JP2023528659A - Ｎｅｋ７キナーゼの阻害剤 - Google Patents

Ｎｅｋ７キナーゼの阻害剤 Download PDF

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Publication number
JP2023528659A
JP2023528659A JP2022575408A JP2022575408A JP2023528659A JP 2023528659 A JP2023528659 A JP 2023528659A JP 2022575408 A JP2022575408 A JP 2022575408A JP 2022575408 A JP2022575408 A JP 2022575408A JP 2023528659 A JP2023528659 A JP 2023528659A
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JP
Japan
Prior art keywords
compound
alkyl
mmol
alkenyl
optionally substituted
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JP2022575408A
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Japanese (ja)
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JP2023528659A5 (https=
Inventor
ジェームズ ベアス，デイビッド
ザ サード，ジョン サイ ケオン カウエ
ヘンリ アベル モラール，アレクシス
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Halia Therapeutics Inc
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Halia Therapeutics Inc
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Publication of JP2023528659A publication Critical patent/JP2023528659A/ja
Publication of JP2023528659A5 publication Critical patent/JP2023528659A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
JP2022575408A 2020-06-08 2021-06-08 Ｎｅｋ７キナーゼの阻害剤 Pending JP2023528659A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063036244P 2020-06-08 2020-06-08
US63/036,244 2020-06-08
US202163170776P 2021-04-05 2021-04-05
US63/170,776 2021-04-05
US202163185257P 2021-05-06 2021-05-06
US63/185,257 2021-05-06
PCT/US2021/036398 WO2021252488A1 (en) 2020-06-08 2021-06-08 Inhibitors of nek7 kinase

Publications (2)

Publication Number Publication Date
JP2023528659A true JP2023528659A (ja) 2023-07-05
JP2023528659A5 JP2023528659A5 (https=) 2024-06-13

Family

ID=76731040

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022575408A Pending JP2023528659A (ja) 2020-06-08 2021-06-08 Ｎｅｋ７キナーゼの阻害剤

Country Status (13)

Country Link
US (1) US20230203045A1 (https=)
EP (1) EP4161933A1 (https=)
JP (1) JP2023528659A (https=)
KR (1) KR20230035311A (https=)
CN (1) CN116075513A (https=)
AU (1) AU2021289345A1 (https=)
BR (1) BR112022025012A2 (https=)
CA (1) CA3186041A1 (https=)
CO (1) CO2022019131A2 (https=)
IL (1) IL298849A (https=)
MX (1) MX2022015495A (https=)
TW (1) TWI908811B (https=)
WO (1) WO2021252488A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS65962B1 (sr) 2020-05-08 2024-10-31 Halia Therapeutics Inc Inhibitori nek7 kinaze
US20240400551A1 (en) * 2021-01-25 2024-12-05 Halia Therapeutics, Inc. Nek7 inhibitors
US20240158394A1 (en) * 2022-09-14 2024-05-16 Halia Therapeutics, Inc. Nek7 inhibitors
WO2025140570A1 (zh) * 2023-12-29 2025-07-03 北京普祺医药科技股份有限公司 一种nek7抑制剂、药物组合物及其用途

Citations (4)

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JP2021520356A (ja) * 2018-04-05 2021-08-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｉｉ型ｉｒａｋ阻害剤としてのヘテロアリール化合物及びその使用
JP2021534150A (ja) * 2017-08-10 2021-12-09 インフレイゾーム リミテッド 新規スルホンウレア化合物
JP2022550070A (ja) * 2019-09-26 2022-11-30 深▲チェン▼市塔吉瑞生物医薬有限公司 置換された縮合芳香環誘導体、その組成物、およびそれらの使用
JP2023518035A (ja) * 2020-03-16 2023-04-27 フラッシュ セラピューティクス，エルエルシー 急性骨髄性白血病の再発を処置または阻害するための化合物

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US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
MXPA03008560A (es) 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
US20110189167A1 (en) 2007-04-20 2011-08-04 Flynn Daniel L Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
UY33288A (es) 2010-03-25 2011-10-31 Glaxosmithkline Llc Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico
EP2802212B1 (en) 2012-01-12 2015-12-30 Basf Se Herbicidal isoxazolo[5,4-b]pyridines
CN105017256A (zh) 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
RU2724345C2 (ru) 2015-10-09 2020-06-23 Галапагос Нв N-СУЛЬФОНИЛИРОВАННЫЕ ПИРАЗОЛО[3,4-b]ПИРИДИН-6-КАРБОКСАМИДЫ И СПОСОБ ИХ ПРИМЕНЕНИЯ
CN108250200A (zh) 2016-12-28 2018-07-06 中国科学院上海药物研究所 一种具有Axl抑制活性的化合物及其制备和应用
DE102017200543A1 (de) 2017-01-13 2018-07-19 Baden-Württemberg Stiftung Ggmbh Verfahren zur Behandlung einer Oberfläche eines Hartmetallkörpers und zur Beschichtung des behandelten Hartmetallkörpers mit einer Diamantschicht
MX2020001776A (es) * 2017-08-15 2020-03-24 Inflazome Ltd Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3.
KR20200087759A (ko) 2017-11-09 2020-07-21 인플라좀 리미티드 신규한 설폰아마이드 카복스아마이드 화합물
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CN111646995B (zh) * 2019-03-04 2023-03-21 四川大学 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021534150A (ja) * 2017-08-10 2021-12-09 インフレイゾーム リミテッド 新規スルホンウレア化合物
JP2021520356A (ja) * 2018-04-05 2021-08-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｉｉ型ｉｒａｋ阻害剤としてのヘテロアリール化合物及びその使用
JP2022550070A (ja) * 2019-09-26 2022-11-30 深▲チェン▼市塔吉瑞生物医薬有限公司 置換された縮合芳香環誘導体、その組成物、およびそれらの使用
JP2023518035A (ja) * 2020-03-16 2023-04-27 フラッシュ セラピューティクス，エルエルシー 急性骨髄性白血病の再発を処置または阻害するための化合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EDUARDO MORAES ET AL.: ""Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for I", MOLECULES, vol. 20, no. 1, JPN6025030542, 13 January 2015 (2015-01-13), pages 1176 - 1191, ISSN: 0005651410 *
JIN XU ET AL.: ""NEK7: a novel promising therapy target for NLRP3-related inflammatory diseases"", ACTA BIOCHIMICA ET BIOPHYSICA SINICA, vol. 48, no. 10, JPN6025030541, 1 October 2016 (2016-10-01), pages 966 - 968, ISSN: 0005651409 *
MATTHEW J. BYRNE ET AL.: ""Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-", BIOCHEMICAL JOURNAL, vol. 477, no. 8, JPN6025030543, 29 April 2020 (2020-04-29), pages 1525 - 1539, ISSN: 0005651411 *

Also Published As

Publication number Publication date
BR112022025012A2 (pt) 2023-02-14
CN116075513A (zh) 2023-05-05
US20230203045A1 (en) 2023-06-29
IL298849A (en) 2023-02-01
CO2022019131A2 (es) 2023-03-07
KR20230035311A (ko) 2023-03-13
WO2021252488A1 (en) 2021-12-16
CA3186041A1 (en) 2021-12-16
TW202208368A (zh) 2022-03-01
EP4161933A1 (en) 2023-04-12
AU2021289345A1 (en) 2023-01-19
MX2022015495A (es) 2023-03-14
TWI908811B (zh) 2025-12-21

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