JP2023529065A - Hpv由来の免疫原性フラグメントのためのの担体としてのナノ粒子の組成物 - Google Patents
Hpv由来の免疫原性フラグメントのためのの担体としてのナノ粒子の組成物 Download PDFInfo
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- JP2023529065A JP2023529065A JP2022568723A JP2022568723A JP2023529065A JP 2023529065 A JP2023529065 A JP 2023529065A JP 2022568723 A JP2022568723 A JP 2022568723A JP 2022568723 A JP2022568723 A JP 2022568723A JP 2023529065 A JP2023529065 A JP 2023529065A
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- A61K39/385—Haptens or antigens, bound to carriers
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Chemical Kinetics & Catalysis (AREA)
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- Inorganic Chemistry (AREA)
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- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20174156.8A EP3909612A1 (en) | 2020-05-12 | 2020-05-12 | Composition of nanoparticles |
| EP20174156.8 | 2020-05-12 | ||
| EP20196027.5 | 2020-09-14 | ||
| EP20196027.5A EP3909614A1 (en) | 2020-05-12 | 2020-09-14 | Composition of nanoparticles as carrier for hpv-derived immunogenic fragments |
| PCT/EP2021/062748 WO2021229014A1 (en) | 2020-05-12 | 2021-05-12 | Composition of nanoparticles as carrier for hpv-derived immunogenic fragments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023529065A true JP2023529065A (ja) | 2023-07-07 |
| JP2023529065A5 JP2023529065A5 (cg-RX-API-DMAC7.html) | 2024-05-22 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022568723A Pending JP2023529065A (ja) | 2020-05-12 | 2021-05-12 | Hpv由来の免疫原性フラグメントのためのの担体としてのナノ粒子の組成物 |
| JP2022568554A Pending JP2023524874A (ja) | 2020-05-12 | 2021-05-12 | ナノ粒子の組成物 |
| JP2022568724A Pending JP2023529066A (ja) | 2020-05-12 | 2021-05-12 | アジュバント/抗原の担体系としてのナノ粒子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022568554A Pending JP2023524874A (ja) | 2020-05-12 | 2021-05-12 | ナノ粒子の組成物 |
| JP2022568724A Pending JP2023529066A (ja) | 2020-05-12 | 2021-05-12 | アジュバント/抗原の担体系としてのナノ粒子 |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US20240197909A1 (cg-RX-API-DMAC7.html) |
| EP (6) | EP3909612A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2023529065A (cg-RX-API-DMAC7.html) |
| WO (3) | WO2021229015A1 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023529066A (ja) * | 2020-05-12 | 2023-07-07 | ライフ サイエンス インクバトーア ベトリープス ゲーエムベーハー ウント コンパニー カーゲー | アジュバント/抗原の担体系としてのナノ粒子 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113274492B (zh) * | 2021-05-21 | 2022-06-17 | 大连理工大学 | 一种基于羟基氧化铝纳米羧基改性的复合疫苗佐剂的制备方法 |
| EP4547258A4 (en) * | 2022-06-28 | 2026-08-05 | Transcode Therapeutics Inc | Matrix-Directed Rig-I Agonitor Nanoparticles and Precursor Compositions and Their Uses in Cancer Therapy |
| EP4551242A4 (en) * | 2022-07-08 | 2026-06-24 | Mark C Poznansky | VACCINE CONTAINING A PROTEIN IMMUNE ADJUVANT |
| EP4673170A1 (en) * | 2023-03-02 | 2026-01-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | A therapeutic hpv vaccine based on validated target epitopes |
| CN120857941A (zh) * | 2023-03-02 | 2025-10-28 | 德国癌症研究公共权益基金会 | 经验证的hpv16衍生的刺激肽 |
| EP4673166A1 (en) * | 2023-03-02 | 2026-01-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Therapeutic hpv vaccines based on validated target epitopes |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011018499A1 (de) * | 2011-04-23 | 2012-10-25 | Emc Microcollections Gmbh | Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut |
| WO2015086354A2 (en) * | 2013-12-12 | 2015-06-18 | Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechtes | Novel promiscuous hpv16-derived t helper epitopes for immunotherapy |
| WO2017223085A2 (en) * | 2016-06-20 | 2017-12-28 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
| WO2018085751A1 (en) * | 2016-11-07 | 2018-05-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Development of agonist epitopes of the human papillomavirus |
| WO2019097226A1 (en) * | 2017-11-14 | 2019-05-23 | N4 Pharma Uk Limited | Particulate material production process |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3616133A1 (de) | 1985-09-25 | 1987-11-19 | Merck Patent Gmbh | Kugelfoermige sio(pfeil abwaerts)2(pfeil abwaerts)-partikel |
| US6419931B1 (en) * | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| ES2148259T3 (es) | 1993-09-22 | 2000-10-16 | Hoechst Ag | Pro-profarmacos, su produccion y uso. |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6180095B1 (en) | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| DE19912502A1 (de) * | 1999-03-19 | 2000-09-21 | Inst Neue Mat Gemein Gmbh | Nanoskalige Teilchen, Komplexe mit Polynukleotiden und deren Verwendung |
| IL148844A0 (en) | 1999-09-27 | 2002-09-12 | Coley Pharm Group Inc | Methods related to immunostimulatory nucleic acid-induced interferon |
| KR100919266B1 (ko) * | 2000-06-26 | 2009-09-30 | 엔벤타 바이오파마슈티컬스 코포레이션 | 인간 파필로마 바이러스 치료법 |
| DE102004011110A1 (de) | 2004-03-08 | 2005-09-22 | Merck Patent Gmbh | Verfahren zur Herstellung monodisperser SiO2-Partikel |
| US20060088599A1 (en) * | 2004-08-02 | 2006-04-27 | Prasad Paras N | Amino functionalized ORMOSIL nanoparticles as delivery vehicles |
| ES2625905T3 (es) | 2004-10-01 | 2017-07-20 | Midatech Ltd. | Nanopartículas que comprenden antígenos y adyuvantes capaces de estimular linfocitos T cooperadores |
| WO2006063252A2 (en) | 2004-12-09 | 2006-06-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering rnas |
| CN101160048A (zh) * | 2004-12-30 | 2008-04-09 | 哈达斯特医学研究服务与开发有限公司 | 形成非析出性持续抗微生物聚合组合物的抗微生物纳米颗粒添加剂 |
| WO2007031734A1 (en) | 2005-09-14 | 2007-03-22 | Ucb Pharma S.A. | Comb polymers |
| EP1764107A1 (en) | 2005-09-14 | 2007-03-21 | Gunther Hartmann | Compositions comprising immunostimulatory RNA oligonucleotides and methods for producing said RNA oligonucleotides |
| JP2010500011A (ja) | 2006-08-08 | 2010-01-07 | ガンサー ハートマン | 5’リン酸オリゴヌクレオチドの構造および使用 |
| FR2908305B1 (fr) | 2006-11-10 | 2009-02-27 | Oreal | Procede de deformation permanente des fibres keratiniques comprenant une etape d'application d'une composition de rincage intermediaire comprenant un sel de cation metallique monovalent ou un sel d'ammonium et un acide organique |
| JP5448369B2 (ja) * | 2008-05-15 | 2014-03-19 | 古河電気工業株式会社 | 粒子表面にアミノ基を有するシリカ粒子の製造方法、粒子表面にアミノ基を有するシリカ粒子、及びそれを用いた複合粒子 |
| DK2518150T3 (en) | 2008-05-21 | 2015-12-07 | Univ Bonn | 5'Trip phosphate triphosphate oligonucleotide and uses thereof |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| DE102008033175A1 (de) | 2008-07-15 | 2010-01-21 | Merck Patent Gmbh | Siliciumdioxid-Nanopartikel und deren Verwendung zur Vakzinierung |
| EP3263707A1 (en) | 2009-03-17 | 2018-01-03 | Rheinische Friedrich-Wilhelms-Universität Bonn | Tlr8 ligand and uses thereof |
| ES2366841B1 (es) * | 2010-04-06 | 2013-01-24 | Consejo Superior De Investigaciones Cientificas (Csic) (45%) | Nanoparticulas de silice para difusion intracelular de agentes bioactivos poco solubles |
| CN103002922B (zh) | 2010-06-10 | 2015-11-25 | Mida科技有限公司 | 携带肽的纳米颗粒 |
| BR112014005362A2 (pt) | 2011-09-07 | 2017-06-13 | Immunotope Inc | vacinas de tumor com nanopartículas |
| JP6077544B2 (ja) | 2011-09-07 | 2017-02-08 | ミダテック リミテッド | ナノ粒子−ペプチド組成物 |
| MA39909B1 (fr) | 2014-04-25 | 2019-05-31 | Pf Medicament | Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer |
| WO2016013751A1 (ko) * | 2014-07-22 | 2016-01-28 | 주식회사 레모넥스 | 생리활성 물질 또는 단백질 전달용 조성물 및 이의 용도 |
| US20160090603A1 (en) * | 2014-09-30 | 2016-03-31 | Sandia Corporation | Delivery platforms for the domestication of algae and plants |
| EP3370741B1 (en) * | 2015-11-04 | 2025-10-08 | The Trustees of the University of Pennsylvania | Methods and compositions for gene editing in hematopoietic stem cells |
| PT3319587T (pt) * | 2015-11-17 | 2019-11-20 | Bioncotech Therapeutics S L | Nova composição farmacêutica que compreende partículas compreendendo um complexo de um polirribonuleótido de cadeia dupla e uma polialquilenoimina |
| WO2019028387A1 (en) * | 2017-08-03 | 2019-02-07 | Rita Elena Serda | LIPOSOMAL COATED NANOPARTICLES FOR IMMUNOTHERAPY APPLICATIONS |
| US20210196838A1 (en) * | 2018-08-24 | 2021-07-01 | Mirexus Biotechnologies Inc. | Compounds and compositions for potentiation of tlr agonists |
| EP3909612A1 (en) * | 2020-05-12 | 2021-11-17 | Life Science Inkubator Betriebs GmbH & Co. KG | Composition of nanoparticles |
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2020
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2021
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- 2021-05-12 WO PCT/EP2021/062751 patent/WO2021229015A1/en not_active Ceased
- 2021-05-12 WO PCT/EP2021/062759 patent/WO2021229020A1/en not_active Ceased
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2025
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011018499A1 (de) * | 2011-04-23 | 2012-10-25 | Emc Microcollections Gmbh | Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut |
| WO2015086354A2 (en) * | 2013-12-12 | 2015-06-18 | Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechtes | Novel promiscuous hpv16-derived t helper epitopes for immunotherapy |
| WO2017223085A2 (en) * | 2016-06-20 | 2017-12-28 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
| WO2018085751A1 (en) * | 2016-11-07 | 2018-05-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Development of agonist epitopes of the human papillomavirus |
| WO2019097226A1 (en) * | 2017-11-14 | 2019-05-23 | N4 Pharma Uk Limited | Particulate material production process |
Non-Patent Citations (1)
| Title |
|---|
| INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 9, no. 2, JPN6025027036, 2014, pages 207 - 215, ISSN: 0005825796 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023529066A (ja) * | 2020-05-12 | 2023-07-07 | ライフ サイエンス インクバトーア ベトリープス ゲーエムベーハー ウント コンパニー カーゲー | アジュバント/抗原の担体系としてのナノ粒子 |
Also Published As
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| EP4149562A1 (en) | 2023-03-22 |
| EP4149560A1 (en) | 2023-03-22 |
| US20230272014A1 (en) | 2023-08-31 |
| US20260000754A1 (en) | 2026-01-01 |
| EP4149561A1 (en) | 2023-03-22 |
| US20230181727A1 (en) | 2023-06-15 |
| US20240197909A1 (en) | 2024-06-20 |
| EP3909612A1 (en) | 2021-11-17 |
| JP2023529066A (ja) | 2023-07-07 |
| JP2023524874A (ja) | 2023-06-13 |
| WO2021229014A1 (en) | 2021-11-18 |
| WO2021229015A1 (en) | 2021-11-18 |
| EP3909613A1 (en) | 2021-11-17 |
| WO2021229020A1 (en) | 2021-11-18 |
| EP3909614A1 (en) | 2021-11-17 |
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