JP2023529457A5 - - Google Patents

Info

Publication number
JP2023529457A5
JP2023529457A5 JP2022575711A JP2022575711A JP2023529457A5 JP 2023529457 A5 JP2023529457 A5 JP 2023529457A5 JP 2022575711 A JP2022575711 A JP 2022575711A JP 2022575711 A JP2022575711 A JP 2022575711A JP 2023529457 A5 JP2023529457 A5 JP 2023529457A5
Authority
JP
Japan
Prior art keywords
polynucleotide
polynucleotide according
guanosine
guanosine analog
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022575711A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023529457A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2021/065266 external-priority patent/WO2021249993A1/en
Publication of JP2023529457A publication Critical patent/JP2023529457A/ja
Publication of JP2023529457A5 publication Critical patent/JP2023529457A5/ja
Pending legal-status Critical Current

Links

JP2022575711A 2020-06-09 2021-06-08 治療用ポリヌクレオチドに使用するためのグアノシン類似体 Pending JP2023529457A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20179011 2020-06-09
EP20179011.0 2020-06-09
PCT/EP2021/065266 WO2021249993A1 (en) 2020-06-09 2021-06-08 Guanosine analogues for use in therapeutic polynucleotides

Publications (2)

Publication Number Publication Date
JP2023529457A JP2023529457A (ja) 2023-07-10
JP2023529457A5 true JP2023529457A5 (https=) 2024-06-14

Family

ID=71083397

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022575711A Pending JP2023529457A (ja) 2020-06-09 2021-06-08 治療用ポリヌクレオチドに使用するためのグアノシン類似体

Country Status (5)

Country Link
US (1) US20230212572A1 (https=)
EP (1) EP4162047A1 (https=)
JP (1) JP2023529457A (https=)
CN (1) CN115702243A (https=)
WO (1) WO2021249993A1 (https=)

Family Cites Families (33)

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JP4236812B2 (ja) 1997-09-12 2009-03-11 エクシコン エ/エス オリゴヌクレオチド類似体
ES2234563T5 (es) 1999-02-12 2018-01-17 Daiichi Sankyo Company, Limited Nuevos análogos de nucleósidos y oligonucleótidos
US7053207B2 (en) 1999-05-04 2006-05-30 Exiqon A/S L-ribo-LNA analogues
US6617442B1 (en) 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
EP1272630A2 (en) 2000-03-16 2003-01-08 Genetica, Inc. Methods and compositions for rna interference
ES2336887T5 (es) 2000-03-30 2019-03-06 Whitehead Inst Biomedical Res Mediadores de interferencia por ARN específicos de secuencias de ARN
WO2004046160A2 (en) 2002-11-18 2004-06-03 Santaris Pharma A/S Amino-lna, thio-lna and alpha-l-oxy-ln
WO2007090071A2 (en) 2006-01-27 2007-08-09 Isis Pharmaceuticals, Inc. 6-modified bicyclic nucleic acid analogs
AU2007249349B2 (en) 2006-05-11 2012-03-08 Isis Pharmaceuticals, Inc. 5'-Modified bicyclic nucleic acid analogs
US7666854B2 (en) 2006-05-11 2010-02-23 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
CA2688321A1 (en) 2007-05-30 2008-12-11 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
DK2173760T4 (en) 2007-06-08 2016-02-08 Isis Pharmaceuticals Inc Carbocyclic bicyclic nukleinsyreanaloge
AU2008272918B2 (en) 2007-07-05 2012-09-13 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
WO2009067647A1 (en) 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Carbocyclic alpha-l-bicyclic nucleic acid analogs
US8541569B2 (en) * 2008-09-06 2013-09-24 Chemgenes Corporation Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
DK2356129T3 (da) 2008-09-24 2013-05-13 Isis Pharmaceuticals Inc Substituerede alpha-L-bicykliske nukleosider
US9012421B2 (en) 2009-08-06 2015-04-21 Isis Pharmaceuticals, Inc. Bicyclic cyclohexose nucleic acid analogs
EP2580228B1 (en) 2010-06-08 2016-03-23 Ionis Pharmaceuticals, Inc. Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
US10202599B2 (en) 2011-08-11 2019-02-12 Ionis Pharmaceuticals, Inc. Selective antisense compounds and uses thereof
WO2013151665A2 (en) * 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
EP2850092B1 (en) 2012-04-09 2017-03-01 Ionis Pharmaceuticals, Inc. Tricyclic nucleic acid analogs
CN104837996A (zh) 2012-11-15 2015-08-12 罗氏创新中心哥本哈根有限公司 抗apob反义缀合物化合物
EP2754714A1 (en) * 2013-01-14 2014-07-16 Sarepta Therapeutics, Inc. Inhibitory oligonucleotides and their use in therapy
CA2935426C (en) 2014-01-30 2023-07-25 F. Hoffmann-La Roche Ag Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target
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