022574179A
Other languages
English (en)
Japanese (ja)
Other versions
JP7608480B2 (ja
JP2023529828A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/036335 external-priority patent/WO2021252446A1/en
Publication of JP2023529828A publication Critical patent/JP2023529828A/ja
Publication of JP2023529828A5 publication Critical patent/JP2023529828A5/ja
Priority to JP2024221661A priority Critical patent/JP2025041731A/ja
Application granted granted Critical
Publication of JP7608480B2 publication Critical patent/JP7608480B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022574179A 2020-06-09 2021-06-08 トレプロスチニルのフマリルジケトピペリジンプロドラッグ Active JP7608480B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024221661A JP2025041731A (ja) 2020-06-09 2024-12-18 トレプロスチニルのフマリルジケトピペリジンプロドラッグ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063036561P 2020-06-09 2020-06-09
US63/036,561 2020-06-09
PCT/US2021/036335 WO2021252446A1 (en) 2020-06-09 2021-06-08 Fumaryl diketopiperidine prodrugs of treprostinil

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024221661A Division JP2025041731A (ja) 2020-06-09 2024-12-18 トレプロスチニルのフマリルジケトピペリジンプロドラッグ

Publications (3)

Publication Number Publication Date
JP2023529828A JP2023529828A (ja) 2023-07-12
JP2023529828A5 true JP2023529828A5 (https=) 2024-06-17
JP7608480B2 JP7608480B2 (ja) 2025-01-06

Family

ID=76731024

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022574179A Active JP7608480B2 (ja) 2020-06-09 2021-06-08 トレプロスチニルのフマリルジケトピペリジンプロドラッグ
JP2024221661A Pending JP2025041731A (ja) 2020-06-09 2024-12-18 トレプロスチニルのフマリルジケトピペリジンプロドラッグ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024221661A Pending JP2025041731A (ja) 2020-06-09 2024-12-18 トレプロスチニルのフマリルジケトピペリジンプロドラッグ

Country Status (9)

Country Link
US (3) US11793780B2 (https=)
EP (1) EP4161909A1 (https=)
JP (2) JP7608480B2 (https=)
KR (2) KR20250057075A (https=)
CN (1) CN116113415A (https=)
AU (2) AU2021289336B2 (https=)
CA (1) CA3180230A1 (https=)
IL (1) IL298591A (https=)
WO (1) WO2021252446A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024510930A (ja) 2021-03-03 2024-03-12 ユナイテッド セラピューティクス コーポレイション トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物
WO2023154705A1 (en) 2022-02-08 2023-08-17 United Therapeutics Corporation Treprostinil iloprost combination therapy

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2485614A (en) 1946-08-29 1949-10-25 Chicago Bridge & Iron Co Stabilizing and guide apparatus for lifter roofs
US3037116A (en) 1957-07-26 1962-05-29 Weber Georges Apparatus for irradiating liquids
US3035516A (en) 1958-08-18 1962-05-22 Lee Brothers Company Stencil device
US3646509A (en) 1969-08-08 1972-02-29 Texas Instruments Inc Method for field stacking seismic data and system using write after read bulk data storage
US4306075A (en) 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US4547016A (en) 1984-08-13 1985-10-15 Eeco Incorporated Quick release mounting
GB8814438D0 (en) 1988-06-17 1988-07-20 Wellcome Found Compounds for use in medicine
IT1231076B (it) 1989-09-28 1991-11-12 Pirelli Cavi Spa Procedimento per la realizzazione di gruppo di connessione separabile per fibre ottiche riunite a nastro e gruppo di connessione con esso realizzato.
GB9011588D0 (en) 1990-05-24 1990-07-11 Wellcome Found Prostaglandin analogues for use in medicine
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
KR100638684B1 (ko) 1997-11-14 2006-10-27 유나이티드 세러퓨틱스 코오포레이션 말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도
US6521212B1 (en) 1999-03-18 2003-02-18 United Therapeutics Corporation Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
CA2359652A1 (en) 1999-03-31 2000-10-05 United Therapeutics Corporation Novel prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of peripheral vascular disease and pulmonaryhypertension
US6700025B2 (en) 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
US6803386B2 (en) 2002-01-16 2004-10-12 United Therapeutics Corporation Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
US6756117B1 (en) 2002-12-20 2004-06-29 The United States Of America As Represented By The United States Department Of Energy Photonic polymer-blend structures and method for making
ES2622471T5 (es) 2003-05-22 2020-07-23 United Therapeutics Corp Compuestos y procedimientos para la administración de análogos de prostaciclina
US20090124697A1 (en) 2003-12-16 2009-05-14 United Therapeutics Corporation Inhalation formulations of treprostinil
DE602004028155D1 (de) 2003-12-16 2010-08-26 United Therapeutics Corp Verwendung von treprostinil zur behandlung von ischämischen läsionen
ATE441418T1 (de) 2003-12-16 2009-09-15 United Therapeutics Corp Verwendung von treprostinil zur verbesserung der nierenfunktion
WO2005099680A2 (en) 2004-04-12 2005-10-27 United Therapeutics, Inc. Use of treprostinil to treat neuropathic diabetic foot ulcers
US8747897B2 (en) 2006-04-27 2014-06-10 Supernus Pharmaceuticals, Inc. Osmotic drug delivery system
EP2026816B1 (en) 2006-05-15 2018-10-24 United Therapeutics Corporation Treprostinil administration using a metered dose inhaler
US20090036465A1 (en) 2006-10-18 2009-02-05 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
JP2010518122A (ja) 2007-02-09 2010-05-27 ユナイテッド セラピューティクス コーポレーション 間質性肺疾患および喘息のためのトレプロスチニル処置
CN103181893A (zh) 2007-09-07 2013-07-03 联合治疗公司 针对革兰氏阴性细菌具有选择性杀菌活性的缓冲液及其使用方法
CN101903324B (zh) 2007-12-17 2013-07-03 联合治疗公司 一种制备Remodulin中的活性成分曲前列素的改良方法
CA2723540C (en) 2008-05-08 2016-01-05 United Therapeutics Corporation Treprostinil monohydrate
US8349892B2 (en) 2009-05-07 2013-01-08 United Therapeutics Corporation Solid formulations of prostacyclin analogs
US8642548B2 (en) * 2009-08-07 2014-02-04 Mannkind Corporation Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome
RS53234B (sr) 2009-08-07 2014-08-29 Scipharm Sàrl Kompozicija za lečenje cistične fibroze
ES2611187T3 (es) 2010-03-15 2017-05-05 United Therapeutics Corporation Tratamiento para hipertensión pulmonar
JP6046034B2 (ja) 2010-06-03 2016-12-14 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの製造
CA2710726C (en) 2010-07-22 2016-02-23 Alphora Research Inc. Synthesis of treprostinil and intermediates useful therein
CA2710725C (en) 2010-07-22 2017-08-01 Alphora Research Inc. Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
CA2726599C (en) 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
US20130345471A1 (en) 2011-03-02 2013-12-26 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
MX349950B (es) * 2011-08-12 2017-08-22 Ascendis Pharma As Profarmacos de treprostinil enlazados a un portador.
US9388154B2 (en) 2011-09-12 2016-07-12 Lund Biotechnology PBC Process for preparing synthetic prostacyclins
CN103193626B (zh) 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
CN103193627B (zh) 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
US9387214B2 (en) 2012-01-13 2016-07-12 United Therapeutics Corporation Method of identifying therapies for pulmonary hypertension
LT2674413T (lt) 2012-06-15 2017-09-25 Scipharm Sąrl Treprostinilo ir jo darinių gavimo būdas
AU2013351934B2 (en) 2012-11-30 2018-03-29 Insmed Incorporated Prostacylin compositions and methods for using the same
CN104837806A (zh) 2012-12-07 2015-08-12 开曼化学股份有限公司 前列环素类似物的合成方法
EP3712142B1 (en) 2013-01-11 2022-07-06 Corsair Pharma, Inc. Prodrugs of treprostinil
JP2016517410A (ja) 2013-03-14 2016-06-16 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの固体形態
CN109608326A (zh) 2013-03-15 2019-04-12 联合治疗公司 曲前列环素的盐
JP6263604B2 (ja) * 2013-03-25 2018-01-17 ユナイテッド セラピューティクス コーポレイション チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法
US9758465B2 (en) 2013-04-30 2017-09-12 United Therapeutics Corporation Controlled release pharmaceutical formulations
ES2860975T3 (es) 2013-10-25 2021-10-05 Insmed Inc Compuestos de prostaciclina
TWI685348B (zh) 2014-05-08 2020-02-21 美國禮來大藥廠 速效胰島素組合物
CN105723505B (zh) 2014-05-14 2019-03-08 富士电机株式会社 半导体装置及半导体装置的制造方法
ES2908142T3 (es) 2014-06-13 2022-04-27 United Therapeutics Corp Formulaciones de treprostinil
US20160045470A1 (en) 2014-08-12 2016-02-18 Dr. Reddy's Laboratories Limited Amorphous solid dispersion of treprostinil diethanolamine
WO2016038532A1 (en) 2014-09-09 2016-03-17 Mylan Laboratories Limited Amorphous treprostinil diethanolamine
HU231186B1 (hu) 2014-10-08 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás treprostinil és sói előállítására
US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives
AU2015349969B2 (en) 2014-11-18 2020-02-06 Insmed Incorporated Methods of manufacturing treprostinil and treprostinil derivative prodrugs
TWI540121B (zh) 2014-12-01 2016-07-01 臺灣永光化學工業股份有限公司 曲前列環素二乙醇胺之合成方法及新穎中間體
US10837038B2 (en) 2014-12-23 2020-11-17 National Technology & Engineering Solutions Of Sandia, Llc Adjusting the pH of a pretreatment solution using carbon dioxide useful for integrating saccharification and fermentation
CA3012679C (en) 2016-01-29 2023-12-12 Mannkind Corporation Dry powder inhaler
JP7220650B2 (ja) 2016-09-26 2023-02-10 ユナイテッド セラピューティクス コーポレイション トレプロスチニルプロドラッグ
EP3498283A1 (en) * 2017-12-14 2019-06-19 Ipsol AG Glycosidic derivatives of treprostinil
CA3102967A1 (en) * 2018-06-07 2019-12-12 Mannkind Corporation Composition and method for inhalation

Similar Documents

Publication Publication Date Title
CA2908244C (en) Process of making prostacyclin compounds with linker thiol and pegylated forms
CN1582272A (zh) 制备5－(3－氰基苯基)－3－甲酰基苯甲酸化合物的方法
JP2023529828A5 (https=)
CN1060778C (zh) 头孢菌素衍生物
CN1137892C (zh) N-9取代的鸟嘌呤化合物的制备
CN1247573C (zh) 制备芳基乙酰基氨基噻唑的方法
CN1029965C (zh) 具有氨基噻唑(亚氨基氧基乙酸)乙酸侧链的β-内酰胺的制备方法
MXPA02001396A (es) Proceso para la preparacion de un analogo de carbonato de metilo del carbono 4, del paclitaxel.
CN1036712C (zh) 抗病毒剂[1R-(1α，2β，3α)]-2-氨基-9-[2，3-双(羟甲基)环丁基]-1，9-二氢-6H-嘌呤-6-酮的制备方法
WO2011104540A1 (en) One step process for the preparation of capecitabine
CN1835918A (zh) 外消旋2－{[2－(4－羟基苯基)乙基]硫基}－3－[4－(2－{4－[(甲磺酰基)氧基]苯氧基}乙基)苯基]－丙酸的制备方法
CN1064683C (zh) 制备嘌呤衍生物的方法
JP2023541840A5 (https=)
CN1314685C (zh) 2,6－二卤代嘌呤的制备方法
CN1257166C (zh) 制备具有抗组胺活性的三环化合物的方法
CN1269783A (zh) 一种制备环氧化物中间体的方法
US20030149284A1 (en) Method of synthesizing a paclitaxel derivative
CN101044130A (zh) 一种制备缩水甘油衍生物的方法
JP4163113B2 (ja) 新規化合物及びその製造方法
JP4829418B2 (ja) 光学活性なハロヒドリン誘導体およびその使用方法
EP3445745B1 (en) Process for the preparation of bimatoprost
CN1383430A (zh) 胞苷衍生物的生产方法
CN1740155A (zh) 选择性合成氟伐他汀的中间体及其制备方法和用途
CN1547582A (zh) 改进的支化无环核苷的合成
US20090163513A1 (en) Process for ziprasidone using novel intermediates